Important aging mechanism in fish model Nothobranchius furzeri revealed

Nothobranchius furzeri, the African killifish, is the perfect model organism for research into aging processes because of its short lifespan, apparent signs of aging and a sequenced genome. Thus, researchers from the University of Veterinary Medicine Vienna and the Medical University of Vienna were able to show that histone deacetylases, which are important for cell cycle regulation are produced less in aging fish. In parallel, the team confirmed this aging mechanism in mice. The identification of epigenetic and thus, reversible changes could be a loophole to develop active compounds antagonising the aging process. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)