Tongue microbiome could help identify patients with early-stage pancreatic cancer

Differences in the abundance of certain bacteria living on the tongue can distinguish patients with early pancreatic cancers from healthy individuals, according to results from a new study.

Quelle: Sciencedaily

Effective method for reducing hospital stay after ‚whipple‘ operation

Implementing a new recovery pathway speeds time to next treatment for pancreatic cancer patients by 15 days, without increasing complication rates.

Quelle: Sciencedaily

Vine Compound Starves Cancer Cells

Researchers from Würzburg and Toyama have discovered that a compound isolated from tropical rainforest vines inhibits the growth of pancreatic cancer cells in the lab. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Rainforest vine compound starves pancreatic cancer cells

Pancreatic cancer cells are known for their ability to thrive under extreme conditions of low nutrients and oxygen, a trait known in the cancer field as ‚austerity.‘ The cells‘ remarkable resistance to starvation is one reason why pancreatic cancer is so deadly. Now researchers have identified a compound from a Congolese plant that has strong “antiausterity“ potential, making pancreatic cancer cells susceptible to nutrient starvation. (Mehr in: Cancer News — ScienceDaily)

Weight during adolescence may affect pancreatic cancer risk in adulthood

New research has linked adolescent obesity with up to a four-fold increased risk of pancreatic cancer later in life. The study’s results also suggest that overweight and even higher weight within the ’normal‘ weight range in men may increase pancreatic cancer risk in a graded manner. (Mehr in: Cancer News — ScienceDaily)

Turning cells against pancreatic cancer

Pancreatic cancer is infamously resistant to treatment options because the tumor is often surrounded by cells which are “tricked“ into protecting it. Now, researchers have identified the special signals that encourage some of these cells to either help the cancer, or–ideally–hinder it. (Mehr in: Cancer News — ScienceDaily)

Why some cancers affect only young women

Among several forms of pancreatic cancer, one of them affects specifically women, often young, even though the pancreas is an organ with little exposure to sex hormones. This pancreatic cancer, known as ‚mucinous cyst,‘ has strange similarities with another mucinous cancer, affecting the ovaries. By conducting large-scale analyses of genomic data, researchers have provided an answer: both tumors originate from embryonic germ cells. (Mehr in: Cancer News — ScienceDaily)

New drug blocks pancreatic cancer growth in mice, study finds

A newly developed drug can prevent the most common type of pancreatic cancer from growing and spreading in laboratory mice, according to a new study. The study also demonstrated in mice that the drug, Metavert, may prevent patients from developing a resistance to currently used pancreatic cancer chemotherapies. (Mehr in: Cancer News — ScienceDaily)

Eight of 10 people with cancer risk genes don’t know it

Genomic screening shows that more than 80 percent of those who carry an identifiable genetic risk for breast, ovarian, prostate, and pancreatic cancer don’t know it. (Mehr in: Cancer News — ScienceDaily)

New blood test detects early stage pancreatic cancer

Pancreatic cancer is currently very difficult to detect while it is still resectable. A new blood test can detect pancreatic cancer in the very earliest stages of the disease. (Mehr in: Cancer News — ScienceDaily)

Blocking digestive hormone may prevent diet-induced pancreatic cancer

A high-fat diet may promote the growth of pancreatic cancer independent of obesity because of the interaction between dietary fat and cholecystokinin (CCK), a digestive hormone. In addition, blocking CCK may help prevent the spread of pancreatic tumors to other areas of the body (metastases). (Mehr in: Cancer News — ScienceDaily)

Pancreatic cancer: Mutable cancer cells are more dangerous

Pancreatic cancer often spreads, forming metastases in the liver or lungs. The prognosis is better for patients with metastases in the lungs. However, the organ that is more likely to be affected depends on the cancer cells’ ability to alter their characteristics and shape – as a research team at the Technical University of Munich (TUM) has discovered. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

How pancreatic tumors lead to weight loss

A study offers insight into the weight loss seen in pancreatic cancer patients, and suggests that weight loss may not necessarily affect patients‘ survival. (Mehr in: Cancer News — ScienceDaily)

New drugs could also be deployed against lung and pancreatic cancers

A new anti-cancer drug may be effective against a wider range of cancers than previously thought. Using a mouse model and samples taken from cancer patients, a team from the Technical University of Munich (TUM) has shown that a new class of drugs known as SHP2 inhibitors is also effective against aggressive, hard-to-treat tumors such as lung and pancreatic cancers. Clinical trials currently underway had previously excluded patients with these cancers. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

A way to prevent pancreatic cancer from spreading post-surgery?

