Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Key role found for enzymes in DNA replication and sensitivity to chemotherapeutic drugs

A new study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA. The research is based on previous studies that pointed to TLK1/2 as potential candidate targets in cancer therapy, and it provides new molecular details on their key functions in cancer cell proliferation. (Mehr in: Cancer News — ScienceDaily)

Rhythm of DNA replication exploited to kill cancer cells

Human cells divide and create new cells throughout life. In this process, a steady — even rhythmic — supply of DNA building blocks is needed to create new DNA. Now researchers have shown exactly how human cells regulate this process so it does not fail and cause illness. The researchers also show how they can manipulate the rhythm and suggest how this can be used in the future to kill cancer cells. (Mehr in: Cancer News — ScienceDaily)

The ‚DNA corrector‘ is more efficient in the most important regions of the genome

Error surveillance and repair mechanisms during DNA replication do not show the same competence in all regions of the human genome. Scientists have discovered that the mechanism that repairs errors in DNA is more efficient in the regions of genes that hold information for the production of proteins. (Mehr in: Cancer News — ScienceDaily)

Problems with DNA replication can cause epigenetic changes that may be inherited for several generations

Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to five generations. They also identified the cause of these epigenetic changes, which is related to the loss of a molecular mechanism in charge of silencing genes. Their results will change the way we think about the impact of replication stress in cancer and during embryonic development, as well as its inter-generational inheritance. (Mehr in: Cancer News — ScienceDaily)

Squeezing life from DNA’s double helix

DNA replication begins when the double helix, caught in a vice of proteins, melts, scientists have discovered. (Mehr in: Cancer News — ScienceDaily)

Structure of key DNA replication protein solved

A research team has solved the three-dimensional structure of a key protein that helps damaged cellular DNA repair itself. Investigators say that knowing the chemical structure of the protein will likely help drug designers build novel anti-cancer agents. (Mehr in: Cancer News — ScienceDaily)

DNA Replication – Take a break

Before a cell divides, it must first handle a large-scale project: Its entire genetic material has to be duplicated so that each of the two daughter cells is equipped with a full copy after cell division. As errors in this DNA replication could lead to the death of the cell, the process is rigorously controlled. It takes place in two phases. Researchers at the Max Planck Institute of Biochemistry in Martinsried have now revealed in the journal Cell Reports that these two phases are strictly separated from one another by breaks, thereby preventing errors in the DNA replication. (Mehr in: […]

Enzyme with high potential for new cancer treatment identified

A team of researchers has identified an enzyme that separates DNA replication from repair. This discovery could be of tremendous significance in the treatment of tumors. (Mehr in: Cancer News — ScienceDaily)

Chromosomes: the importance of keeping the balance

The genetic material of cancer cells is unstable. For example, the number of chromosomes, which are the individual elements of packed DNA, is changed in so called aneuploidies. This imbalance in chromosomes, which often occurs early in tumor development, leads to cell stress and promotes disease. How this can happen is now shown by the discovery of a research team led by Zuzana Storchová at the Max Planck Institute of Biochemistry in Martinsried, reported in a groundbreaking study published in Nature Communications. An imbalance in an enzyme called MCM2-7 that is essential for DNA replication is likely to be responsible […]

Researchers connect haywire protein to breast cancer, leukemia

The cause of some cancers, including breast cancer and leukemia, is better understood, thanks to recent research. In the new study, the researchers found that too much of a key protein, called cyclin E, slows down DNA replication and introduces potentially harmful cancer-linked mutations when cells divide. (Mehr in: Cancer News — ScienceDaily)

Cancer news

New cell movement process key to understanding and repairing facial malformations

18. Okt. 2018

The embryonic stem cells that form facial features, called neural crest cells, use an unexpected mechanism of moving from the back of the head to the front to populate the face, finds a new study. (Mehr in: Cancer News — ScienceDaily)

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Big-picture approach to understanding cancer will speed new treatments

