A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Algorithmen eröffnen Einblicke in die Zellentwicklung

Neuherberg, 31. August 2016. Durch RNA-Sequenzierung können Forscher messen, welche Gene in jeder einzelnen Zelle einer Probe abgelesen werden. Eine neue statistische Methode erlaubt es, so aus einem Zellgemisch unterschiedliche Entwicklungsprozesse herauszulesen, die nebeneinander ablaufen. Das berichten Forscherinnen und Forscher des Helmholtz Zentrums München in Zusammenarbeit mit Kollegen der Technischen Universität München in ‚Nature Methods‘. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

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Cancer news

Molecular beacon signals low oxygen with ultrasound

08. Dez. 2017

Areas of hypoxia, or low oxygen in tissue, are hallmarks of fast-growing cancers and of blockages or narrowing in blood vessels, such as stroke or peripheral artery disease. Researchers have developed a way to find hypoxic spots noninvasively in real time. The researchers developed an oxygen-sensitive molecular beacon that emits ultrasound signals in response to light, a process called photoacoustic imaging. (Mehr in: Cancer News — ScienceDaily)

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Including diagnosis related costs, 3-D mammography costs less than digital mammography

08. Dez. 2017

Although digital breast tomosynthesis (DBT), or 3-D mammography, costs more than a digital mammography (DM) screening, it actually may help rein in cancer screening costs, according to preliminary findings. (Mehr in: Cancer News — ScienceDaily)

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Novel compound restores immune response in patients with melanoma

08. Dez. 2017

A novel compound may restore immune response in patients with melanoma, according to a study presented at the ESMO Immuno Oncology Congress 2017. (Mehr in: Cancer News — ScienceDaily)

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Time matters: Does our biological clock keep cancer at bay?

07. Dez. 2017

Our body has an internal biological or ‚circadian‘ clock, which cycles daily and is synchronized with solar time. New research done in mice suggests that it can help suppress cancer. (Mehr in: Cancer News — ScienceDaily)

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Novel harvesting method rapidly produces superior stem cells for transplantation

07. Dez. 2017

A new method of harvesting stem cells for bone marrow transplantation may make the donation process more convenient and less unpleasant for donors while providing cells that are superior to those acquired by current protocols. (Mehr in: Cancer News — ScienceDaily)

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Mechanism identified behind enzyme involved in liver and other human cancers

07. Dez. 2017

To understand what has gone wrong when cancer occurs and to create new possibilities for treatment, it is important to understand the molecular mechanisms behind what is happening at the cellular level. New research explains how the motor of an enzyme in DNA damage repair is switched on and off and how these processes might go awry in cancer. (Mehr in: Cancer News — ScienceDaily)

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Novel pathway to suppress virus-induced cancers

07. Dez. 2017

Researchers have identified a novel molecular pathway by which a tumor suppressor, TIP60, inhibits the growth of cancer cells. The study paves the way for the development of new therapeutic strategies that could impede the spread of virus-induced cancers. (Mehr in: Cancer News — ScienceDaily)

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First line combination therapy improves progression-free survival in advanced lung cancer

07. Dez. 2017

A new combination therapy for the first line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) improves progression-free survival (PFS), according to results of a phase III IMpower150 trial. (Mehr in: Cancer News — ScienceDaily)

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Contrast-enhanced digital mammography comparable to breast MRI after therapy or chemo

07. Dez. 2017

Contrast-enhanced digital mammography is comparable to breast MRI in evaluating residual breast cancer after neoadjuvant endocrine therapy or chemotherapy, according to new results. (Mehr in: Cancer News — ScienceDaily)

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Novel regulation of gene expression in brain tumors identified

06. Dez. 2017

New study results reveal a previously unknown interplay between two key enzymes and a novel understanding of how brain cancer tumors form and spread. (Mehr in: Cancer News — ScienceDaily)

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Go with the flow (or against it)

06. Dez. 2017

Researchers are using magnetic fields to influence a specific type of bacteria to swim against strong currents, opening up the potential of using the microscopic organisms for drug delivery in environments with complex microflows- – like the human bloodstream. (Mehr in: Cancer News — ScienceDaily)

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Dibenzoazepine defender: Drug found to be effective against resistant hepatitis C

06. Dez. 2017

Researchers have identified a class of chemicals that can combat resistant strains of the hepatitis C virus, as well as parasites that cause malaria and toxoplasmosis. (Mehr in: Cancer News — ScienceDaily)

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Is laughter the greatest medicine for cancer patients?

