A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Stammzellen im Fliegenhirn: Forscher entdecken Regulator

Einen Mechanismus, der die asymmetrische Teilung der Stammzellen im Gehirn der Fruchtfliege Drosophila reguliert, entdeckten Wissenschaftler der Arbeitsgruppe um Andreas Wodarz vom Exzellenzcluster CECAD für Alternsforschung. Die Ergebnisse wurden in der Fachzeitschrift „The EMBO Journal“ veröffentlicht. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

A gene required for addictive behavior

Researchers show that mice lacking the Maged1 gene are unable to acquire cocaine addiction

Cocaine can have a devastating effect on people. It directly stimulates the brain’s reward center, and, more importantly, induces long-term changes to the reward circuitry that are responsible for addictive behaviors. Alban de Kerchove d’Exaerde from the Université Libre de Bruxelles, Belgium, and his colleagues have now uncovered that a gene called Maged1 plays a crucial role in controlling these pathological changes. This finding, published today in EMBO Reports, opens the door to further investigations into the molecular mechanisms underlying addiction-associated adaptations in the brain. (Mehr […]

Ein Fall von „Kiss and Tell“: Chromosomales Kissing wird fassbarer

Chromosomen sind im Zellkern unterschiedlich verteilt; ihre Anordnung und Kommunikation miteinander sind bislang kaum verstanden. Forschungsteams aus Berlin und Jena veröffentlichen nun im EMBO Journa,l welchen Effekt strukturelle Chromosomenaberrationen auf die Organisation des Genoms (Chromosomal Kissing) und auf den Krankheitsverlauf haben. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Gefäßerkrankungen: Vorbeugen ist besser als Heilen

Bundesweiter Aktionstag Gefäßgesundheit am 16. Juni 2018

Berlin, 15. Juni 2018. Gefäßerkrankungen wie die Venenthrombose, die Lungenembolie, Krampfadern oder die periphere arterielle Verschlusskrankheit (PAVK), auch bekannt als Schaufensterkrankheit, sind Volkskrankheiten. Doch ihre Anzeichen, ihre Verbreitung und ihre zum Teil dramatischen Folgen sind in der Bevölkerung weitestgehend unbekannt. Deshalb stehen am Aktionstag Gefäßgesundheit am 16. Juni die Aufklärung über diese Krankheiten und die Bedeutung gesunder Gefäße im Fokus. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Cancer: Microbubbles delivered via gas embolotherapy could cut off blood supply and deliver drugs

Embolization — the use of various techniques to cut off the blood vessels that feed tissue growth — has gained traction over the past decades to treat cancerous tumors, and one specific version is gas embolotherapy. During this process, the blood supply is cut off using acoustic droplet vaporization, which uses microscopic gas bubbles induced by exposure to ultrasonic waves. Researchers have discovered that these bubbles could also be used as potential drug delivery systems. (Mehr in: Cancer News — ScienceDaily)

EMBO welcomes Montenegro as its 30th member

Heidelberg, 30 May 2018 – EMBO is pleased to announce that Montenegro has joined its intergovernmental funding body, the European Molecular Biology Conference (EMBC). Montenegro is the 30th country to become part of the EMBC, and will now be able to benefit from the support EMBO offers to talented life science researchers at all career stages. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

COPD associated inflammation halted in model experiment

Chronic obstructive pulmonary disease, or COPD for short, is believed to be the third most common cause of death worldwide. However, because the underlying mechanism is still largely unknown, today’s treatments can only slow progression of the disease. Scientists at Helmholtz Zentrum München have now reported a previously unknown pathogenic mechanism, which they have already been able to prevent in the laboratory. Their findings are reported in ‘EMBO Molecular Medicine’. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Tailoring blood cells in the laboratory

Heidelberg, 26 April 2018 − For some blood transfusion patients, it is particularly difficult to find a compatible blood donor. Growing matching blood cells in the laboratory has long been an overarching goal of scientists for these patients. Research from Ashley Toye and colleagues at the University of Bristol, UK, and NHS Blood and Transplant has brought this vision one step closer to reality. The research is published today in EMBO Molecular Medicine. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

New blood test useful to detect people at risk of developing Alzheimer’s disease

Heidelberg, 6 April 2018 − There is, as yet, no cure for Alzheimer’s disease. It is often argued that progress in drug research has been hampered by the fact that the disease can only be diagnosed when it is too late for an effective intervention. Alzheimer’s disease is thought to begin long before patients show typical symptoms. Scientists have now developed a blood test for Alzheimer’s disease that can detect early indicators of the disease before the first symptoms appear in patients. The blood test would thus offer an opportunity to identify those at risk and may thereby open the […]