18. Okt. 2018

The new approach lets scientists examine the cumulative effect of multiple gene mutations, providing a much more complete picture of cancers‘ causes. (Mehr in: Cancer News — ScienceDaily)

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Genome sequencing found feasible and informative for pediatric cancer treatment

18. Okt. 2018

Comprehensive genetic testing of tumors and non-cancerous tissue from pediatric cancer patients is a feasible and clinically useful approach that can guide patient care, according to new findings. (Mehr in: Cancer News — ScienceDaily)

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A 150-year-old drug might improve radiation therapy for cancer

17. Okt. 2018

A drug first identified 150 years ago and used as a smooth-muscle relaxant might make tumors more sensitive to radiation therapy. Researchers found that the drug papaverine inhibits the respiration of mitochondria, the oxygen-consuming and energy-making components of cells, and sensitizes model tumors to radiation. They found that the drug does not affect the radiation sensitivity of well-oxygenated normal tissues. (Mehr in: Cancer News — ScienceDaily)

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Vast leukemia dataset could help researchers match therapies to patients

17. Okt. 2018

Data on the molecular makeup and drug sensitivity of hundreds of patient samples could accelerate progress against the aggressive blood cancer acute myeloid leukemia. (Mehr in: Cancer News — ScienceDaily)

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Breastfeeding protects infants from antibiotic-resistant bacteria

17. Okt. 2018

A new study shows that infants that are breastfed for at least six months have less antibiotic-resistant bacteria in their gut compared with babies breastfed for a shorter time. On the other hand, antibiotic use by mothers increases the number of antibiotic-resistant bacteria in infants. (Mehr in: Cancer News — ScienceDaily)

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Lymphatic system, key player in human health

16. Okt. 2018

Defects in the lymphatic system have been linked to a wide range of health consequences, but new findings of how the system works could lead to future therapies. (Mehr in: Cancer News — ScienceDaily)

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Age-related increase in estrogen may cause common men’s hernia

16. Okt. 2018

An age-related increase in estrogen may be the culprit behind inguinal hernias, a condition common among elderly men that often requires corrective surgery. Men could be treated with hormone inhibitor to strengthen muscle, the researcher suggests. (Mehr in: Cancer News — ScienceDaily)

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This RNA-based technique could make gene therapy more effective

16. Okt. 2018

Biological engineers have devised a way to regulate the expression of messenger RNA once it gets into cells, giving them more precise control over gene therapy treatments for cancer and other diseases. (Mehr in: Cancer News — ScienceDaily)

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A bad influence: Interplay between tumor cells and immune cells

16. Okt. 2018

Research has yielded new insights into the environment surrounding different types of lung tumors, and described how these complex cell ecosystems may in turn ultimately affect response to treatment. (Mehr in: Cancer News — ScienceDaily)

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Automated system identifies dense tissue, a risk factor for breast cancer, in mammograms

16. Okt. 2018

Researchers have developed an automated model that assesses dense breast tissue in mammograms — which is an independent risk factor for breast cancer — as reliably as expert radiologists. This marks the first time a deep-learning model of its kind has successfully been used in a clinic on real patients, according to the researchers. With broad implementation, the researchers hope the model can help bring greater reliability to breast density assessments across the nation. (Mehr in: Cancer News — ScienceDaily)

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Diets rich in fish oil could slow the spread and growth of breast cancer cells

16. Okt. 2018

Omega-3 fatty acids, such as those typically contained in fish oil, may suppress the growth and spread of breast cancer cells in mice. (Mehr in: Cancer News — ScienceDaily)

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New way to determine whether metastatic cancer cells in breast cancer patients are dormant or soon to turn deadly

16. Okt. 2018

For the first time ever, researchers have identified a protein as a marker that can indicate whether a cancer patient will develop a recurrence of lethal, metastatic cancer. (Mehr in: Cancer News — ScienceDaily)

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Finding better drug ‚fits,‘ avoiding medication tragedies like thalidomide

