Skin cancer rates in England far higher than previously thought, according to new database

Data from a newly established UK skin cancer database, the largest of its kind in the world, has revealed that there are over 45,000 cutaneous squamous cell carcinomas every year in England, 350 percent more than previous estimates suggested. (Mehr in: Cancer News — ScienceDaily)

CRISPR screen reveals new targets in more than half of all squamous cell carcinomas

Researchers sheds light on p63 activity in squamous cell carcinoma of the lung, providing an actionable path forward to drug development against this known cause of cancer. (Mehr in: Cancer News — ScienceDaily)

Study links widely-used drug azathioprine to skin cancers

A drug used to treat inflammatory bowel disease, arthritis and vasculitis as well as to prevent organ rejection in transplant patients has been identified as an important contributor to skin cancer development. The research identified a `strong case for an association‘ between the drug azathioprine and the mutational signature found in cases of cutaneous squamous cell carcinoma (cSCC), a common form of skin cancer. (Mehr in: Cancer News — ScienceDaily)

In clinical trial, cream reduces squamous cell carcinoma risk

Results of a new randomized, double-blinded, controlled clinical trial in veterans showed a 75 percent reduction in the risk of needing surgery to treat a squamous cell carcinoma for a year after applying a skin cream for up to four weeks. (Mehr in: Cancer News — ScienceDaily)

Gaining insight into the molecular mechanisms behind squamous cell cancer

Researchers report a new molecular mechanisms regulating cellular fate of squamous cell carcinomas. (Mehr in: Cancer News — ScienceDaily)

Frequent sun exposure may cue gene fusion found in skin cancer

Researchers have determined that a particular fusion gene has a tendency to be found in cutaneous squamous cell carcinoma (cSCC) lesions on skin exposed frequently to the sun. The fusion gene is unique to cSCC and appears to be related to frequent sun exposure. It is believed that the work will open doors to a new form of personalized cSCC treatment. (Mehr in: Cancer News — ScienceDaily)

Newly developed nomograms provide accurate predictions for patients with oropharyngeal cancer

Researchers recently developed and validated a nomogram that can predict 2-year and 5-year overall survival (OS) and progression-free survival (PFS) for patients with local-regionally advanced oropharyngeal squamous cell carcinoma (OPSCC) treated primarily with radiation-based therapy. (Mehr in: Cancer News — ScienceDaily)

Hope for better lung cancer treatment on horizon

There is a better way to recruit the right participants for promising new anti-cancer drugs called FGFR (fibroblast growth factor receptor) inhibitors, which are being investigated for treating lung squamous cell carcinoma, outlines a new report. (Mehr in: Cancer News — ScienceDaily)

Skin cancer on the rise

New diagnoses for two types of skin cancer increased in recent years, according to a team of researchers. Their paper uses medical records from the Rochester Epidemiology Project to compare diagnoses of basal cell carcinoma and squamous cell carcinoma ? both nonmelanoma skin cancers ? between 2000 and 2010 to diagnoses in prior years. (Mehr in: Cancer News — ScienceDaily)

Targeting cancer stem cells improves treatment effectiveness, prevents metastasis

Targeting cancer stem cells may be a more effective way to overcome cancer resistance and prevent the spread of squamous cell carcinoma — the most common head and neck cancer and the second-most common skin cancer, according to a new study. Head and neck squamous cell carcinoma is a highly invasive form of cancer and frequently spreads to the cervical lymph nodes. (Mehr in: Cancer News — ScienceDaily)

Roadmap to more personalized cancer treatment

People with advanced head and neck squamous cell carcinoma and the KRAS-variant inherited genetic mutation have significantly improved survival when given a short course of the drug cetuximab in combination with standard chemotherapy and radiation, research has found. (Mehr in: Cancer News — ScienceDaily)

Researchers find association between oral bacteria and esophageal cancer

Researchers have found a bacterial species responsible for gum disease, Porphyromonas gingivalis, is present in 61 percent of patients with esophageal squamous cell carcinoma. (Mehr in: Cancer News — ScienceDaily)

Study examines associations of HPV types, risk of head and neck cancer

A new study suggests detection of human papillomavirus (HPV)-16 in the oral cavity was associated with 22-times increased risk of oropharyngeal squamous cell carcinoma. (Mehr in: Cancer News — ScienceDaily)

Radiotherapeutic bandage shows potential as treatment for skin cancer

A radiotherapeutic bandage is being evaluated by researchers for efficacy against squamous cell carcinoma (SCC) in an animal model. These results could confirm the viability of a new and improved strategy for the radiotherapeutic treatment of skin cancer in the clinic. (Mehr in: Cancer News — ScienceDaily)

Skin squamous cell carcinoma

Researchers have uncovered new genetic alterations involved in the development of skin squamous cell carcinoma. (Mehr in: Cancer News — ScienceDaily)

Erythropoietin combined with radiation therapy does not improve local-regional control in anemic patients with head and neck cancer

Long-term analysis of Radiation Therapy Oncology Group 9903 demonstrates that the addition of erythropoietin did not improve local-regional control for anemic patients with head and neck squamous cell carcinoma who receive radiation therapy or chemoradiation, according to a study. (Mehr in: Cancer News — ScienceDaily)

Potential prognostic marker for recurrence of head and neck squamous cell carcinoma

The first evidence that the mediator complex subunit 15 (MED15) may play a crucial role in the pathophysiology of head and neck squamous cell carcinoma (HNSCC) has been discovered by researchers. MED15 overexpression was found to be associated with higher mortality rates in HNSCC patients with cancer recurrence, particularly in oral cavity/oropharyngeal tumors, according to the study. (Mehr in: Cancer News — ScienceDaily)

A global assessment of cancer genomic alterations in epigenetic mechanisms

Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira

Abstract

Background

The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients.

Results

Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover a general trend in which transcriptional profiles and somatic mutations in tumor samples favor increased transcriptionally repressive histone methylation, and defective chromatin remodeling.

Conclusions

This unbiased approach confirms previously published data, uncovers novel cancer-associated aberrations targeting epigenetic mechanisms, and justifies continued monitoring of chromatin-related alterations as a class, as more cancer types and distinct cancer stages are represented in cancer genomics data repositories.

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