Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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The future of crop engineering

Photosynthesis is the process underlying all plant growth. Scientists aim to boost photosynthesis to meet the increasing global demand for food by engineering its key enzyme Rubisco. Now, researchers at the Max Planck Institute of Biochemistry have succeeded in producing functional plant Rubisco in a bacterium. This allows genetic engineering of the enzyme. The study could one day lead to better crop yields and plant varieties with increased water-use efficiencies or enhanced temperature resistance. The results were published in Science. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Earth-air heat exchanger best way to protect animals in livestock buildings against climate change

Without countermeasures, climate change will negatively impact animals in pig and poultry production. Beside the health and wellbeing of the animals, heat stress also affects performance and, as a result, profitability. As the animals are predominantly kept in confined livestock buildings equipped with mechanical ventilation systems, researchers at Vetmeduni Vienna examined the inlet air temperature of several air cooling systems. The best solution, they found, is the use of the earth for heat storage via an earth-air heat exchanger (EAHE). An EAHE cools in the summer, and warms up the inlet air during wintertime. Published in Biosystems Engineering. (Mehr in: […]

Klimawandel begünstigt Methanfreisetzung aus Gewässern

Es ist ein Teufelskreis: Infolge des Klimawandels und steigender Temperaturen tritt immer mehr Methan aus Binnengewässern auf der ganzen Welt aus. Die Freisetzung des Treibhausgases Methan wiederum führt zu einem weiteren Temperaturanstieg und einer Beschleunigung des Klimawandels. WissenschaftlerInnen vom Leibniz-Institut für Gewässerökologie und Binnenfischerei (IGB) waren an einer niederländischen Studie beteiligt, die einen deutlichen Zusammenhang zwischen Temperaturanstieg und Methanemissionen aus Gewässern zeigt. Ein Temperaturanstieg von nur einem Grad Celsius steigert die Methanfreisetzung um sechs bis 20 Prozent. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Abkühlung im hohen Norden führte zu Wüstenbildung in Nordafrika

Das Ende der „Grünen Sahara“: Fallende Temperaturen in hohen nördlichen Breiten führten dazu, dass vor 5500 Jahren die Niederschläge in Nordafrika deutlich zurückgingen. Das zeigen Analysen von Blattwachsen im Sediment des Golfs von Guinea. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Deforestation linked to palm oil production is making Indonesia warmer

In the past decades, large areas of forest in Sumatra, Indonesia have been replaced by cash crops like oil palm and rubber plantations. New research, published in the European Geosciences Union journal Biogeosciences, shows that these changes in land use increase temperatures in the region. The added warming could affect plants and animals and make parts of the country more vulnerable to wildfires. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

New self-regulating nanoparticles could treat cancer

Scientists have developed ‚intelligent‘ nanoparticles which heat up to a temperature high enough to kill cancerous cells — but which then self-regulate and lose heat before they get hot enough to harm healthy tissue. (Mehr in: Cancer News — ScienceDaily)

Getreide, das der Dürre trotzt

Ein internationales Konsortium unter der Leitung des „International Crops Research Institute for the Semi-Arid Tropics“ hat unter Beteiligung eines Forschungsteams um den Systembiologen Wolfram Weckwerth von der Universität Wien das Genom der trockenresistenten Getreidepflanze Pennisetum glaucum (Perlhirse) sequenziert. Die Pflanze hat große Bedeutung für die Landwirtschaft in trockenen Regionen in Afrika und Asien. Perlhirse ist in der Lage, trotz großer Trockenheit und hohen Temperaturen bis zu 42°C Erträge zu liefern, im Gegensatz zu Weizen, Reis und Mais. Die Studie wird aktuell in „Nature Biotechnology“ veröffentlicht. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Klimaerwärmung ist schuld am Rückgang der Braunbären in Europa

