A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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From Synapses to Circuits in Health and Disease

6. Inter-Academy Symposium (IAS) der Leopoldina und der Israel Academy of Sciences and Humanities (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

Die optische Vermessung der synaptischen Nano-Welt

Durchbruch bei der Erforschung der Signalwege: Göttinger Wissenschaftler entwi-ckeln höchstauflösende Messungen der Kalziumkonzentration und entschlüsseln die Zahl und Funktion von Kalziumkanälen an der Synapse. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Forscherteam am IST Austria definiert Funktion eines rätselhaften Synapsen-Proteins

Synaptotagmin 7 stellt Effizienz der inhibitorischen Signalübertragung sicher – Studie erschien in Cell Reports (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Störung an den Synapsen

Für Motoneuron-Erkrankungen beschreibt ein Würzburger Forschungsteam einen bislang unbekannten Krankheitsmechanismus. Das sollte bei der Entwicklung von Medikamenten zu einem Umdenken führen. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Wichtiges Molekül für Botenstoffausschüttung in Synapsen identifiziert

Der Freisetzungsort ist entscheidend Damit Nervenzellen miteinander kommunizieren können, werden an ihren Kontaktstellen, den Synapsen, chemische Botenstoffe freigesetzt. Dies geschieht durch synaptische Vesikel (Bläschen), die dabei mit der Zellmembran verschmelzen. Dieser Vorgang findet nicht irgendwo statt, sondern an ganz bestimmten Stellen innerhalb der Synapse. Wissenschaftler vom Leibniz-Forschungsinstitut für Molekulare Pharmakologie und der Freien Universität Berlin haben nun das Molekül identifiziert, das diese Freisetzungsorte definiert und damit ein großes Rätsel in den Neurowissenschaften gelöst. Jetzt ist die wegweisende Arbeit im renommierten Fachmagazin „Neuron“ erschienen. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Synapse für Synapse: Gehirnstruktur des Lernens vollständig kartiert

Einem internationalen Konsortium von Wissenschaftlern unter Beteiligung von Forschern des Leibniz-Instituts für Neurobiologie (LIN) ist es gelungen, jede einzelne Verbindung aller Nervenzellen im Gedächtnissystem der Fliegenlarve komplett zu kartographieren. Diese sogenannten Pilzkörper stellen einen Minimal-Schaltkreis für Lern- und Gedächtnisprozesse dar. Die Ergebnisse wurden im renommierten Fachmagazin Nature publiziert. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Neurobiologie – Der Lieferservice des Lernens

Lernen erfordert einen stetigen Umbau von Nervenzellen. Damit das Material dafür gezielt dorthin gelangt, hat das Gehirn eine ganze Reihe von Steuerungsmechanismen. So beeinflusst die Aktivität der Synapse selbst deren Umbau. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Synapses in the Brain Mirror the Structure of the Visual World

The research team of Prof. Sonja Hofer at the Biozentrum, University of Basel, has discovered why our brain might be so good at perceiving edges and contours. Neurons that respond to different parts of elongated edges are connected and thus exchange information. This can make it easier for the brain to identify contours of objects. The results of the study are now published in the journal “Nature”. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Überaktive Fresszellen könnten geistigen Verfall bei Alzheimer bewirken

Forschende der Universität Zürich zeigen erstmals eine überraschende Wirkung von Fresszellen im Gehirn: Fehlt ihnen das Protein TDP-43, entfernen sie nicht nur die Alzheimer Plaques, sondern auch Synapsen. Vermutlich führt diese Synapsen-Entfernung zum Abbau von Nervenzellen bei Alzheimer und anderen neurodegenerativen Krankheiten. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Overactive Scavenger Cells May Cause Neurodegeneration in Alzheimer’s

For the first time, researchers at the University of Zurich have demonstrated a surprising effect of microglia, the scavenger cells of the brain: If these cells lack the TDP-43 protein, they not only remove Alzheimer’s plaques, but also synapses. This removal of synapses by these cells presumably lead to neurodegeneration observed in Alzheimer’s and other neurodegenerative diseases. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Cancer news