New research suggests a strategy for lowering the odds of metastasis following successful pancreatic cancer surgery: The post-operative period, suggests a researcher, ‚offers a window during which efforts might be made to keep cortisol levels down and T cells strong so the patient’s own immune system can kill the cancer cells that have made their way to other parts of the body but until this point have been dormant.‘ (Mehr in: Cancer News — ScienceDaily)

Novel theranostic approach for treating pancreatic cancer patients shows promise

German researchers have developed a novel diagnostic and therapeutic (theranostic) procedure for patients with ductal pancreatic adenocarcinoma, a deadly cancer with an extremely poor prognosis (five-year survival rate of less than 5 percent) and limited treatment options. (Mehr in: Cancer News — ScienceDaily)

Injecting gene cocktail into mouse pancreas leads to human-like tumors

A researcher has invented a unique method to generate, in mice, pancreatic tumors that resemble human pancreatic cancer. This will be a tool researchers can use to develop new drugs that extend patients‘ lives, and it is a tool researchers have not had at their disposal before. (Mehr in: Cancer News — ScienceDaily)

The connection between diet, obesity, and cancer: Nutrition experts explore the evidence

About one third of cancer cases are estimated to be linked to dietary and other modifiable risk factors, especially for obesity-related cancers such as breast, colorectal, ovarian, endometrial, kidney, gallbladder, esophageal, and pancreatic cancers. (Mehr in: Cancer News — ScienceDaily)

Gut bacteria determine speed of tumor growth in pancreatic cancer

The population of bacteria in the pancreas increases more than a thousand fold in patients with pancreatic cancer, and becomes dominated by species that prevent the immune system from attacking tumor cells. (Mehr in: Cancer News — ScienceDaily)

Improved method of treating pancreatic cancer

A heating and freezing process known as dual thermal ablation can kill pancreatic cancer cells, according to new research. (Mehr in: Cancer News — ScienceDaily)

Researchers discover a potential new therapeutic strategy for pancreatic cancer

In most pancreatic cancer patients, the diagnosis is made when the disease is already advanced, and there is no effective treatment at present. There have been no significant advances to combat it in recent decades and unfortunately, its occurrence is on the increase. Now, a group of researchers may have found a new form of attack. (Mehr in: Cancer News — ScienceDaily)

Pancreatic cancer: Gene duplication explains tumor aggressiveness

Pancreatic cancer is a form of cancer associated with the highest mortality rates in the world. Genetic changes that could explain his aggressiveness and early metastasis had not been found yet. A team has now shown that those characteristics can be explained by specific gene amplifications which occur along various evolutionary pathways of the cancer. Based on this discovery, they have derived basic principles underlying the biology of pancreatic cancer. (Mehr in: Cancer News — ScienceDaily)

Oral health may have an important role in cancer prevention

The bacteria that cause periodontitis, a disease affecting the tissues surrounding the teeth, seems to play a part also in the onset of pancreatic cancer. (Mehr in: Cancer News — ScienceDaily)

Novel nanomedicine inhibits progression of pancreatic cancer in mice

A new study pinpoints the inverse correlation between a known oncogene — a gene that promotes the development of cancer — and the expression of an oncosuppressor microRNA as the reason for extended pancreatic cancer survival. The study may serve as a basis for the development of an effective cocktail of drugs for this deadly disease and other cancers. (Mehr in: Cancer News — ScienceDaily)

Targeted treatment could prevent spread of pancreatic cancer, heart damage

A new targeted treatment could benefit patients with certain pancreatic tumors by preventing spread of the cancer and protecting their heart from damage — a direct result of the tumor. Higher levels of serotonin among other tumor secretions can cause injury to the valves of the heart over time, leading to cardiac impairment — a condition referred to as cardiac carcinoid disease — in these patients. (Mehr in: Cancer News — ScienceDaily)