Frankfurt am Main, den 7. September 2017. Die Klimaerwärmung ist verantwortlich dafür, dass der Bestand der Braunbären in Europa seit dem Ende der letzten Eiszeit dramatisch geschrumpft ist. Steigende Wintertemperaturen während der letzten 12.000 Jahre haben die Fortpflanzungsrate der Braunbären verringert und zu deren Verschwinden beigetragen, berichtet eine internationale Forschergruppe, darunter ein Senckenberg-Wissenschaftler, im Fachblatt „Scientific Reports“. Die Klimaerwärmung hat dem Braunbären zudem indirekt geschadet: größere Flächen wurden für den Ackerbau nutzbar, was den Lebensraum der Tiere zusätzlich verkleinerte. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Recognizing patterns within the whirling biology of coastal waters

Biological long-term data series are valuable tools when it comes to identifying the human impact on ecosystems or to recognizing climate driven regime shifts. However, in coastal waters, where the freshwater inflow together with weather events and local currents leads to rapidly changing values in salinity, temperature and oxygen, their informative value is limited. The reason is that the marine communities primarily respond to these fast environmental changes, which more or less mask possible responses to any other impact factors. Yet, a group of scientists from Warnemünde has now succeeded in identifying further influences by means of specialized statistical approaches. […]

Sind Epilepsie-Patienten wetterfühlig?

In einer retrospektiven Studie mit über 600 Epilepsiepatienten untersuchten Neurologen des Universitätsklinikums Jena (UKJ), ob die Wahrnehmung von Epilepsie-Patienten, dass das Risiko für epileptische Anfälle mit dem Wetter schwankt, wissenschaftlich belegbar ist. Ihre jetzt in der Fachzeitschrift Epilepsia veröffentlichte Studie konnte tatsächlich ein vergrößertes Anfallsrisiko bei niedrigem Luftdruck und hoher Luftfeuchtigkeit nachweisen – sommerliche Temperaturen dagegen ließen das Risiko sinken. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Cancer news

What does hair loss have to teach us about cancer metastasis?

15. Dez. 2017

Researchers have identified a signaling pathway regulating cell migration and metastasis. Unexpected hair loss in a preclinical model helped them to identify the pathway. When cells within the skin that maintain hair follicles migrate too often, hair follicle maintenance is disrupted. Researchers speculated that this pathway might also play a role in cancer cell migration. Indeed, they showed that disrupting this pathway in preclinical models increased metastasis. (Mehr in: Cancer News — ScienceDaily)

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Cancer immunotherapy may work better in patients with specific genes

15. Dez. 2017

Investigators have been trying to understand why and have recently found how an individual’s own genes can play a role in the response to the immunotherapy drugs. (Mehr in: Cancer News — ScienceDaily)

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Mechanism identified of impaired dendritic cell function that weakens response to cancer

14. Dez. 2017

The mechanism implicated in the defective function of tumor-associated dendritic cells (DCs), a specialized type of immune cells that expose the antigens on their surface to activate the T cells, has now been revealed by researchers. (Mehr in: Cancer News — ScienceDaily)

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Bioengineers imagine the future of vaccines and immunotherapy

14. Dez. 2017

In the not-too-distant future, nanoparticles delivered to a cancer patient’s immune cells might teach the cells to destroy tumors. A flu vaccine might look and feel like applying a small, round bandage to your skin. These are examples of how innovative biomaterials could enhance vaccines against HIV and other infectious diseases and immunotherapies for patients with cancer or dampen responses in autoimmune disorders, allergies and transplanted organ recipients. (Mehr in: Cancer News — ScienceDaily)

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How defeating THOR could bring a hammer down on cancer

14. Dez. 2017

Researchers have uncovered a novel gene they named THOR. It’s a highly conserved long non-coding RNA that plays a role in cancer development. Knocking it out can halt the growth of tumors. (Mehr in: Cancer News — ScienceDaily)

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‚Bet hedging‘ explains the efficacy of many combination cancer therapies

