A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

[ read more ]

Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

[ read more ]

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

[ read more ]

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

[ read more ]

Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

[ read more ]

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

[ read more ]

Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

[ read more ]

Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

[ read more ]

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

[ read more ]

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

[ read more ]

Back to the future: breast cancer reprises pathways found in fetal cells

Scientists have uncovered a reason for the uncanny likeness between cells in the most malignant cancers and the embryonic cells of the organ in which the cancer originated: cells in human basal-like breast cancers share features with the embryonic mammary (breast) stem cells that are the progenitors of all cell types in the mammary gland (of a mouse). (Mehr in: Cancer News — ScienceDaily)

New research opens door to expanding stem cells available for transplants

Researchers have identified a way to expand blood-forming, adult stem cells from human umbilical cord blood (hUCB). (Mehr in: Cancer News — ScienceDaily)

Origin cells for deadly brain tumors identified

A new study identified where the mutation causing glioblastoma starts. According to the study, neural stem cells away from the tumor mass are the cells of origin that contain mutation drivers for glioblastoma, one of the most aggressive brain tumor. This breakthrough research gives insights for understanding why glioblastomas almost always grow back, even after surgery, and suggests novel ways to treat glioblastoma, which was previously thought to be incurable. (Mehr in: Cancer News — ScienceDaily)

Nowhere to hide: Molecular probe illuminates elusive cancer stem cells in live mice

After a primary tumor is treated, cancer stem cells may still lurk in the body, ready to metastasize and cause a recurrence of the cancer in a form that’s more aggressive and resistant to treatment. Researchers have developed a molecular probe that seeks out these elusive cells and lights them up so they can be identified, tracked and studied not only in cell cultures, but in their native environment: the body. (Mehr in: Cancer News — ScienceDaily)

Scientists create nano-size packets of genetic code aimed at brain cancer ‚seed‘ cells

In a ‚proof of concept‘ study, scientists say they have successfully delivered nano-size packets of genetic code called microRNAs to treat human brain tumors implanted in mice. The contents of the super-small containers were designed to target cancer stem cells, a kind of cellular ‚seed‘ that produces countless progeny and is a relentless barrier to ridding the brain of malignant cells. (Mehr in: Cancer News — ScienceDaily)

Stem cell therapy drug may protect against smoke-related COPD symptoms

A drug used in stem cell therapy to treat certain cancers may also protect against cigarette smoke-induced lung injury. (Mehr in: Cancer News — ScienceDaily)

CAR-T immunotherapies may have a new player

Emerging CAR-T immunotherapies leverage modified versions of patient’s T-cells to target and kill cancer cells. In a new study, researchers report that similarly modified natural killer (NK) cells derived from human induced pluripotent stem cells (iPSCs) also displayed heightened activity against a mouse model of ovarian cancer. (Mehr in: Cancer News — ScienceDaily)

Fluorescent molecules reveal how cancer cells are inhibited

A team of researchers has developed a fluorescent variant of a molecule that inhibits cancer stem cells. Capturing images of when the molecule enters a cell has enabled the researchers, using cell-biological methods, to successfully describe how and where the molecule counteracts the cancer stem cells. (Mehr in: Cancer News — ScienceDaily)

Breast cancer could be prevented by targeting epigenetic proteins, study suggests

Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study suggests that inhibiting these proteins with drugs could prevent the development of breast cancer in women at high risk of the disease. (Mehr in: Cancer News — ScienceDaily)

Stem-cell niche for 10 billion colon cells a day

Researchers have discovered the identity of the stem-cell niche of the colon. The niche comprises special cells that activate the stem cells of the adjacent intestinal epithelium and are responsible for its continuous renewal. Without the activation signal, the epithelium perishes. If it’s constantly activated, early stages of cancer develop. The discovery helps to improve our understanding of intestinal cancer and inflammation. (Mehr in: Cancer News — ScienceDaily)

Cancer news

New CRISPR technique skips over portions of genes that can cause disease

16. Aug. 2018

In a new study in cells, researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. Such targeted editing could one day be useful for treating genetic diseases caused by mutations in the genome, such as Duchenne’s muscular dystrophy, Huntington’s disease or some cancers. (Mehr in: Cancer News — ScienceDaily)

