Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Recognizing patterns within the whirling biology of coastal waters

Biological long-term data series are valuable tools when it comes to identifying the human impact on ecosystems or to recognizing climate driven regime shifts. However, in coastal waters, where the freshwater inflow together with weather events and local currents leads to rapidly changing values in salinity, temperature and oxygen, their informative value is limited. The reason is that the marine communities primarily respond to these fast environmental changes, which more or less mask possible responses to any other impact factors. Yet, a group of scientists from Warnemünde has now succeeded in identifying further influences by means of specialized statistical approaches. […]

Sind Epilepsie-Patienten wetterfühlig?

In einer retrospektiven Studie mit über 600 Epilepsiepatienten untersuchten Neurologen des Universitätsklinikums Jena (UKJ), ob die Wahrnehmung von Epilepsie-Patienten, dass das Risiko für epileptische Anfälle mit dem Wetter schwankt, wissenschaftlich belegbar ist. Ihre jetzt in der Fachzeitschrift Epilepsia veröffentlichte Studie konnte tatsächlich ein vergrößertes Anfallsrisiko bei niedrigem Luftdruck und hoher Luftfeuchtigkeit nachweisen – sommerliche Temperaturen dagegen ließen das Risiko sinken. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Die Zerschneidung der Tropenwälder steigert den Ausstoß von Treibhausgasen um weiteres Drittel

In Tropenwäldern steckt etwa die Hälfte des in der gesamten Vegetation der Erde gespeicherten Kohlenstoffs. Entsprechend fatal wirkt sich ihre Abholzung aus. Wissenschaftler schätzen, dass dadurch jedes Jahr 1.000 Millionen Tonnen Kohlenstoff freigesetzt werden, die in Form von Treibhausgasen die globalen Temperaturen erhöhen. Eine neue Studie des UFZ und der University of Maryland zeigt nun, dass die Zerschneidung einst zusammenhängender Waldgebiete die Kohlenstoff-Emissionen um ein weiteres Drittel ansteigen lässt. Dieser bislang vernachlässigte Effekt müsse in den Berichten des Weltklimarates IPCC künftig berücksichtigt werden, betonen die Forscher im Fachjournal Nature Communications. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

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Kontinentalrand mit Leckage

Wenn Methangas vor der Küste Spitzbergens aus dem Meeresboden austritt, ist die Ursache davon nicht immer die Auflösung von Methanhydraten im Zuge einer Temperaturerwärmung. Basis für diese Annahme sind zwei Fahrten zur Küste Spitzbergens. Die Ergebnisse hat Susan Mau hat jetzt gemeinsam mit weiteren Kolleginnen und Kollegen vom MARUM – Zentrum für Marine Umweltwissenschaften der Universität Bremen, dem Alfred-Wegener-Institut Bremerhaven und der Oregon State University (USA) veröffentlicht. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Klimakiller Kuh: Methan-Ausstoß von Vieh könnte bis 2050 um über 70 Prozent steigen

Frankfurt am Main, den 27.03.2017. Kühe gelten als Klimakiller und in Zukunft werden sie sogar einen deutlich höheren Anteil an der Klimaerwärmung haben. Wissenschaftler des Senckenberg, der Royal Botanic Gardens, Kew und des Scotland Rural College, haben herausgefunden, das Futterpflanzen in wärmeren Regionen einen geringeren Nährwert haben. Rinder fressen daher mehr und stoßen mehr Methan aus. Im Zuge des Klimawandels, der damit verbundenen Temperaturerhöhung und weltweit wachsender Tierbestände könnte der Methan-Ausstoss von Vieh demzufolge bis 2050 um über 70 % steigen. Das wiederum würde den Treibhauseffekt verstärken. Die Studie ist soeben im Fachjournal „Biogeosciences“ erschienen. (Mehr in: Pressemitteilungen – idw […]

Camouflage apples

On the long journey from the fruit plantation to the retailer’s shelf, fruits can quickly perish. In particular, the refrigeration inside the cargo containers is not always guaranteed and existing methods for measuring the temperature are not sufficiently reliable. A sensor developed at Empa solves this problem. It looks like a piece of fruit and acts like a piece of fruit – but is actually a spy. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Seltene Proteine kollabieren früher

Einige Organismen halten es in heissen Quellen aus, andere nur bei milden Temperaturen, denn ihre Proteine sind nicht gleichermassen hitzebeständig. Diesen Unterschieden sind ETH-Forschende nachgegangen, und sie zeigten, dass oft nur wenige Schlüsselproteine über Leben und Hitzetod einer Zelle entscheiden. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Mehr wärmeliebende Tiere und Pflanzen durch Klimawandel