14. Dez. 2017

The efficacy of many FDA-approved cancer drug combinations is not due to synergistic interactions between drugs, but rather to a form of „bet hedging,“ according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Liquid biopsy results differed substantially between 2 providers

14. Dez. 2017

Two prostate cancer researchers found significant disparities when they submitted identical patient samples to two different commercial liquid biopsy providers. Liquid biopsy is a new and noninvasive alternative to tumor tissue sequencing, and it is intended to specifically detect and sequence tumor DNA circulating in patients‘ blood. The results are used to help guide doctors to tailor the best treatment for patients at each point of their disease. (Mehr in: Cancer News — ScienceDaily)

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Deadly heart rhythm halted by noninvasive radiation therapy

14. Dez. 2017

Radiation therapy often is used to treat cancer patients. Now, doctors have shown that radiation therapy — aimed directly at the heart — can be used to treat patients with a life-threatening heart rhythm. They treated five patients with irregular heart rhythms, called ventricular tachycardia, who had not responded to standard treatments. The therapy resulted in a dramatic reduction in the number of ventricular tachycardia episodes. (Mehr in: Cancer News — ScienceDaily)

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CT scans of Egyptian mummies reveal oldest known cases of breast cancer and multiple myeloma

14. Dez. 2017

An international team has discovered the world’s oldest known cases of breast cancer and multiple myeloma (a type of bone marrow cancer). The discoveries were made by conducting CT scans of two mummies found in the pharaonic necropolis of Qubbet el-Hawa in Aswan, Egypt. (Mehr in: Cancer News — ScienceDaily)

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Frequent sun exposure may cue gene fusion found in skin cancer

14. Dez. 2017

Researchers have determined that a particular fusion gene has a tendency to be found in cutaneous squamous cell carcinoma (cSCC) lesions on skin exposed frequently to the sun. The fusion gene is unique to cSCC and appears to be related to frequent sun exposure. It is believed that the work will open doors to a new form of personalized cSCC treatment. (Mehr in: Cancer News — ScienceDaily)

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What keeps stem cells in their undifferentiated state?

13. Dez. 2017

A special cluster of proteins helps unwind DNA during cell division and plays a key role in keeping stem cells in their immature state, scientists have discovered. This study also points to a better understanding of how cancer cells manage to sustain rapid cell division without triggering cell death. (Mehr in: Cancer News — ScienceDaily)

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A metallopeptide targets and disrupts mitochondrial function in breast cancer stem cells

13. Dez. 2017

Killing malignant mitochondria is one of the most promising approaches in the development of new anticancer drugs. Scientists have now synthesized a copper-containing peptide that is readily taken up by mitochondria in breast cancer stem cells, where it effectively induces apoptosis. The study also highlights the powerful therapeutic potential of the metallopeptides. (Mehr in: Cancer News — ScienceDaily)

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Male virgins can still acquire HPV, study finds

13. Dez. 2017

Men who have never engaged in sexual intercourse are still at risk for acquiring HPV, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Scientists develop new artificial ovary prototype

13. Dez. 2017

Researchers have taken important steps towards creating transplantable artificial ovaries. Once successful, these could be of value to women struggling with infertility or cancer patients who cannot conceive after undergoing radiation or chemotherapy. The research team has identified a protein formulation that closely resembles the structure and rigidity of the natural tissue lining a woman’s ovaries. (Mehr in: Cancer News — ScienceDaily)

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Important new aspects are revealed about the control of cell division

12. Dez. 2017

Experts have published a new study on the mechanisms that regulate cell division and guarantee the correct distribution of chromosomes during this process. In particular, they especially highlight the fundamental role that an organelle, specifically the nucleolus, plays in the coordination of these processes. (Mehr in: Cancer News — ScienceDaily)

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Closing in on advanced prostate cancer

12. Dez. 2017

Medical researchers have discovered a new avenue through which to attack prostrate cancer cells that have developed drug-resistance. (Mehr in: Cancer News — ScienceDaily)