Insight into development of lung cancer

18. Aug. 2018

Lung cancer results from effects of smoking along with multiple genetic components. A new study identifies two main pathways for the role of chromosome 15q25.1 — a leader in increasing susceptibility to lung cancer — in modifying disease risk. One pathway is implicated in nicotine dependence. The other plays a part in biological processes such as nutrient transfer and immune system function. The findings increase our understanding of lung cancer cause and development. (Mehr in: Cancer News — ScienceDaily)

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Like shark attacks and the lottery, unconscious bias influences cancer screening

17. Aug. 2018

Study shows that doctors with personal experience of cancer are more likely to act against established guidelines to recommend that low-risk women receive ovarian cancer screening. (Mehr in: Cancer News — ScienceDaily)

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Exploring the relationship between fever and cancer incidence

17. Aug. 2018

In a new paper, researchers propose a mechanistic hypothesis that focuses on the potential impact infectious fever has on a particular subset of T cells, known as gamma/delta T cells. (Mehr in: Cancer News — ScienceDaily)

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New CRISPR technique skips over portions of genes that can cause disease

16. Aug. 2018

In a new study in cells, researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. Such targeted editing could one day be useful for treating genetic diseases caused by mutations in the genome, such as Duchenne’s muscular dystrophy, Huntington’s disease or some cancers. (Mehr in: Cancer News — ScienceDaily)

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Diagnosing cancer with malaria protein: New method discovered

16. Aug. 2018

Researchers have discovered a method of diagnosing a broad range of cancers at their early stages by utilizing a particular malaria protein, which sticks to cancer cells in blood samples. The researchers hope that this method can be used in cancer screenings in the near future. (Mehr in: Cancer News — ScienceDaily)

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Retinoic acid may improve immune response against melanoma

16. Aug. 2018

Clinical trial results describe a promising strategy to remove one of melanoma’s most powerful defenses: By adding retinoic acid to standard-of-care treatment, researchers were able to turn off myeloid-derived suppressor cells (MDSCs) that turn off the immune system, leading to more immune system activity directed at melanoma. (Mehr in: Cancer News — ScienceDaily)

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Trigger, target, trigger: Scientists explore controlled carbon monoxide release

16. Aug. 2018

Scientists have developed flavonoid-based, organic carbon monoxide-releasing molecules that exhibit CO release only when triggered by visible light. Using fluorescence microscopy, the researchers demonstrate targeted CO delivery by the photoCORMs to human lung cancer cells, as well as the ability of the molecules to produce anti-inflammatory effects. (Mehr in: Cancer News — ScienceDaily)

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Childhood exposure to secondhand smoke may increase risk of adult lung disease death

16. Aug. 2018

A new study suggests that long-term exposure to secondhand smoke during childhood increases the risk of chronic obstructive pulmonary disease (COPD) death in adulthood. (Mehr in: Cancer News — ScienceDaily)

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PARP inhibitor improves progression-free survival in patients with advanced breast cancers

15. Aug. 2018

In a randomized, Phase III trial, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes. (Mehr in: Cancer News — ScienceDaily)

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New HIV therapy reduces virus, boosts immunity in drug-resistant patients

15. Aug. 2018

A new HIV drug reduced viral replication and increased immune cells in individuals with advanced, drug-resistant HIV infection. Used in combination with existing HIV medications, the drug is a promising strategy for patients who have run out of effective treatment options, the researchers said. (Mehr in: Cancer News — ScienceDaily)

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The secret behind cell revival revealed

15. Aug. 2018

Scientists identify essential genes for quiescent cells to switch back to dividing mode using fission yeast that may lead to new cancer therapies. (Mehr in: Cancer News — ScienceDaily)

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Scientists discover chemical which can kill glioblastoma cells

15. Aug. 2018

Aggressive brain tumor cells taken from patients self-destructed after being exposed to a chemical in laboratory tests, researchers have shown. (Mehr in: Cancer News — ScienceDaily)

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Light-emitting nanoparticles could provide a safer way to image living cells

15. Aug. 2018

A research team has demonstrated how light-emitting nanoparticles can be used to see deep in living tissue. Researchers hope they can be made to attach to specific components of cells to serve in an advanced imaging system that can pinpoint even single cancer cells. (Mehr in: Cancer News — ScienceDaily)