06. Dez. 2017

Spontaneous humor is used and appreciated by people with cancer and can be a helpful way of dealing with distressing, taboo or embarrassing circumstances, research shows. (Mehr in: Cancer News — ScienceDaily)

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Screening has had ‚little impact‘ on falling breast cancer deaths in the Netherlands, study suggests

06. Dez. 2017

Breast screening in the Netherlands seems to have had a marginal effect on breast cancer mortality over the past 24 years, suggests research. (Mehr in: Cancer News — ScienceDaily)

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Blood test could help predict skin cancer’s return

06. Dez. 2017

Testing skin cancer patients‘ blood for tumor DNA could help predict the chances of an aggressive cancer returning, scientists have discovered. (Mehr in: Cancer News — ScienceDaily)

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In multiple myeloma, high levels of enzyme ADAR1 are associated with reduced survival

05. Dez. 2017

Using a database of multiple myeloma patient samples and information, researchers found that high ADAR1 levels correlate with reduced survival rates. They also determined that blocking the enzyme reduces multiple myeloma regeneration in experimental models derived from patient cancer cells. (Mehr in: Cancer News — ScienceDaily)

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New weakness found in most common childhood malignant brain tumor

05. Dez. 2017

A new weakness found in medulloblastoma, the most common form of childhood brain tumor, could lead to more personalized medicine and improved treatment for some patients, according to an early study. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

12. Jahrestagung der Deutschen Wirbelsäulengesellschaft (DWG)

20. Nov. 2017

Der diesjährige Schwerpunkt des Kongresses liegt auf den Themen Trauma und Tumor in der Wirbelsäulenchirurgie. Wichtige wissenschaftliche Beiträge zu Tumorerkrankungen, degenerativen Erkrankungen, entzündlichen und metabolischen Erkrankungen, Verletzungen und Deformitäten aber auch zu innovativen Techniken erwarten die Besucherinnen und Besucher. Dabei steht ein fächerübergreifender Ansatz im Vordergrund, denn auch auf dem Gebiet der Wirbelsäulenheilkunde gilt es, Bewährtes zu erhalten und gleichzeitig neuen Behandlungsmethoden gegenüber offen zu sein. Dass die Deutsche Wirbelsäulengesellschaft diesen Anspruch ernst nimmt, zeigt auch die Zentren-Zertifizierung, die in diesem Jahr gestartet wurde. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Biologisierung der Medizintechnik – Workshop VII – Biomaterial – Immunsystem Wechselwirkungen

01. Nov. 2017

Wechselwirkungen zwischen Biomaterialien und dem Organismus können zu Problemen führen oder Chancen eröffnen. Die Einflüsse reichen vom Biofouling während des Erstkontaktes bis hin zu Implantatverlusten. Eine zentrale Rolle spielt das Immunsystem, das viele dieser Reaktionen koordiniert. Ziel ist es deshalb, ein rationales Design von Biomaterialien mit immunmodulierenden Eigenschaften zu erreichen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Akademievorlesung "Willkommen in Utopia." | 16.11.2017 18:00 Uhr – 20:00 Uhr

01. Nov. 2017

Mit der Akademievorlesung zieht die Interdisziplinare Arbeitsgruppe „Gentechnologiebericht“ 16 Jahre nach ihrer Gründung Bilanz anlässlich eines heute wie damals höchst umstrittenen und viel diskutierten Forschungsbereichs. In Expertenbeiträgen und Podiumsdiskussionen werden die Gentechnologien dabei sowohl in ihrer historischen und zukünftigen Entwicklung als auch in ihrer aktuellen gesellschafts- und forschungspolitischen Relevanz eingeordnet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Akademievorlesung "Wie werden Gentechnologien kontrolliert?" | 09.11.2017 18:00 Uhr – 21:00 Uhr

01. Nov. 2017

Mit der Akademievorlesung zieht die Interdisziplinare Arbeitsgruppe „Gentechnologiebericht“ 16 Jahre nach ihrer Gründung Bilanz anlässlich eines heute wie damals höchst umstrittenen und viel diskutierten Forschungsbereichs. In Expertenbeiträgen und Podiumsdiskussionen werden die Gentechnologien dabei sowohl in ihrer historischen und zukünftigen Entwicklung als auch in ihrer aktuellen gesellschafts- und forschungspolitischen Relevanz eingeordnet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Akademievorlesung "Gentechnologien damals, heute und morgen" | 02.11.2017 18:00 Uhr – 21:00 Uhr

01. Nov. 2017

Mit der Akademievorlesung zieht die Interdisziplinare Arbeitsgruppe „Gentechnologiebericht“ 16 Jahre nach ihrer Gründung Bilanz anlässlich eines heute wie damals höchst umstrittenen und viel diskutierten Forschungsbereichs. In Expertenbeiträgen und Podiumsdiskussionen werden die Gentechnologien dabei sowohl in ihrer historischen und zukünftigen Entwicklung als auch in ihrer aktuellen gesellschafts- und forschungspolitischen Relevanz eingeordnet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Air Pollution and Health: New Research Perspectives for a Growing Global Crisis

01. Nov. 2017

Joint symposium by the Academy of Science of South Africa and the Leopoldina (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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6. Morbi-RSA Symposium

01. Nov. 2017

Eigentlich soll der morbiditätsorientierte Risikostrukturausgleich – kurz: Morbi-RSA – den Finanzausgleich zwischen den gesetzlichen Krankenversicherungen regeln. Fakt ist: Die Kassen haben nach wie vor die Möglichkeit, ärztliche Diagnosen zu beeinflussen, um so höhere Zuwendungen aus dem Gesundheitsfonds zu erreichen. Das geht aus einem Gutachten des Berliner IGES Instituts hervor – und liefert jede Menge Zündstoff für das 6. Morbi-RSA Symposium am 20. November 2017 in Essen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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