Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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„Wohlstandserkrankung“ Diabetes in Afrika: Betroffene haben kaum Zugang zu Diagnose und Behandlung

Auswertung von Daten aus zwölf Ländern südlich der Sahara zeigt: Fast alle Diabetes-Patienten werden nicht aureichend behandelt; vor allem Menschen mit geringer Ausbildung und Junge wissen oft nichts von ihrer Erkrankung; Versorgungsstrukturen und Präventionsstrategien fehlen. Forscher um den Humboldt-Professor und neuen Leiter des Instituts für Public Health am Universitätsklinikum Heidelberg, Prof. Dr. Dr. Till Bärnighausen veröffentlichen ihre Arbeit im Fachmagazin The Lancet Diabetes & Endocrinology (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

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Cancer news

Wider sampling of tumor tissues may guide drug choice, improve outcomes

15. Nov. 2017

By focusing on genetic variations within a primary tumor, differences between the primary and a metastatic tumor, and additional diversity from tumor DNA in the blood stream, physicians can make better treatment choices for patients with gastric and esophageal adenocarcinoma. This study challenges current guidelines and supports evaluation of metastatic lesions and circulating tumor DNA. (Mehr in: Cancer News — ScienceDaily)

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Key to unlock blocked differentiation in microRNA-deficient embryonic stem cells

15. Nov. 2017

Scientists have partly solved a long-unanswered basic question about stem cells — why are pluripotent stem cells that have mutations to block the production of microRNAs unable to differentiate? (Mehr in: Cancer News — ScienceDaily)

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Development of new protein may lead to novel treatment options for cancer, birth defects

14. Nov. 2017

An artificial protein has been engineered that may block malignant properties of cancer cells as well as correct certain birth defects. The findings may lead to identifying new molecular targets suitable for therapeutic intervention. (Mehr in: Cancer News — ScienceDaily)

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Why testicular cancer is so responsive to chemo

14. Nov. 2017

A major step has been taken toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it metastasizes? (Mehr in: Cancer News — ScienceDaily)

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Sensor for the most important human cancer gene

14. Nov. 2017

The molecular smoke detector works like a TP53 sensor, which monitors the correct function of the gene. A non-functional TP53 gene is going to activate the sensor, which initiates cell death. (Mehr in: Cancer News — ScienceDaily)

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Tapeworm drug fights prostate cancer

14. Nov. 2017

Medicine against parasites like Tapeworms and Giardia, contains a substance that kills Prostate- and colon cancer, scientists have discovered. (Mehr in: Cancer News — ScienceDaily)

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HPV testing is better than the Pap test at detecting cervical cancer

14. Nov. 2017

Testing for cervical cancer using HPV testing in addition to the Pap smear is unlikely to detect cancer cases that wouldn’t be found using HPV testing alone. (Mehr in: Cancer News — ScienceDaily)

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Insurance linked to black-white survival disparities in colorectal cancer

14. Nov. 2017

Health insurance coverage differences account for nearly one-half of the black-white survival disparity in colorectal cancer patients, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Effective therapy against glioblastoma by attacking telomeres

13. Nov. 2017

Researchers have shown that it is possible to block the growth of human and murine glioblastoma in mouse models by blocking the TRF1 protein; an essential component of the telomere-protective complex. The study describes a new and promising way to combat this type of brain tumor by attacking its ability to regenerate and divide immortally. (Mehr in: Cancer News — ScienceDaily)

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Genes that hold the clues to bladder cancer and its treatment

13. Nov. 2017

Scientists have discovered the ‚genetic signatures‘ of the most common form of bladder cancer — and it could open up the possibility of better-targeted treatment. (Mehr in: Cancer News — ScienceDaily)

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Harder for T cells to fight cancer in absence of VEGF-A

13. Nov. 2017

Contrary to what was previously believed, the immune system’s cancer-killing T cells are more effective in a tumor’s anoxic environment when they have access to growth factor VEGF-A. Researchers now show how the T cells not only survive in this oxygen-depleted micro-environment with the help of transcription factor HIF-1a but also become more effective at killing cancer cells inside it. (Mehr in: Cancer News — ScienceDaily)

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Engineering non-immune cells to kill cancer cells

13. Nov. 2017

Researchers have reprogrammed normal human cells to create designer immune cells capable of detecting and destroying cancer cells. (Mehr in: Cancer News — ScienceDaily)

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Epigenetic editing reveals surprising insights into early breast cancer development

13. Nov. 2017

Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to begin a chain reaction and become abnormal, according to new research. (Mehr in: Cancer News — ScienceDaily)

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Cancer immunotherapy uses melanin against melanoma

10. Nov. 2017

Researchers have developed a melanin-enhanced cancer immunotherapy technique that can also serve as a vaccine, based on early experiments done in a mouse model. The technique is applied via a transdermal patch. (Mehr in: Cancer News — ScienceDaily)