15. Okt. 2018

Researchers, including chemistry professor and Nobel Prize winner Ei-ichi Negishi, have developed technology to create a new chemical process to synthesize drug-like molecules with ultra-high purity. (Mehr in: Cancer News — ScienceDaily)

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3D mammography detected 34 percent more breast cancers in screening

15. Okt. 2018

After screening 15,000 women over a period of five years, a major clinical study in Sweden has shown that 3D mammography, or breast tomosynthesis, detects over 30% more cancers compared to traditional mammography — with a majority of the detected tumors proving to be invasive cancers. (Mehr in: Cancer News — ScienceDaily)

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More clues revealed in link between normal breast changes and invasive breast cancer

15. Okt. 2018

A research team details how a natural and dramatic process — changes in mammary glands to accommodate breastfeeding — uses a molecular process believed to contribute to survival of pre-malignant breast cells. (Mehr in: Cancer News — ScienceDaily)

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Cells‘ route in response to disease is not always straight

15. Okt. 2018

The steps cells take in response to challenges are more complex than previously thought, finds new research. The study investigates a system relevant to cancer, viral infection, and diabetes. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

13. ITG Fachtagung Sprachkommunikation

09. Okt. 2018

Die Tagung der Informationstechnischen Gesellschaft (ITG), einer Fachgesellschaft des Verbands der Elektrotechnik, Elektronik, Informationstechnik (VDE), ist eins der größten Treffen von Wissenschaftlern und Praktikern auf dem Gebiet der Sprachverarbeitung im deutschsprachigen Raum. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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62. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V.

01. Okt. 2018

Bereits zum zweiundsechzigsten Mal findet 2018 der Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V. statt. Vom 31. Oktober bis 3. November diskutieren über 5.000 Expertinnen und Experten im Berliner CityCube den aktuellen Stand der Wissenschaft und Forschung sowie die Zukunft des Fachgebiets der Frauenheilkunde und Geburtshilfe. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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5th International Conference on Cellular Materials (CellMAT), 24 – 26 October

01. Okt. 2018

The 5th CellMAT conference will cover all aspects of manufacturing, functionalizing, modification, joining, property analysis and modelling of cellular materials. In addition to this, featured side events will focus on specific topics. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Einführung in die additive Fertigung

01. Okt. 2018

Das Thema additive Fertigung, d.h. der direkte schichtweise Aufbau von Produkten, ist aktuell sehr stark in das Interesse der polymer- und metallverarbeitenden Industrie sowie des produzierenden Gewerbes gerückt. Allein basierend auf 3D-Konstruktionsdaten können auf verschiedene Weisen Bauteile mit integrierten Funktionalitäten ohne Verwendung eines Werkzeuges realisiert werden, die konventionell so nicht herstellbar sind. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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CISCEM 2018 – 4th International Conference on In Situ and Correlative Electron Microscopy

01. Okt. 2018

CISCEM aims at bringing together an interdisciplinary group of scientists from the fields of biology, materials science, chemistry, and physics, to discuss future directions of in-situ electron microscopy research. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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BfR-Akademie Fortbildung: Transfer von Stoffen entlang der Nahrungskette – Teil 2

01. Okt. 2018

https://www.bfr-akademie.de/deutsch/veranstaltungen/transfer2.html (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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7T and beyond: 12th Erwin L. Hahn Lecture

01. Okt. 2018

Höher, schneller, weiter – die immer größer werdenden Feldstärken der MRTs erlauben einmalige und faszinierend detaillierte Aufnahmen aus dem Innern des menschlichen Körpers. Aber bringt die Ultra-Hochfeld-MRT auch Nachteile mit sich? Welchen Schwierigkeiten sehen sich die Forscher und Mediziner bei solch hohen Magnetfeldstärken ausgesetzt? Mit diesen und anderen Fragen beschäftigt sich die diesjährige Erwin L. Hahn Workshop & Lecture unter dem Thema „7T and Beyond“. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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