Frankfurt, den 20.02.2017. In Deutschland hat seit 1980 der Bestand von wärmeliebenden Arten zugenommen. Die bisher umfassendste Studie zu diesem Thema quer durch alle Ökosysteme belegt, dass dieser Trend besonders ausgeprägt bei wärmeliebenden Arten an Land ist. Am stärksten nahmenlaut der kürzlich im Fachjournal „Nature Ecology and Evolution“ veröffentlichten Studie unter der Leitung von Senckenberg Wissenschaftlerinnen wärmeliebende Vögel, Schmetterlinge, Bodenorganismen und Flechten zu. Die klimawandelbedingte Temperaturerhöhung hat sich anscheinend in den letzten 30 Jahren großflächig auf die Entwicklung des Bestands von Arten ausgewirkt. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Risiko der Zika-Übertragung durch Mücken in Deutschland analysiert

Hamburg. Wissenschaftlerinnen und Wissenschaftler des Bernhard-Nocht-Instituts für Tropenmedizin (BNITM) haben in Zusammenarbeit mit Kolleginnen und Kollegen der Gesellschaft zur Förderung der Stechmückenbekämpfung (GFS) in Speyer in Laborexperimenten bestätigt, dass Exemplare der asiatischen Tigermücke Aedes albopictus, die nach Süddeutschland eingeschleppt wurden, bei Temperaturen von mindestens 27°C das Zika-Virus übertragen können. Demgegenüber scheinen die in Deutschland weit verbreitete gemeine Hausmücke Culex pipiens sowie verwandte Arten wie Culex torrentium nicht zu einer Übertragung fähig zu sein. Die Arbeiten wurden gerade in der Fachzeitschrift Eurosurveillance veröffentlicht. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Temperature drives biodiversity

Why is the diversity of animals and plants so unevenly distributed on our planet? An international research team headed by the University of Würzburg has provided new data on this core issue of ecology. They found biodiversity to be driven by temperature. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Cancer news

Study of California kidney cancer shows declining incidence, end of a trend

18. Aug. 2017

A study of kidney cancer incidence in California over 25 years is the first report to demonstrate that the rising rate of kidney cancer seen in the US over the past two decades may have ended. (Mehr in: Cancer News — ScienceDaily)

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Histone 1, the guardian of genome stability

18. Aug. 2017

Genomic instability is the main risk factor for tumor development in humans. Therefore understanding its origin and and exploring therapeutic targets is paramount. Histone 1 silences a region of the genome that causes irreparable DNA damage when translated and is lethal for the organism. (Mehr in: Cancer News — ScienceDaily)

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A better way to measure mortality trends?

17. Aug. 2017

A new study suggests long-term mortality trends may be better understood by focusing on life-years lost — remaining life expectancy for a decedent — instead of solely looking at cause of death. (Mehr in: Cancer News — ScienceDaily)

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Gold nanostars and immunotherapy vaccinate mice against cancer

17. Aug. 2017

By combining an FDA-approved cancer immunotherapy with an emerging tumor-roasting nanotechnology, researchers improved the efficacy of both therapies in a proof-of-concept study using mice. The potent combination also attacked satellite tumors and distant cancerous cells, completely curing two mice and effectively vaccinating one against the disease. (Mehr in: Cancer News — ScienceDaily)

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New terahertz imaging approach could speed up skin cancer detection

17. Aug. 2017

Researchers have developed a new terahertz imaging approach that, for the first time, can acquire micron-scale resolution images while retaining computational approaches designed to speed up image acquisition. (Mehr in: Cancer News — ScienceDaily)

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New Pathology Atlas maps genes in cancer to accelerate progress in personalized medicine

17. Aug. 2017

A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns of individual cancers observed in the study strongly reinforces the need for personalized cancer treatment based on precision medicine. (Mehr in: Cancer News — ScienceDaily)

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Scientists develop novel immunotherapy technology for prostate cancer

17. Aug. 2017

A novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer-specific protein has been described in a new article. (Mehr in: Cancer News — ScienceDaily)

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Are stem cells the link between bacteria and cancer?

17. Aug. 2017

A new mechanism of stomach gland regeneration reveals impact of Helicobacter pylori infection. (Mehr in: Cancer News — ScienceDaily)

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Energy dense foods may increase cancer risk regardless of obesity status

17. Aug. 2017

While there is a proven link between obesity and certain types of cancer, less is known about how the ratio of energy to food weight, otherwise known as dietary energy density (DED), contributes to cancer risk. To find out, researchers looked at DED in the diets of post-menopausal women and discovered that consuming high DED foods was tied to a 10 percent increase in obesity-related cancer among normal weight women. (Mehr in: Cancer News — ScienceDaily)

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New strategy to treat aggressive lung cancer

16. Aug. 2017

Research on a novel therapeutic avenue for an aggressive and difficult to treat subgroup of lung cancer has now been shared in a new article. (Mehr in: Cancer News — ScienceDaily)

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Problems with DNA replication can cause epigenetic changes that may be inherited for several generations

16. Aug. 2017

Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to five generations. They also identified the cause of these epigenetic changes, which is related to the loss of a molecular mechanism in charge of silencing genes. Their results will change the way we think about the impact of replication stress in cancer and during embryonic development, as well as its inter-generational inheritance. (Mehr in: Cancer News — ScienceDaily)

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Popular immunotherapy target turns out to have a surprising buddy