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A molecular switch may serve as new target point for cancer and diabetes therapies

15. Aug. 2018

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases. (Mehr in: Cancer News — ScienceDaily)

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Chemicals found in vegetables prevent colon cancer in mice

14. Aug. 2018

Chemicals produced by vegetables such as kale, cabbage and broccoli could help to maintain a healthy gut and prevent colon cancer, a new study shows. (Mehr in: Cancer News — ScienceDaily)

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Zombie gene protects against cancer — in elephants

14. Aug. 2018

LIF6, a dead gene that came back to life, prevents cancer by killing cells with DNA damage. (Mehr in: Cancer News — ScienceDaily)

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Potential guidance for gastric cancer treatment

14. Aug. 2018

Researchers have discovered that gastric cancer tissue samples bearing mutation of a specific gene, MUC16, too are associated with higher tumor mutation loads. Also known as tumor mutation burdens, measurement of high genetic mutation rates among cancerous versus healthy tissue has increasingly been shown to correlate with effective response rates to immunotherapy. The knowledge could bode positively for patients with the biomarker present. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

10. TWINCORE Symposium – Frontiers in translational infection research

01. Aug. 2018

Am 31. August 2018 begrüßen wir zum 10. Mal Wissenschaftlerinnen und Wissenschaftler asu der ganzen Welt zum TWINCORE Symposium. Internationale Experten führen durch aktuelle Entwicklungen der translationalen Infektionsforschung.

http://www.twincore.de/twincore/

Nähere Informationen folgen… (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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12th International Conference and Workshop on Biological Barriers

01. Aug. 2018

Biological Barriers is an international scientific event , organized every two years and receiving constantly 200+ registered attendees from all over the world. In the focus of BioBarriers are human cell and tissue models for facilitating clinical translation of new drugs and delivery systems, especially in the context of infectious diseases. Moreover, we will discuss innovative concepts and materials, also capable to overcome non-cellular diffusion barriers such as mucus or bacterial biofilms. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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OSTSEETAG

01. Aug. 2018

Wer Ostsee-Expertenwissen braucht, ist hier richtig: 3. Ostseetag im Stadthafen Rostock! (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Klinische Bewertung medizinischer Software

01. Aug. 2018

Für jedes Medizinprodukt muss der Hersteller anhand klinischer Daten die Eignung für die vorgesehene Verwendung nachweisen und die klinischen Risiken vor dem Hintergrund des zu erwartenden Nutzens für den Patienten bewerten. Dies ist ein kontinuierlicher Prozess, der sich bis zur klinischen Nachbeobachtung nach dem Inverkehrbringen erstreckt. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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„Blue Biotechnology in the Baltic Sea Region – from Science to Business“

01. Aug. 2018

Es ist uns eine große Freude, Sie zu der internationalen Konferenz „Blue Biotechnology in the Baltic Sea Region – from Science to Business“ einzuladen. Rund 100 Wissenschaftler, Unternehmer und Interessenvertreter aus dem Umfeld der marinen Biotechnologie werden vom 22. bis zum 24. August 2018 neueste Resultate aus Forschung und Entwicklung sowie erfolgreiche ökonomische Umsetzungen präsentieren. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Sommerkolleg: Chemie, Physik und Materialwissenschaften

01. Jul. 2018

Das Sommerkolleg bietet Interessierten ab 16 Jahren die Möglichkeit einen vertieften Einblick in das Studium der Chemie und Physik sowie der Materialwissenschaften mit Vorlesungen und Praktika zu gewinnen. Es werden Praktika in der Anorganischen Chemie, der Organischen Chemie, in der Physik, Werkstofftechnik und Umformtechnik angeboten, sowie ein Einführungskurs in die Themenfelder Glas-Bindemittel und Kunststoffverarbeitung. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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RVZ Kolloquium: Prof. Michael Rape

01. Jul. 2018

Prof. Michael Rape from UC Berkeley (US) will talk about his research „The other code: roles of ubiquitin in neuronal development and neurodegeneration“ at the Rudolf Virchow Center of the University of Würzburg. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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