- Read more

Diagnosing cancer with malaria protein: New method discovered

16. Aug. 2018

Researchers have discovered a method of diagnosing a broad range of cancers at their early stages by utilizing a particular malaria protein, which sticks to cancer cells in blood samples. The researchers hope that this method can be used in cancer screenings in the near future. (Mehr in: Cancer News — ScienceDaily)

- Read more

Retinoic acid may improve immune response against melanoma

16. Aug. 2018

Clinical trial results describe a promising strategy to remove one of melanoma’s most powerful defenses: By adding retinoic acid to standard-of-care treatment, researchers were able to turn off myeloid-derived suppressor cells (MDSCs) that turn off the immune system, leading to more immune system activity directed at melanoma. (Mehr in: Cancer News — ScienceDaily)

- Read more

Trigger, target, trigger: Scientists explore controlled carbon monoxide release

16. Aug. 2018

Scientists have developed flavonoid-based, organic carbon monoxide-releasing molecules that exhibit CO release only when triggered by visible light. Using fluorescence microscopy, the researchers demonstrate targeted CO delivery by the photoCORMs to human lung cancer cells, as well as the ability of the molecules to produce anti-inflammatory effects. (Mehr in: Cancer News — ScienceDaily)

- Read more

Childhood exposure to secondhand smoke may increase risk of adult lung disease death

16. Aug. 2018

A new study suggests that long-term exposure to secondhand smoke during childhood increases the risk of chronic obstructive pulmonary disease (COPD) death in adulthood. (Mehr in: Cancer News — ScienceDaily)

- Read more

PARP inhibitor improves progression-free survival in patients with advanced breast cancers

15. Aug. 2018

In a randomized, Phase III trial, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes. (Mehr in: Cancer News — ScienceDaily)

- Read more

New HIV therapy reduces virus, boosts immunity in drug-resistant patients

15. Aug. 2018

A new HIV drug reduced viral replication and increased immune cells in individuals with advanced, drug-resistant HIV infection. Used in combination with existing HIV medications, the drug is a promising strategy for patients who have run out of effective treatment options, the researchers said. (Mehr in: Cancer News — ScienceDaily)

- Read more

The secret behind cell revival revealed

15. Aug. 2018

Scientists identify essential genes for quiescent cells to switch back to dividing mode using fission yeast that may lead to new cancer therapies. (Mehr in: Cancer News — ScienceDaily)

- Read more

Scientists discover chemical which can kill glioblastoma cells

15. Aug. 2018

Aggressive brain tumor cells taken from patients self-destructed after being exposed to a chemical in laboratory tests, researchers have shown. (Mehr in: Cancer News — ScienceDaily)

- Read more

Light-emitting nanoparticles could provide a safer way to image living cells

15. Aug. 2018

A research team has demonstrated how light-emitting nanoparticles can be used to see deep in living tissue. Researchers hope they can be made to attach to specific components of cells to serve in an advanced imaging system that can pinpoint even single cancer cells. (Mehr in: Cancer News — ScienceDaily)

- Read more

A molecular switch may serve as new target point for cancer and diabetes therapies

15. Aug. 2018

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases. (Mehr in: Cancer News — ScienceDaily)

- Read more

Chemicals found in vegetables prevent colon cancer in mice

14. Aug. 2018

Chemicals produced by vegetables such as kale, cabbage and broccoli could help to maintain a healthy gut and prevent colon cancer, a new study shows. (Mehr in: Cancer News — ScienceDaily)

- Read more

Zombie gene protects against cancer — in elephants

14. Aug. 2018

LIF6, a dead gene that came back to life, prevents cancer by killing cells with DNA damage. (Mehr in: Cancer News — ScienceDaily)

- Read more

Potential guidance for gastric cancer treatment

14. Aug. 2018

Researchers have discovered that gastric cancer tissue samples bearing mutation of a specific gene, MUC16, too are associated with higher tumor mutation loads. Also known as tumor mutation burdens, measurement of high genetic mutation rates among cancerous versus healthy tissue has increasingly been shown to correlate with effective response rates to immunotherapy. The knowledge could bode positively for patients with the biomarker present. (Mehr in: Cancer News — ScienceDaily)

