Rainforest vine compound starves pancreatic cancer cells

Pancreatic cancer cells are known for their ability to thrive under extreme conditions of low nutrients and oxygen, a trait known in the cancer field as ‚austerity.‘ The cells‘ remarkable resistance to starvation is one reason why pancreatic cancer is so deadly. Now researchers have identified a compound from a Congolese plant that has strong “antiausterity“ potential, making pancreatic cancer cells susceptible to nutrient starvation. (Mehr in: Cancer News — ScienceDaily)

A 150-year-old drug might improve radiation therapy for cancer

A drug first identified 150 years ago and used as a smooth-muscle relaxant might make tumors more sensitive to radiation therapy. Researchers found that the drug papaverine inhibits the respiration of mitochondria, the oxygen-consuming and energy-making components of cells, and sensitizes model tumors to radiation. They found that the drug does not affect the radiation sensitivity of well-oxygenated normal tissues. (Mehr in: Cancer News — ScienceDaily)

Genetically encoded sensor tracks changes in oxygen levels with very high sensitivity

Based on a protein from E. coli, scientists have developed a fluorescent protein sensor able to provide real-time information on dynamic changes in oxygen levels with very high sensitivity. As the oxygen level is a major determinant of cellular function, the idea behind this sensor may revolutionize our ability to detect cellular changes of critical importance, such as in tumors and following stroke and heart attack. (Mehr in: Cancer News — ScienceDaily)

Disappearing into thin air

In a major advance towards targeting cancer without harming healthy tissue, researchers have found a way to exploit hypoxia (reduced oxygen levels) — a condition which occurs during the development of many common cancers and drives their progression and spread. (Mehr in: Cancer News — ScienceDaily)

Weaponizing oxygen to kill infections and disease

The life-threatening bacteria MRSA can cripple a medical facility since it is resistant to treatment. But scientists report that they are now making advances in a new technique that avoids antibiotics, instead using light to activate oxygen, which wipes out bacteria. The method also could be used to treat other microbial infections, and possibly even cancer. (Mehr in: Cancer News — ScienceDaily)

How nutrients are removed in oxygen-depleted regions of the ocean

Kiel research team describes genetic and evolutionary mechanisms of nitrate reduction from foraminifera for the first time (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

New link between hypoxia and blood clot risk

Researchers have found how hypoxia (a low concentration of oxygen) decreases Protein S, a natural anticoagulant, resulting in an increased risk for the development of potentially life-threatening blood clots (thrombosis). Although hypoxia has been associated with an increased risk for thrombosis, this research showed for the first time a molecular cause. (Mehr in: Cancer News — ScienceDaily)

New study: oxygen loss in the coastal Baltic Sea is “unprecedentedly severe”

The Baltic Sea is home to some of the world’s largest dead zones, areas of oxygen-starved waters where most marine animals can’t survive. But while parts of this sea have long suffered from low oxygen levels, a new study by a team in Finland and Germany shows that oxygen loss in coastal areas over the past century is unprecedented in the last 1500 years. The research is published today in the European Geosciences Union journal Biogeosciences. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

A new tactic for starving tumors

Scientists have found a metabolic particularity in tumor cells that are low on oxygen. The discovery might point to new drugs to target the most difficult-to-treat spots within a tumor. (Mehr in: Cancer News — ScienceDaily)

New defense mechanism against oxygen radicals discovered

Oxygen radicals occur as a by-product when living beings burn carbohydrates or fat. They are suspected of accelerating the ageing process in humans and animals, and to be partly responsible for severe illnesses such as Alzheimer’s or certain types of cancer. Researchers at the University of Bern and the University of Stockholm have now discovered a so far unknown defense mechanism against oxygen radicals which could serve as a base for various medications. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

DGIIN: Vielversprechendes High-Tech-Verfahren bei Lungenversagen

DGIIN fordert differenzierten Einsatz durch erfahrene Intensivmediziner und Intensivpflegekräfte

Berlin, Mai 2018 – Rund 2000 bis 2500 Patienten werden jährlich mit schwersten Lungenversagen mit einer sogenannten extrakorporalen Membranoxygenierung (ECMO) in Kliniken behandelt. Mit diesem Verfahren in der Lungenersatztherapie gelingt es Intensivmedizinern immer häufiger, diese Patienten erfolgreich zu therapieren. Es birgt aber auch Risiken, da es zu erheblichen Komplikationen kommen kann. Die DGIIN betont deshalb wie wichtig es ist, dass dieses hochkomplexe Verfahren durch gut ausgebildete Intensivmediziner und Pflegekräfte durchgeführt wird. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

How might baking soda boost cancer therapy?

