Scientists reveal the relationship between sugar, cancer

A nine-year joint research project has led to a crucial breakthrough in cancer research. Scientists have clarified how the Warburg effect, a phenomenon in which cancer cells rapidly break down sugars, stimulates tumor growth. This discovery provides evidence for a positive correlation between sugar and cancer, which may have far-reaching impacts on tailor-made diets for cancer patients. (Mehr in: Cancer News — ScienceDaily)

Metabolism drives growth, division of cancer cells

The metabolic state of tumor cells contributes to signals that control the proliferation of tumor cells. In the 1920s, scientists observed that tumor cells radically change their metabolism. This process was termed „Warburg Effect“, however neglected until recently by cancer research, but the latest results show it is indeed of fundamental importance for the development of aggressive tumors. (Mehr in: Cancer News — ScienceDaily)

Metabolism drives growth and division of cancer cells

Already the Nobel Prize laureate Otto H. Warburg observed in the 1920s that tumor cells radically change their metabolism. This process was termed „Warburg Effect“, however neglected until recently by cancer research, but the latest results show it is indeed of fundamental importance for the development of aggressive tumors. Richard Moriggl and co-workers now published in the journal Leukemia how the tumor promoter STAT5 integrates metabolic signals that contribute to oncogenic transformation. Researchers from the VetmeduniVienna, Ludwig Boltzmann Institute for Cancer Research and Meduni Wien may have thus identified a new target to tackle cancer. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Nutty stimulant revealed as anticancer tool

Arecoline, a component in areca nuts, is analogous to nicotine, say scientists. Areca nuts are chewed for their stimulant effects in many Asian countries, and evidence links the practice to the development of oral and esophageal cancer. Analogous to nicotine, arecoline was identified as an inhibitor of the enzyme ACAT1, which contributes to the metabolism-distorting Warburg effect in cancer cells. (Mehr in: Cancer News — ScienceDaily)

Potential new class of cancer drugs developed in lab

A new class of drug developed targets the Warburg effect to cut off cancer’s energy supply, and researchers say that it has the potential to stop most kinds of cancer in its tracks. (Mehr in: Cancer News — ScienceDaily)

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection.

Warburg O, Posener K, Negelein E. (1924) Über den Stoffwechsel der Carcinomzelle. Biochem Z. 152, 309–344.