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Mutant gene network in colon cancer identified

10. Nov. 2017

The principles of the gene network for colon tumorigenesis have been identified. The principles will be used to find the molecular target for effective anti-cancer drugs in the future. Further, this research gained attention for using a systems biology approach, which is an integrated research area of IT and BT. (Mehr in: Cancer News — ScienceDaily)

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Novel mechanism by which tumors evade cancer immunotherapies

10. Nov. 2017

A new study has identified a novel mechanism by which tumors of the aggressive skin cancer melanoma can resist cancer immunotherapy. (Mehr in: Cancer News — ScienceDaily)

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Chinese medicine scholars develop novel targeted delivery system for CRISPR/Cas9

10. Nov. 2017

Chinese Medicine scholars have succeeded in developing a novel targeted delivery system for CRISPR/Cas9 to achieve therapeutic genome editing of VEGFA in osteosarcoma (OS). (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

6. Morbi-RSA Symposium

01. Nov. 2017

Eigentlich soll der morbiditätsorientierte Risikostrukturausgleich – kurz: Morbi-RSA – den Finanzausgleich zwischen den gesetzlichen Krankenversicherungen regeln. Fakt ist: Die Kassen haben nach wie vor die Möglichkeit, ärztliche Diagnosen zu beeinflussen, um so höhere Zuwendungen aus dem Gesundheitsfonds zu erreichen. Das geht aus einem Gutachten des Berliner IGES Instituts hervor – und liefert jede Menge Zündstoff für das 6. Morbi-RSA Symposium am 20. November 2017 in Essen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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20. Gesundheitspolitisches Kolloquium

01. Nov. 2017

Wer übernimmt die Verantwortung in der Notfallversorgung? 20. Gesundheitspolitisches Kolloquium an der Frankfurt UAS diskutiert Optionen der Notfallversorgung in Hessen (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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20. Deutsche Mukoviszidose Tagung

01. Nov. 2017

Biomarker im klinischen Alltag, Problemkeime jenseits des Pseudomonas, die Bedeutung von Physiotherapie in der Mukoviszidose-Behandlung – dies sind nur einige Beispiele für das breite Themenspektrum der Deutschen Mukoviszidose Tagung, die vom 16. bis 18. November 2017 in Würzburg stattfindet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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13. Kolloquium Prozessanalytik: Prozessführung in der modernen Produktion

01. Nov. 2017

Was kann die Prozessindustrie im Hinblick auf die „Industrie 4.0“ von der Fertigungstechnik lernen? Mit dieser Frage schlägt das 13. Kolloquium „Prozessanalytik“ die Brücke zwischen zwei technologischen Bereichen, die für die chemisch/pharmazeutische Prozessindustrie aktueller denn je sind. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Biologisierung der Medizintechnik – Workshop VII – Biomaterial – Immunsystem Wechselwirkungen

01. Nov. 2017

Wechselwirkungen zwischen Biomaterialien und dem Organismus können zu Problemen führen oder Chancen eröffnen. Die Einflüsse reichen vom Biofouling während des Erstkontaktes bis hin zu Implantatverlusten. Eine zentrale Rolle spielt das Immunsystem, das viele dieser Reaktionen koordiniert. Ziel ist es deshalb, ein rationales Design von Biomaterialien mit immunmodulierenden Eigenschaften zu erreichen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Akademievorlesung "Willkommen in Utopia." | 16.11.2017 18:00 Uhr – 20:00 Uhr

01. Nov. 2017

Mit der Akademievorlesung zieht die Interdisziplinare Arbeitsgruppe „Gentechnologiebericht“ 16 Jahre nach ihrer Gründung Bilanz anlässlich eines heute wie damals höchst umstrittenen und viel diskutierten Forschungsbereichs. In Expertenbeiträgen und Podiumsdiskussionen werden die Gentechnologien dabei sowohl in ihrer historischen und zukünftigen Entwicklung als auch in ihrer aktuellen gesellschafts- und forschungspolitischen Relevanz eingeordnet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Akademievorlesung "Wie werden Gentechnologien kontrolliert?" | 09.11.2017 18:00 Uhr – 21:00 Uhr

01. Nov. 2017

Mit der Akademievorlesung zieht die Interdisziplinare Arbeitsgruppe „Gentechnologiebericht“ 16 Jahre nach ihrer Gründung Bilanz anlässlich eines heute wie damals höchst umstrittenen und viel diskutierten Forschungsbereichs. In Expertenbeiträgen und Podiumsdiskussionen werden die Gentechnologien dabei sowohl in ihrer historischen und zukünftigen Entwicklung als auch in ihrer aktuellen gesellschafts- und forschungspolitischen Relevanz eingeordnet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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