Not-for-profit publishers partner to launch new research journal Life Science Alliance

Heidelberg, New York, and Cold Spring Harbor, 3 April 2018 – EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press today announce the launch of Life Science Alliance, a new global, open access, editorially independent, peer-reviewed journal committed to rapid, fair and transparent publication of valuable research from across the life sciences. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Cancer news

The cause of prostate cancer progression to incurable stage has likely been uncovered

20. Jul. 2018

Researchers have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism (SNP) rs11672691 influences prostate cancer aggressiveness. Their findings also suggest ways to improve risk stratification and clinical treatment for advanced prostate cancer. (Mehr in: Cancer News — ScienceDaily)

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Diabetes raises risk of cancer, with women at even greater likelihood, a major new study has found

20. Jul. 2018

A global review involving almost 20 million people has shown that having diabetes significantly raises the risk of developing cancer, and for women the risk is even higher. Researchers also found diabetes (type 1 and type 2) conferred an additional risk for women, compared to men, for leukaemia and cancers of the stomach, mouth and kidney, but less risk for liver cancer. (Mehr in: Cancer News — ScienceDaily)

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Genome damage from CRISPR/Cas9 gene editing higher than thought

19. Jul. 2018

Scientists have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. This has safety implications for future gene therapies using CRISPR/Cas9 as the unexpected damage could lead to dangerous changes in some cells. The study revealed that standard DNA tests miss finding this genetic damage, and that caution and specific testing will be required for any potential gene therapies. (Mehr in: Cancer News — ScienceDaily)

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Discovery of kidney cancer driver could lead to new treatment strategy

19. Jul. 2018

Researchers suggest that ZHX2 is a potential new therapeutic target for clear cell renal cell carcinoma, which is the most common type of kidney cancer. (Mehr in: Cancer News — ScienceDaily)

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Why does making new egg cells require so much cell death?

19. Jul. 2018

A highly detailed study of how the roundworm C. elegans forms oocytes suggests that the egg-making process leads to the formation and subsequent destruction of cells with an extra nucleus, but that some cellular materials are recycled into new eggs. (Mehr in: Cancer News — ScienceDaily)

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Targeting headaches and tumors with nano-submarines

19. Jul. 2018

Scientists have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune cells, which in turn attack tumors. (Mehr in: Cancer News — ScienceDaily)

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High fruit and vegetable consumption may reduce risk of breast cancer

19. Jul. 2018

Women who eat a high amount of fruits and vegetables each day may have a lower risk of breast cancer, especially of aggressive tumors, than those who eat fewer fruits and vegetables, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Sunscreen reduces melanoma risk by 40 per cent in young people

19. Jul. 2018

A world-first study has found that Australians aged 18-40 years who were regular users of sunscreen in childhood reduced their risk of developing melanoma by 40 percent, compared to those who rarely used sunscreen. (Mehr in: Cancer News — ScienceDaily)

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CT scans may increase risk of brain cancer, study suggests

19. Jul. 2018

A new study suggests that CT scans, commonly used in medical imaging, may increase the risk of brain tumors. (Mehr in: Cancer News — ScienceDaily)

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RNA molecules that regulate action of male hormone in prostate cancer identified

18. Jul. 2018

A study detected in tumoral tissue hundreds of RNAs that do not encode proteins but appear to regulate effects of androgens and androgen receptors on gene expression in tumors. By investigating the connection between the presence of these molecules and tumor aggressiveness, the research paves the way for new scientific approaches focusing on the transcription process of noncoding RNA. (Mehr in: Cancer News — ScienceDaily)

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Melanoma biomarkers predicting checkpoint blocker response

18. Jul. 2018

Scientists have identified biomarkers in melanoma that could help tailor immunotherapy treatments to maximize the benefits for patients while reducing the likelihood of severe side effects. (Mehr in: Cancer News — ScienceDaily)

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Scientists uncover DNA ‚shield‘ w/crucial roles in normal cell division

18. Jul. 2018

New fundamental complex in cells drives ‚messy‘ form of DNA repair. In immune cells, this is crucial to make antibodies. In cancer, mutations in complex could lead to resistance to BRCA-targeting PARP inhibitor drugs or platinum chemotherapies. (Mehr in: Cancer News — ScienceDaily)

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Scientists discover a mechanism of drug resistance in breast and ovarian cancer

18. Jul. 2018

A new study helps explain why certain cancers don’t respond to treatment, and offers hope for overcoming this deadly resistance. (Mehr in: Cancer News — ScienceDaily)