16. Aug. 2017

The majority of current cancer immunotherapies focus on PD-L1. This well-studied protein turns out to be controlled by a partner, CMTM6, a previously unexplored molecule that is now suddenly also a potential therapeutic target. (Mehr in: Cancer News — ScienceDaily)

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Toxic formaldehyde is produced inside our own cells, scientists discover

16. Aug. 2017

New research has revealed that some of the toxin formaldehyde in our bodies does not come from our environment — it is a by-product of an essential reaction inside our own cells. This could provide new targets for developing cancer therapies. (Mehr in: Cancer News — ScienceDaily)

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Multicolor MRIs could aid disease detection

16. Aug. 2017

Researchers have developed a method that could make magnetic resonance imaging — MRI — multicolor. Current MRI techniques rely on a single contrast agent injected into a patient’s veins to vivify images. The new method uses two at once, which could allow doctors to map multiple characteristics of a patient’s internal organs in a single MRI. The strategy could serve as a research tool and even aid disease diagnosis. (Mehr in: Cancer News — ScienceDaily)

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Estrogen receptor stem cells found in mammary glands

16. Aug. 2017

One of the key questions in stem cell and cancer biology is to understand the cellular hierarchy governing tissue development and maintenance and the cancer cell of origin. Researchers have now identified a novel lineage – restricted stem cell in the mammary gland. In the future, this model will be used to assess whether the clinical heterogeneity observed in breast cancers arises from their different cancer cell of origin. (Mehr in: Cancer News — ScienceDaily)

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Combination of traditional chemotherapy, new drug kills rare cancer cells in mice

16. Aug. 2017

An experimental drug combined with the traditional chemotherapy drug cisplatin, when used in mice, destroyed a rare form of salivary gland tumor and prevented a recurrence within 300 days, a study found. (Mehr in: Cancer News — ScienceDaily)

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How decision-making habits influence the breast cancer treatments women consider

15. Aug. 2017

A new study finds that more than half of women with early stage breast cancer considered an aggressive type of surgery to remove both breasts. The way women generally approach big decisions, combined with their values, impacts what breast cancer treatment they consider, the study also found. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

25. Wiss. Symposium für Psychotherapie: Veränderbarkeit – Ändern/Verändern/Anders am 13./14.10.2017

12. Aug. 2017

1992 wurde das Wissenschaftliche Symposium für Psychotherapie eingeführt. 25 Jahre später lädt die LWL-Universitätsklinik Bochum für Psychosomatische Medizin und Psychotherapie zu einem Jubiläumssymposium ein. Was hat sich verändert und welche Entwicklungen sind zu erwarten? Psychotherapie will ändern und stellt sich der Frage nach der Veränderbarkeit eines Menschen. Die Vorträge reichen von (epi)genetischen über soziologische, kulturelle bis hin zu psychotherapeutischen Themen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Bavarian Summer School 2017 – The Future of Health Care

24. Jul. 2017

From 24/07/ until 04/08/17 the first summer school organized by Study & Work International, an initiative of the Bavarian Association of Universities of Applied Sciences (UAS), takes place at the Lutheran UAS Nuremberg and the technical UAS OTH Amberg-Weiden.The Future of Health Care: New Concepts – New Technologies is the topic of this two-week interdisciplinary summer school for Bachelor’s students from the fields of health care as well as various engineering disciplines (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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15th EUROPEAN CONFERENCE ON ORGANIZED FILMS

08. Jul. 2017

The 15th European Conference on Organized Films (ECOF 15) adds to a successful series of conferences addressing latest findings and advances in the field of thin and ultrathin organic films as well as nanoscience and -technologies. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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14th Dortmund MST Conference – Individualized Healthcare Solutions

05. Jul. 2017

Embracing „Individualized Healthcare Solutions“, the 14th Dortmund MST Conference on July 5, 2017 will present microsystems, production processes and digital technologies for use in medical technology and healthcare. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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14. Dortmunder MST-Konferenz – Individualisierte Gesundheitslösungen

05. Jul. 2017

Unter dem Motto „Individualisierte Gesundheitslösungen“ präsentiert die 14. Dortmunder MST-Konferenz am 5. Juli 2017 Mikrosysteme, mikrotechnische Fertigungsverfahren und digitale Technologien für den Einsatz in der Medizintechnik und Gesundheitsversorgung. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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8. Bayerischer Fachkongress Glücksspiel

02. Jun. 2017

Am 28. Juni 2017 findet der 8. Bayerische Fachkongress Glücksspiel im Novotel München City statt. Der Kongress läuft dieses Jahr unter dem Motto Migration – Trauma – Glücksspiel (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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7. HIPS Symposium on pharmaceutical sciences devoted to infection research

02. Jun. 2017

The HIPS symposium brings together renowed scientists and young investigators from three pharmaceutical communities: natural products, medicinal chemistry and drug delivery. It provides a forum for scientists to exchange ideas while crossing boundaries of classical disciplines. At the same time it gives young investigators the opportunity to obtain valuable feedback on their projects by international experts in the respective fields. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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