Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Recognizing patterns within the whirling biology of coastal waters

Biological long-term data series are valuable tools when it comes to identifying the human impact on ecosystems or to recognizing climate driven regime shifts. However, in coastal waters, where the freshwater inflow together with weather events and local currents leads to rapidly changing values in salinity, temperature and oxygen, their informative value is limited. The reason is that the marine communities primarily respond to these fast environmental changes, which more or less mask possible responses to any other impact factors. Yet, a group of scientists from Warnemünde has now succeeded in identifying further influences by means of specialized statistical approaches. […]

Sind Epilepsie-Patienten wetterfühlig?

In einer retrospektiven Studie mit über 600 Epilepsiepatienten untersuchten Neurologen des Universitätsklinikums Jena (UKJ), ob die Wahrnehmung von Epilepsie-Patienten, dass das Risiko für epileptische Anfälle mit dem Wetter schwankt, wissenschaftlich belegbar ist. Ihre jetzt in der Fachzeitschrift Epilepsia veröffentlichte Studie konnte tatsächlich ein vergrößertes Anfallsrisiko bei niedrigem Luftdruck und hoher Luftfeuchtigkeit nachweisen – sommerliche Temperaturen dagegen ließen das Risiko sinken. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Die Zerschneidung der Tropenwälder steigert den Ausstoß von Treibhausgasen um weiteres Drittel

In Tropenwäldern steckt etwa die Hälfte des in der gesamten Vegetation der Erde gespeicherten Kohlenstoffs. Entsprechend fatal wirkt sich ihre Abholzung aus. Wissenschaftler schätzen, dass dadurch jedes Jahr 1.000 Millionen Tonnen Kohlenstoff freigesetzt werden, die in Form von Treibhausgasen die globalen Temperaturen erhöhen. Eine neue Studie des UFZ und der University of Maryland zeigt nun, dass die Zerschneidung einst zusammenhängender Waldgebiete die Kohlenstoff-Emissionen um ein weiteres Drittel ansteigen lässt. Dieser bislang vernachlässigte Effekt müsse in den Berichten des Weltklimarates IPCC künftig berücksichtigt werden, betonen die Forscher im Fachjournal Nature Communications. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

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Kontinentalrand mit Leckage

Wenn Methangas vor der Küste Spitzbergens aus dem Meeresboden austritt, ist die Ursache davon nicht immer die Auflösung von Methanhydraten im Zuge einer Temperaturerwärmung. Basis für diese Annahme sind zwei Fahrten zur Küste Spitzbergens. Die Ergebnisse hat Susan Mau hat jetzt gemeinsam mit weiteren Kolleginnen und Kollegen vom MARUM – Zentrum für Marine Umweltwissenschaften der Universität Bremen, dem Alfred-Wegener-Institut Bremerhaven und der Oregon State University (USA) veröffentlicht. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Klimakiller Kuh: Methan-Ausstoß von Vieh könnte bis 2050 um über 70 Prozent steigen

Frankfurt am Main, den 27.03.2017. Kühe gelten als Klimakiller und in Zukunft werden sie sogar einen deutlich höheren Anteil an der Klimaerwärmung haben. Wissenschaftler des Senckenberg, der Royal Botanic Gardens, Kew und des Scotland Rural College, haben herausgefunden, das Futterpflanzen in wärmeren Regionen einen geringeren Nährwert haben. Rinder fressen daher mehr und stoßen mehr Methan aus. Im Zuge des Klimawandels, der damit verbundenen Temperaturerhöhung und weltweit wachsender Tierbestände könnte der Methan-Ausstoss von Vieh demzufolge bis 2050 um über 70 % steigen. Das wiederum würde den Treibhauseffekt verstärken. Die Studie ist soeben im Fachjournal „Biogeosciences“ erschienen. (Mehr in: Pressemitteilungen – idw […]

Camouflage apples

On the long journey from the fruit plantation to the retailer’s shelf, fruits can quickly perish. In particular, the refrigeration inside the cargo containers is not always guaranteed and existing methods for measuring the temperature are not sufficiently reliable. A sensor developed at Empa solves this problem. It looks like a piece of fruit and acts like a piece of fruit – but is actually a spy. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Seltene Proteine kollabieren früher

Einige Organismen halten es in heissen Quellen aus, andere nur bei milden Temperaturen, denn ihre Proteine sind nicht gleichermassen hitzebeständig. Diesen Unterschieden sind ETH-Forschende nachgegangen, und sie zeigten, dass oft nur wenige Schlüsselproteine über Leben und Hitzetod einer Zelle entscheiden. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Mehr wärmeliebende Tiere und Pflanzen durch Klimawandel

Frankfurt, den 20.02.2017. In Deutschland hat seit 1980 der Bestand von wärmeliebenden Arten zugenommen. Die bisher umfassendste Studie zu diesem Thema quer durch alle Ökosysteme belegt, dass dieser Trend besonders ausgeprägt bei wärmeliebenden Arten an Land ist. Am stärksten nahmenlaut der kürzlich im Fachjournal „Nature Ecology and Evolution“ veröffentlichten Studie unter der Leitung von Senckenberg Wissenschaftlerinnen wärmeliebende Vögel, Schmetterlinge, Bodenorganismen und Flechten zu. Die klimawandelbedingte Temperaturerhöhung hat sich anscheinend in den letzten 30 Jahren großflächig auf die Entwicklung des Bestands von Arten ausgewirkt. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Risiko der Zika-Übertragung durch Mücken in Deutschland analysiert

Hamburg. Wissenschaftlerinnen und Wissenschaftler des Bernhard-Nocht-Instituts für Tropenmedizin (BNITM) haben in Zusammenarbeit mit Kolleginnen und Kollegen der Gesellschaft zur Förderung der Stechmückenbekämpfung (GFS) in Speyer in Laborexperimenten bestätigt, dass Exemplare der asiatischen Tigermücke Aedes albopictus, die nach Süddeutschland eingeschleppt wurden, bei Temperaturen von mindestens 27°C das Zika-Virus übertragen können. Demgegenüber scheinen die in Deutschland weit verbreitete gemeine Hausmücke Culex pipiens sowie verwandte Arten wie Culex torrentium nicht zu einer Übertragung fähig zu sein. Die Arbeiten wurden gerade in der Fachzeitschrift Eurosurveillance veröffentlicht. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Temperature drives biodiversity

Why is the diversity of animals and plants so unevenly distributed on our planet? An international research team headed by the University of Würzburg has provided new data on this core issue of ecology. They found biodiversity to be driven by temperature. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Cancer news

Combined molecular biology test is the first to distinguish benign pancreatic lesions

23. Jun. 2017

When performed in tandem, two molecular biology laboratory tests distinguish, with near certainty, pancreatic lesions that mimic early signs of cancer but are completely benign. The lesions almost never progress to cancer, so patients may be spared unnecessary pancreatic cancer screenings or operations. The two-test combination is the only one to date that can accurately and specifically identify these benign pancreatic lesions. (Mehr in: Cancer News — ScienceDaily)

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Existing drugs could benefit patients with bone cancer, genetic study suggests

23. Jun. 2017

A subgroup of patients with osteosarcoma — a form of bone cancer — could be helped by an existing drug, suggest scientists. In the largest genetic sequencing study of osteosarcoma to date, scientists discovered that 10 percent of patients with a genetic mutation in particular growth factor signalling genes may benefit from existing drugs, known as IGF1R inhibitors. (Mehr in: Cancer News — ScienceDaily)

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A unique amino acid for brain cancer therapy

23. Jun. 2017

Photodynamic therapy is often used to treat brain tumors because of its specificity — it can target very small regions containing cancerous cells while sparing the normal cells around it from damage. It works by injecting a drug called a photosensitizer into the bloodstream, where it gathers in cells, and then exposing the drug-filled cells to light. When the photosensitizer is exposed to this light, it emits what is known as a reactive oxygen species (ROS) that causes the cells to die. (Mehr in: Cancer News — ScienceDaily)

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Tiny nanoparticles offer significant potential in detecting, treating disease new review of work on exosomes

22. Jun. 2017

Exosomes – tiny biological nanoparticles which transfer information between cells – offer significant potential in detecting and treating disease, the most comprehensive overview so far of research in the field has concluded. Areas which could benefit include cancer treatment and regenerative medicine. (Mehr in: Cancer News — ScienceDaily)

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A rising star: Researchers dissect the process by which blood vessels shrink, which could have important implications for human health

22. Jun. 2017

It’s a tiny marine invertebrate, no more than 3 millimeters in size. But closely related to humans, Botryllus schlosseri might hold the key to new treatments for cancer and a host of vascular diseases. (Mehr in: Cancer News — ScienceDaily)

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Similarities between next-generation prostate cancer drugs discovered

22. Jun. 2017

For the first time, researchers have shown how a class of advanced prostate cancer drugs are processed in the body and how their anti-tumor activity might change depending on how they are metabolized. Their pre-clinical findings may lay the foundation for improving therapies for treatment-resistant, aggressive prostate cancer. (Mehr in: Cancer News — ScienceDaily)

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Better use of current drugs to target cancer

22. Jun. 2017

Researchers worked backwards, employing a series of drugs used in the clinic to understand a new way that cancer stem cells can be killed. (Mehr in: Cancer News — ScienceDaily)

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An enzyme to synthetize carbohydrates designed

22. Jun. 2017

Sugar or carbohydrate synthesis is important for the development of diagnostic tests, vaccines and new drugs. In a study, researchers have synthesized carbohydrates with enzymes through a reaction that was not much studied so far on these biomolecules and which creates few by-products. (Mehr in: Cancer News — ScienceDaily)

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Flipping the switch to stop tumor development

22. Jun. 2017

Researchers show how a protein prevents the uncontrolled expansion of immune cells, and have outlined their findings in a new report. (Mehr in: Cancer News — ScienceDaily)

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Secondhand smoke exposure among nonsmoking adult cancer survivors has declined

22. Jun. 2017

From 1999/2000 to 2011/2012, exposure to secondhand smoke among nonsmoking adult cancer survivors declined from 39.6 percent to 15.7 percent, but rates of exposure were higher among those with a history of a smoking-related cancer and those living below the federal poverty level compared with those with other types of cancer and those with the highest incomes, respectively. (Mehr in: Cancer News — ScienceDaily)

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First-line immunotherapy treatment can improve survival for subset of lung cancer patients

22. Jun. 2017

Findings from a phase III clinical trial for advanced lung cancer patients could help oncologists better predict which patients are likely to receive the most benefit from immunotherapy as a first-line treatment based on the unique molecular characteristics of their tumor, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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‚Rosetta Stone‘ to decode immune recognition

21. Jun. 2017

Medical researchers have developed an algorithm that predicts T cell recognition of antigens and sets the stage to more effectively harness the immune system. (Mehr in: Cancer News — ScienceDaily)

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Underused cancer test could improve treatment for thousands

21. Jun. 2017

A simple blood test could improve treatment for more than 1 in 6 stage 2 colon cancer patients, suggests new research. The researchers also discovered that many patients who could benefit from the test likely aren’t receiving it. (Mehr in: Cancer News — ScienceDaily)

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New antibody uses 1-2 punch to potentially treat blood cancers

21. Jun. 2017

Researchers have developed a two-pronged approach to blood cancer treatment: 1) attacking cancer cells directly and/or 2) driving them from the nurturing bone marrow environment into the peripheral blood streams, where they are more vulnerable (for example, to chemotherapy). (Mehr in: Cancer News — ScienceDaily)

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New inhibitor drug shows promise in relapsed leukemia