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Simple test can diagnose two cancer types

12. Dez. 2017

A blood test using infrared spectroscopy can be used to diagnose two types of cancer, lymphoma and melanoma, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

12. Jahrestagung der Deutschen Wirbelsäulengesellschaft (DWG)

20. Nov. 2017

Der diesjährige Schwerpunkt des Kongresses liegt auf den Themen Trauma und Tumor in der Wirbelsäulenchirurgie. Wichtige wissenschaftliche Beiträge zu Tumorerkrankungen, degenerativen Erkrankungen, entzündlichen und metabolischen Erkrankungen, Verletzungen und Deformitäten aber auch zu innovativen Techniken erwarten die Besucherinnen und Besucher. Dabei steht ein fächerübergreifender Ansatz im Vordergrund, denn auch auf dem Gebiet der Wirbelsäulenheilkunde gilt es, Bewährtes zu erhalten und gleichzeitig neuen Behandlungsmethoden gegenüber offen zu sein. Dass die Deutsche Wirbelsäulengesellschaft diesen Anspruch ernst nimmt, zeigt auch die Zentren-Zertifizierung, die in diesem Jahr gestartet wurde. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Akademievorlesung "Gentechnologien damals, heute und morgen" | 02.11.2017 18:00 Uhr – 21:00 Uhr

01. Nov. 2017

Mit der Akademievorlesung zieht die Interdisziplinare Arbeitsgruppe „Gentechnologiebericht“ 16 Jahre nach ihrer Gründung Bilanz anlässlich eines heute wie damals höchst umstrittenen und viel diskutierten Forschungsbereichs. In Expertenbeiträgen und Podiumsdiskussionen werden die Gentechnologien dabei sowohl in ihrer historischen und zukünftigen Entwicklung als auch in ihrer aktuellen gesellschafts- und forschungspolitischen Relevanz eingeordnet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Air Pollution and Health: New Research Perspectives for a Growing Global Crisis

01. Nov. 2017

Joint symposium by the Academy of Science of South Africa and the Leopoldina (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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6. Morbi-RSA Symposium

01. Nov. 2017

Eigentlich soll der morbiditätsorientierte Risikostrukturausgleich – kurz: Morbi-RSA – den Finanzausgleich zwischen den gesetzlichen Krankenversicherungen regeln. Fakt ist: Die Kassen haben nach wie vor die Möglichkeit, ärztliche Diagnosen zu beeinflussen, um so höhere Zuwendungen aus dem Gesundheitsfonds zu erreichen. Das geht aus einem Gutachten des Berliner IGES Instituts hervor – und liefert jede Menge Zündstoff für das 6. Morbi-RSA Symposium am 20. November 2017 in Essen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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20. Gesundheitspolitisches Kolloquium

01. Nov. 2017

Wer übernimmt die Verantwortung in der Notfallversorgung? 20. Gesundheitspolitisches Kolloquium an der Frankfurt UAS diskutiert Optionen der Notfallversorgung in Hessen (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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20. Deutsche Mukoviszidose Tagung

01. Nov. 2017

Biomarker im klinischen Alltag, Problemkeime jenseits des Pseudomonas, die Bedeutung von Physiotherapie in der Mukoviszidose-Behandlung – dies sind nur einige Beispiele für das breite Themenspektrum der Deutschen Mukoviszidose Tagung, die vom 16. bis 18. November 2017 in Würzburg stattfindet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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13. Kolloquium Prozessanalytik: Prozessführung in der modernen Produktion

01. Nov. 2017

Was kann die Prozessindustrie im Hinblick auf die „Industrie 4.0“ von der Fertigungstechnik lernen? Mit dieser Frage schlägt das 13. Kolloquium „Prozessanalytik“ die Brücke zwischen zwei technologischen Bereichen, die für die chemisch/pharmazeutische Prozessindustrie aktueller denn je sind. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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