Haemophiliacs and their treatment – danger signals involved in immune response against factor-VIII

In patients with haemophilia A, the missing blood coagulation factor VIII is administered, and thus replaced, intravenously. A part of the patients, however, develops antibodies (inhibitors) against factor VIII, which, in the worst case scenario, can cause uncontrolled bleeding. Researchers of the Paul-Ehrlich-Institut (PEI) have now established that the adverse immune reactions occur in the presence of so-called danger signals. After antigen processing, mainly memory T cells are activated. The results are published in Thromb. Haemost. in its online edition of 19 March 2018. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)