A new study has uncovered an entirely novel mechanism by which cells enter a state of dormancy as tissues starved of oxygen become increasingly acidic. (Mehr in: Cancer News — ScienceDaily)

Flavins keep a handy helper in their pocket

Freiburg researchers show for the first time in detail how a flavin-containing enzyme interacts with oxygen (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Cutting off tumor supplies

For a tumour to grow, it must develop blood vessels that supply nutrients and oxygen. Preventing tumor vascularization is therefore an interesting anti-tumor therapy that has been explored over the last ten years. But how to be truly effective? By identifying two cytokines, key factors in the recruitment of blood cells essential to the formation of new blood vessels, and above all by deciphering how these factors interact simultaneously with blood vessels, researchers are now highlighting an additional way of controlling tumor progression. (Mehr in: Cancer News — ScienceDaily)

Microbubbles make breast cancer more susceptible to radiation therapy

Bursting oxygen-filled microbubbles in breast cancer makes tumors three times more sensitive to radiation therapy in preliminary tests with animal models of the disease (Mehr in: Cancer News — ScienceDaily)

Anemia discovery offers new targets to treat fatigue in millions

Researchers have discovered an unknown biological process that controls the production of vital cells that carry oxygen throughout the body. The discovery could help doctors develop new treatments for anemias that affect millions of people. (Mehr in: Cancer News — ScienceDaily)

World’s oldest known oxygen oasis discovered

Tübingen University geoscientists find traces of early oxygen-producing bacteria in 3 billion year old sediments in South Africa’s Pongola Basin (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Discovery of unsuspected flexibility offers new pathway to cancer drug development

Blood vessels are the supply lines of the human body, bringing nutrients and oxygen to cells and carrying away waste. Controlling the growth of these supply lines can be an effective tactic to combat several different types of disorders, including cancer, stroke, and injury. A new study has added layer of nuance to our understanding of the signals that direct blood vessel growth. (Mehr in: Cancer News — ScienceDaily)

MiNT protein a fresh target to attack disease

A potent protein that resides in a cell’s mitochondria is the most recent link to be detailed in a cycle that manages iron and reactive oxygen species. Because the process can be hijacked by cancer and other diseases, the research could lead to new disease-fighting strategies. (Mehr in: Cancer News — ScienceDaily)

Molecular beacon signals low oxygen with ultrasound

Areas of hypoxia, or low oxygen in tissue, are hallmarks of fast-growing cancers and of blockages or narrowing in blood vessels, such as stroke or peripheral artery disease. Researchers have developed a way to find hypoxic spots noninvasively in real time. The researchers developed an oxygen-sensitive molecular beacon that emits ultrasound signals in response to light, a process called photoacoustic imaging. (Mehr in: Cancer News — ScienceDaily)

Encouraging oxygen’s assault on iron may offer new way to kill lung cancer cells

Blocking the action of a key protein frees oxygen to damage iron-dependent proteins in lung and breast cancer cells, making them easier to kill, report investigators. (Mehr in: Cancer News — ScienceDaily)

Scientist at Kiel University receive EU funding to develop new implantats

During a heart attack muscle tissue can be damaged or can even die when cells are not provided with enough oxygen. A research team from Kiel University (CAU) has developed a biomaterial to regenerate and restore harmed tissue and lead to faster treatment. The scientists made use of the fact that cells react to stimuli from their environment. Their material imitates natural cell environments by its structure and consistency. This way the scientists can manipulate the behaviour of cells precisely, specifically they can stimulate the growth of the cells. In a newly-launched project, the research team around Christine Selhuber-Unkel wants to test the commercial viability of the material. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Harder for T cells to fight cancer in absence of VEGF-A

Contrary to what was previously believed, the immune system’s cancer-killing T cells are more effective in a tumor’s anoxic environment when they have access to growth factor VEGF-A. Researchers now show how the T cells not only survive in this oxygen-depleted micro-environment with the help of transcription factor HIF-1a but also become more effective at killing cancer cells inside it. (Mehr in: Cancer News — ScienceDaily)

Plant escape from waterlogging

Researchers at Kiel University have discovered a previously unknown mechanism by which plant roots avoid oxygen-deficient soil

Researchers are warning about more frequently occurring extreme weather events in the future as a result of climate change. Current environmental catastrophes such as the numerous and particularly severe tropical hurricanes this year tend to confirm this trend. These extreme weather events are often accompanied by flooding, which increasingly affects agricultural land. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

MicroRNA helps cancer evade immune system

Researchers have discovered how oxygen-deprived tumors survive body’s immune response, explains a new report. (Mehr in: Cancer News — ScienceDaily)