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New target protein for colon cancer identified

18. Jul. 2018

Researchers have identified a new potential target protein (c-Cbl) they believe can help further the understanding of colon cancer and ultimately survival of patients with the disease. (Mehr in: Cancer News — ScienceDaily)

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Early supper associated with lower risk of breast and prostate cancer

18. Jul. 2018

People who have their evening meal before 9 p.m. or wait at least two hours before going to sleep have lower risk of breast and prostate cancer. (Mehr in: Cancer News — ScienceDaily)

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Protein found to be key component in irregularly excited brain cells

17. Jul. 2018

In a new study in mice, researchers have identified a key protein involved in the irregular brain cell activity seen in autism spectrum disorders and epilepsy. The protein, p53, is well-known in cancer biology as a tumor suppressor. (Mehr in: Cancer News — ScienceDaily)

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Allergic responses may protect against skin cancer

17. Jul. 2018

The components of the immune system that trigger allergic reactions may also help protect the skin against cancer, suggest new findings. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

Quantum Technology – Impact on Computing and Communication

01. Jul. 2018

Quantum technology forms the technological basis for the development of quantum computers, quantum sensors, quantum cryptography, and quantum communication systems. These technologies have the potential to disrupt a variety of existing industries. For example, quantum computers promise new possibilities for solving computing-intensive or previously not efficiently solvable problems. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Personenzentrierung

01. Jul. 2018

Personenzentrierung: Bausteine für einen heilsamen Umgang bei Menschen mit Demenz zwischen Anspruch und Wirklichkeit. Auch im akademischen Jahr 2017/18 bietet die Philosophisch-Theologische Hochschule Vallendar (PTHV) wieder für die interessierte Öffentlichkeit eine Ringvorlesung an – dieses Mal zum Thema „Heil und Heilung“. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Neue Entwicklungen des Rechts auf Gesundheit in Brasilien

01. Jul. 2018

Die brasilianische Bundesverfassung von 1988 enthält einen großzügigen Katalog sozialer Grundrechte, innerhalb dessen dem Recht auf Gesundheit eine besondere Bedeutung zukommt. Prof. Dr. Ingo Sarlet zeigt die jüngsten Entwicklungen hinsichtlich der Realisierung dieses Rechts auf. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Heilung, Hoffnung, Loslassen. Sorge-Ethik am Lebensende.

01. Jul. 2018

Auch im akademischen Jahr 2017/18 bietet die Philosophisch-Theologische Hochschule Vallendar (PTHV) wieder für die interessierte Öffentlichkeit eine Ringvorlesung an – dieses Mal zum Thema „Heil und Heilung“. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Fachtagung Digitales Management von Patientendaten

01. Jul. 2018

Chancen und Kooperationsmöglichkeiten im Bereich E-Health

Die Tagung richtet sich an Vertreter von Herstellern und Dienstleistern aus dem Umfeld digitaler Lösungen für die Gesundheitsversorgung sowie an Leistungserbringer, Systemadministratoren, Kostenträger, behördliche und politische Entscheidungsträger und allen weiteren Akteuren, die in aktuelle E-Health Entwicklungen involviert sind. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Die Rettung des Nördlichen Breitmaulnashorns

01. Jul. 2018

Wir, das Leibniz-Institut für Zoo- und Wildtierforschung (Leibniz-IZW), laden Sie herzlich zur Pressekonferenz anlässlich der bahnbrechenden Fortschritte in unserem internationalen Forschungsprojekt ein. Wir präsentieren Ihnen die Inhalte einer NATURE COMMUNICATIONS-Publikation. Die Veranstaltung wird vom Springer Nature Verlag moderiert. Als Gäste sind Herr Prof. Dr. Matthias Kleiner, Präsident der Leibniz-Gemeinschaft, und Frau Nina Ruge, UN-Dekade Botschafterin, angefragt. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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build.well.being 2018. A Digital Healthcare Networking Event

01. Jul. 2018

Die Veranstaltung build.well.being am 29. Juni 2018 an der FH St. Pölten stellt innovative Ansätze für das digitalen Gesundheitswesen vor. Das Networking-Event für UmsetzerInnen zeigt konkrete Projekte an der Schnittstelle von Gesundheit und Technik. In knappen drei Stunden präsentieren Studierende und ForscherInnen Streiflichter aus aktueller Praxis und Forschung. Die Veranstaltung richtet sich an Spezialistinnen und Spezialisten im Bereich Digital Healthcare sowie an alle Interessierten. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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