21. Jun. 2017

A new drug shows promise in its ability to target one of the most common and sinister mutations of acute myeloid leukemia (AML), according to researchers. In a first-in-human study, researchers treated relapsed patients with gilteritinib, an FLT3 inhibitor, and found it was a well-tolerated drug that led to frequent and more-sustained-than-expected clinical responses, almost exclusively in patients with this mutation. (Mehr in: Cancer News — ScienceDaily)

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New sensors could enable more affordable detection of pollution, diseases

21. Jun. 2017

When it comes to testing for cancer, environmental pollution and food contaminants, traditional sensors can help. The challenges are that they often are bulky, expensive, non-intuitive and complicated. Now, one team reports that portable pressure-based detectors coupled with smartphone software could provide a simpler, more affordable alternative while still maintaining sensitivity. (Mehr in: Cancer News — ScienceDaily)

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Finding the perfect match: New approach to battle drug-resistant bacteria

20. Jun. 2017

Antibiotics were the wonder drug of the 20th century, but bacteria evolved resistance. According to the CDC, more than 2 million people in the U.S. develop MDR infections every year. Researchers have now developed a rapid screen to pair existing FDA-approved drugs to combat MDR infections. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

Art / Nature:Contemporary Art in Natural History Museums and Collections

02. Jun. 2017

A pilot project in cooperation with the German Federal Cultural Foundation.

The conference outlines recent and ongoing art projects and art programmes in natural history museums and in the natural history collections of multidisciplinary museums. In doing so, it aims to reflect upon and discuss the expectations, potentials, possible limitations and values of these kinds of interactions and interventions from the perspectives of curators, artists and researchers. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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8th Mildred Scheel Cancer Conference

02. Jun. 2017

Zum 8. Mal lädt die Deutsche Krebshilfe, gemeinsam mit der Deutschen Krebsgesellschaft, zur Mildred Scheel Cancer Conference ein. Vom 14.-16. Juni 2017 treffen sich renommierte Krebsexperten in Bonn, um über aktuelle Entwicklungen auf dem Gebiet der onkologischen Forschung zu diskutieren. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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8th International Triticeae Symposium 2017

02. Jun. 2017

This symposium includes four main themes:

Taxonomy, Phylogeny and Phytogeography Biodiversity and Conservation Genetics and Genomics Breeding and Utilization (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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8. Bayerischer Fachkongress Glücksspiel

02. Jun. 2017

Am 28. Juni 2017 findet der 8. Bayerische Fachkongress Glücksspiel im Novotel München City statt. Der Kongress läuft dieses Jahr unter dem Motto Migration – Trauma – Glücksspiel (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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7. HIPS Symposium on pharmaceutical sciences devoted to infection research

02. Jun. 2017

The HIPS symposium brings together renowed scientists and young investigators from three pharmaceutical communities: natural products, medicinal chemistry and drug delivery. It provides a forum for scientists to exchange ideas while crossing boundaries of classical disciplines. At the same time it gives young investigators the opportunity to obtain valuable feedback on their projects by international experts in the respective fields. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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3. Zukunftskongress "Technik zum Menschen bringen"

02. Jun. 2017

Der 3. Zukunftskongress „Technik zum Menschen bringen“ des Bundesministeriums für Bildung und Forschung findet vom 26. bis 27. Juni in Bonn (World Conference Center Bonn) statt. Diskutieren Sie mit uns gemeinsam neue Trends und informieren Sie sich über laufende und künftige Fördermaßnahmen des BMBF. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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37. Jahestagung Deutsche Gesellschaft für Senologie e.V.

02. Jun. 2017

Zur diesjährigen Jahrestagung der Deutschen Gesellschaft für Senologie e. V. (DGS) vom 29. Juni bis 1. Juli 2017 im CityCube Berlin werden wieder über 2500 Experten für Brusterkrankungen erwartet. Alle Experteninnen und Experten der verschiedenen Fachdisziplinen, die die Senologie vereint diskutieren auf den ca. 170 wissenschaftlichen Sitzungen, Kursen und Debatten gemeinsam über aktuelle Fragestellungen zur Früherkennung, Diagnostik, Therapie und Nachsorge von Brusterkrankungen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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