- Read more

Cancer-fighting drugs also help plants fight disease

14. Aug. 2018

Cancer-fighting drugs used on humans can help plants fight disease as well. That discovery, by plant pathologists, could help scientists develop new pathways for plants to battle infection. (Mehr in: Cancer News — ScienceDaily)

- Read more

Stress hormone is key factor in failure of immune system to prevent leukemia

14. Aug. 2018

The human stress hormone cortisol has been identified as a key factor when the immune system fails to prevent leukemia taking hold. (Mehr in: Cancer News — ScienceDaily)

- Read more

Cetuximab+RT found to be inferior to standard treatment in HPV+ oropharyngeal cancer

14. Aug. 2018

An interim analysis of data from a randomized clinical trial of patients with human papillomavirus (HPV)-positive oropharyngeal cancer found that treatment with radiation therapy and cetuximab is associated with worse overall and progression-free survival compared to the current standard treatment with radiation and cisplatin. The trial was designed to see if cetuximab with radiation would be less toxic than cisplatin with radiation without compromising survival for patients with the disease. (Mehr in: Cancer News — ScienceDaily)

- Read more

Veranstaltungen

10. TWINCORE Symposium – Frontiers in translational infection research

01. Aug. 2018

Am 31. August 2018 begrüßen wir zum 10. Mal Wissenschaftlerinnen und Wissenschaftler asu der ganzen Welt zum TWINCORE Symposium. Internationale Experten führen durch aktuelle Entwicklungen der translationalen Infektionsforschung.

http://www.twincore.de/twincore/

Nähere Informationen folgen… (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

OSTSEETAG

01. Aug. 2018

Wer Ostsee-Expertenwissen braucht, ist hier richtig: 3. Ostseetag im Stadthafen Rostock! (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

Klinische Bewertung medizinischer Software

01. Aug. 2018

Für jedes Medizinprodukt muss der Hersteller anhand klinischer Daten die Eignung für die vorgesehene Verwendung nachweisen und die klinischen Risiken vor dem Hintergrund des zu erwartenden Nutzens für den Patienten bewerten. Dies ist ein kontinuierlicher Prozess, der sich bis zur klinischen Nachbeobachtung nach dem Inverkehrbringen erstreckt. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

„Blue Biotechnology in the Baltic Sea Region – from Science to Business“

01. Aug. 2018

Es ist uns eine große Freude, Sie zu der internationalen Konferenz „Blue Biotechnology in the Baltic Sea Region – from Science to Business“ einzuladen. Rund 100 Wissenschaftler, Unternehmer und Interessenvertreter aus dem Umfeld der marinen Biotechnologie werden vom 22. bis zum 24. August 2018 neueste Resultate aus Forschung und Entwicklung sowie erfolgreiche ökonomische Umsetzungen präsentieren. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

12th International Conference and Workshop on Biological Barriers

01. Aug. 2018

Biological Barriers is an international scientific event , organized every two years and receiving constantly 200+ registered attendees from all over the world. In the focus of BioBarriers are human cell and tissue models for facilitating clinical translation of new drugs and delivery systems, especially in the context of infectious diseases. Moreover, we will discuss innovative concepts and materials, also capable to overcome non-cellular diffusion barriers such as mucus or bacterial biofilms. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

RVZ Kolloquium: Prof. Michael Rape

01. Jul. 2018

Prof. Michael Rape from UC Berkeley (US) will talk about his research „The other code: roles of ubiquitin in neuronal development and neurodegeneration“ at the Rudolf Virchow Center of the University of Würzburg. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

Quantum Technology – Impact on Computing and Communication

01. Jul. 2018

Quantum technology forms the technological basis for the development of quantum computers, quantum sensors, quantum cryptography, and quantum communication systems. These technologies have the potential to disrupt a variety of existing industries. For example, quantum computers promise new possibilities for solving computing-intensive or previously not efficiently solvable problems. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen