Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Bei aggressivem Blutkrebs mit Mutationen in STAT5 wirken etablierte Krebstherapeutika

Herausragende Publikation des Ludwig Boltzmann Institut für Krebsforschung: Die Publikation beschreibt, dass eine häufig auftretende mutierte Form des transkriptionellen Aktivators STAT5B krebsfördernde Gene durch die direkte Bindung an DNA einschaltet. Überraschend ist, dass Krebszellen trotz der Mutation weiterhin Zytokine und Wachstumsfaktoren benötigen. Zielgerichtete Medikamente gegen Zytokinsignale zeigten im neu etablierten Tiermodell starke Wirkung. Dies kann eine wichtige Entdeckung für die Behandlung von aggressiven Lymphomen sein, die häufig starke Aktivierung von STAT5 aufweisen. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Revolutionary imaging technique uses CRISPR to map DNA mutations

A new nanomapping technology could transform the way disease-causing genetic mutations are diagnosed and discovered. (Mehr in: Cancer News — ScienceDaily)

Key to unlock blocked differentiation in microRNA-deficient embryonic stem cells

Scientists have partly solved a long-unanswered basic question about stem cells — why are pluripotent stem cells that have mutations to block the production of microRNAs unable to differentiate? (Mehr in: Cancer News — ScienceDaily)

Dresdner Wissenschaftler entwickeln einen Sensor für das wichtigste Krebs-Gen

Molekularer „Detektor“ erkennt häufigste Krebs-Mutation in Zellen und leitet deren Abtöten ein (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Jahrestagung DGHO 2017: Beginnt mit Venetoclax ein neues Zeitalter in der Therapie der CLL?

Wiesbaden, 2. November 2017 – Ein Paradigmenwechsel in der Behandlung von chronischer lymphatischer Leukämie (CLL): Das kündigte sich während des Vortrages von Professor Wolfgang Knauf, Frankfurt, während des AbbVie Symposiums an. Denn mit Venetoclax, dem oralen Inhibitor des B-Zell-Lymphom-2-Proteins (BCL-2), kann ein tiefes Ansprechen auch bei Patienten erreicht werden, bei denen es nach Chemoimmuntherapie und einer Therapie mit Inhibitoren des B‐Zell‐Rezeptor‐Signalwegs (BCRi) zum Progress kommt.(1) Ebenso zeigen vorbehandelte CLL-Patienten mit 17p-Deletion und/oder TP53-Mutation, bei denen BCRi versagten, ein gutes Ansprechen.(1,2) (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

PARP inhibitor may be effective against some TNBC lacking BRCA mutations

The investigational PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) that had BRCA mutations and also those that did not have BRCA mutations but had other alterations in DNA damage-repair pathways. (Mehr in: Cancer News — ScienceDaily)

Mutation in fallopian tube lesions may help catch ovarian cancer years earlier

Screening for tumor cells in the fallopian tubes of women at high-risk for ovarian cancer may help detect the cancer years before it develops further, suggests a new study. The work traces the origins of high-grade serous ovarian carcinoma, the most frequent type of ovarian cancer that is often diagnosed at advanced stages, back to fallopian tube lesions known as ‚p53 signatures‘ and serous tubal intraepithelial carcinomas (STICs) that harbor the TP53 gene mutations. (Mehr in: Cancer News — ScienceDaily)

Study links mutations in notch gene to role in B cell cancers

In B cell tumors, mutated overactive versions of the Notch protein directly drive the expression of the Myc gene and many other genes that participate in B cell signaling pathways, researchers have found. Myc is a critical gene in governing cell proliferation and survival. (Mehr in: Cancer News — ScienceDaily)

One to 10 mutations are needed to drive cancer, scientists find

For the first time, scientists have provided unbiased estimates of the number of mutations needed for cancers to develop, in a study of more than 7,500 tumors across 29 cancer types. Researchers have adapted a technique from the field of evolution to confirm that, on average, one to ten driver mutations are needed for cancer to emerge. (Mehr in: Cancer News — ScienceDaily)

Yeast spotlights genetic variation’s link to drug resistance

Researchers have shown that genetic diversity plays a key role in enabling drug resistance to evolve. Scientists show that high genetic diversity can prime new mutations that cause drug resistance. The study has implications for our understanding of the evolution of resistance to antimicrobial and anticancer drugs. (Mehr in: Cancer News — ScienceDaily)

Cancer news

Deadly heart rhythm halted by noninvasive radiation therapy

14. Dez. 2017

Radiation therapy often is used to treat cancer patients. Now, doctors have shown that radiation therapy — aimed directly at the heart — can be used to treat patients with a life-threatening heart rhythm. They treated five patients with irregular heart rhythms, called ventricular tachycardia, who had not responded to standard treatments. The therapy resulted in a dramatic reduction in the number of ventricular tachycardia episodes. (Mehr in: Cancer News — ScienceDaily)

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CT scans of Egyptian mummies reveal oldest known cases of breast cancer and multiple myeloma

14. Dez. 2017

An international team has discovered the world’s oldest known cases of breast cancer and multiple myeloma (a type of bone marrow cancer). The discoveries were made by conducting CT scans of two mummies found in the pharaonic necropolis of Qubbet el-Hawa in Aswan, Egypt. (Mehr in: Cancer News — ScienceDaily)

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Frequent sun exposure may cue gene fusion found in skin cancer

14. Dez. 2017

Researchers have determined that a particular fusion gene has a tendency to be found in cutaneous squamous cell carcinoma (cSCC) lesions on skin exposed frequently to the sun. The fusion gene is unique to cSCC and appears to be related to frequent sun exposure. It is believed that the work will open doors to a new form of personalized cSCC treatment. (Mehr in: Cancer News — ScienceDaily)

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What keeps stem cells in their undifferentiated state?

13. Dez. 2017

A special cluster of proteins helps unwind DNA during cell division and plays a key role in keeping stem cells in their immature state, scientists have discovered. This study also points to a better understanding of how cancer cells manage to sustain rapid cell division without triggering cell death. (Mehr in: Cancer News — ScienceDaily)

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A metallopeptide targets and disrupts mitochondrial function in breast cancer stem cells

13. Dez. 2017

Killing malignant mitochondria is one of the most promising approaches in the development of new anticancer drugs. Scientists have now synthesized a copper-containing peptide that is readily taken up by mitochondria in breast cancer stem cells, where it effectively induces apoptosis. The study also highlights the powerful therapeutic potential of the metallopeptides. (Mehr in: Cancer News — ScienceDaily)

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Male virgins can still acquire HPV, study finds

13. Dez. 2017

Men who have never engaged in sexual intercourse are still at risk for acquiring HPV, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Scientists develop new artificial ovary prototype

13. Dez. 2017

Researchers have taken important steps towards creating transplantable artificial ovaries. Once successful, these could be of value to women struggling with infertility or cancer patients who cannot conceive after undergoing radiation or chemotherapy. The research team has identified a protein formulation that closely resembles the structure and rigidity of the natural tissue lining a woman’s ovaries. (Mehr in: Cancer News — ScienceDaily)

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Important new aspects are revealed about the control of cell division

12. Dez. 2017

Experts have published a new study on the mechanisms that regulate cell division and guarantee the correct distribution of chromosomes during this process. In particular, they especially highlight the fundamental role that an organelle, specifically the nucleolus, plays in the coordination of these processes. (Mehr in: Cancer News — ScienceDaily)

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Closing in on advanced prostate cancer

12. Dez. 2017

Medical researchers have discovered a new avenue through which to attack prostrate cancer cells that have developed drug-resistance. (Mehr in: Cancer News — ScienceDaily)

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Simple test can diagnose two cancer types

12. Dez. 2017

A blood test using infrared spectroscopy can be used to diagnose two types of cancer, lymphoma and melanoma, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Cancer imaging aid developed from horse chestnuts

12. Dez. 2017

Cancer imaging can be simplified by a photonic process utilizing molecules derived from horse chestnuts, research shows. (Mehr in: Cancer News — ScienceDaily)

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Cancer-protecting enzyme is ‚also promoting its growth‘

12. Dez. 2017

The NEIL3 enzyme has long been known to repair ‘day-to-day’ oxidative damage to DNA that is implicated in diseases of ageing, including dementia and cancer. (Mehr in: Cancer News — ScienceDaily)

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Faster, more accurate cancer detection using nanoparticles

12. Dez. 2017

Using light-emitting nanoparticles, scientists have invented a highly effective method to detect tiny tumors and track their spread, potentially leading to earlier cancer detection and more precise treatment. The technology could improve patient cure rates and survival times. (Mehr in: Cancer News — ScienceDaily)

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Enhancing chemotherapy’s efficiency against leukemia

12. Dez. 2017

Researchers have found a mechanism through which certain types of leukemia resist chemotherapy, revealing novel molecular targets to improve this therapy’s efficiency. (Mehr in: Cancer News — ScienceDaily)

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Medical marijuana for children with cancer? What providers think

12. Dez. 2017

Most providers willing to consider medical marijuana use in children with cancer, but those with legal eligibility to certify are less likely to approve. (Mehr in: Cancer News — ScienceDaily)

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Drug suppresses spread of breast cancer caused by stem-like cells

12. Dez. 2017

Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report researchers. (Mehr in: Cancer News — ScienceDaily)

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Turning pathogens against each other to prevent drug resistance

11. Dez. 2017

Limiting a much-needed resource could pit pathogens against one another and prevent the emergence of drug resistance. New research demonstrates that harnessing competition among pathogens inside a patient could extend the life of existing drugs where resistance is already present and prevent resistance to new drugs from emerging. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

12. Jahrestagung der Deutschen Wirbelsäulengesellschaft (DWG)

20. Nov. 2017

Der diesjährige Schwerpunkt des Kongresses liegt auf den Themen Trauma und Tumor in der Wirbelsäulenchirurgie. Wichtige wissenschaftliche Beiträge zu Tumorerkrankungen, degenerativen Erkrankungen, entzündlichen und metabolischen Erkrankungen, Verletzungen und Deformitäten aber auch zu innovativen Techniken erwarten die Besucherinnen und Besucher. Dabei steht ein fächerübergreifender Ansatz im Vordergrund, denn auch auf dem Gebiet der Wirbelsäulenheilkunde gilt es, Bewährtes zu erhalten und gleichzeitig neuen Behandlungsmethoden gegenüber offen zu sein. Dass die Deutsche Wirbelsäulengesellschaft diesen Anspruch ernst nimmt, zeigt auch die Zentren-Zertifizierung, die in diesem Jahr gestartet wurde. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Biologisierung der Medizintechnik – Workshop VII – Biomaterial – Immunsystem Wechselwirkungen

01. Nov. 2017

Wechselwirkungen zwischen Biomaterialien und dem Organismus können zu Problemen führen oder Chancen eröffnen. Die Einflüsse reichen vom Biofouling während des Erstkontaktes bis hin zu Implantatverlusten. Eine zentrale Rolle spielt das Immunsystem, das viele dieser Reaktionen koordiniert. Ziel ist es deshalb, ein rationales Design von Biomaterialien mit immunmodulierenden Eigenschaften zu erreichen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Akademievorlesung "Willkommen in Utopia." | 16.11.2017 18:00 Uhr – 20:00 Uhr

01. Nov. 2017

Mit der Akademievorlesung zieht die Interdisziplinare Arbeitsgruppe „Gentechnologiebericht“ 16 Jahre nach ihrer Gründung Bilanz anlässlich eines heute wie damals höchst umstrittenen und viel diskutierten Forschungsbereichs. In Expertenbeiträgen und Podiumsdiskussionen werden die Gentechnologien dabei sowohl in ihrer historischen und zukünftigen Entwicklung als auch in ihrer aktuellen gesellschafts- und forschungspolitischen Relevanz eingeordnet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Akademievorlesung "Wie werden Gentechnologien kontrolliert?" | 09.11.2017 18:00 Uhr – 21:00 Uhr

01. Nov. 2017

Mit der Akademievorlesung zieht die Interdisziplinare Arbeitsgruppe „Gentechnologiebericht“ 16 Jahre nach ihrer Gründung Bilanz anlässlich eines heute wie damals höchst umstrittenen und viel diskutierten Forschungsbereichs. In Expertenbeiträgen und Podiumsdiskussionen werden die Gentechnologien dabei sowohl in ihrer historischen und zukünftigen Entwicklung als auch in ihrer aktuellen gesellschafts- und forschungspolitischen Relevanz eingeordnet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Akademievorlesung "Gentechnologien damals, heute und morgen" | 02.11.2017 18:00 Uhr – 21:00 Uhr

01. Nov. 2017

Mit der Akademievorlesung zieht die Interdisziplinare Arbeitsgruppe „Gentechnologiebericht“ 16 Jahre nach ihrer Gründung Bilanz anlässlich eines heute wie damals höchst umstrittenen und viel diskutierten Forschungsbereichs. In Expertenbeiträgen und Podiumsdiskussionen werden die Gentechnologien dabei sowohl in ihrer historischen und zukünftigen Entwicklung als auch in ihrer aktuellen gesellschafts- und forschungspolitischen Relevanz eingeordnet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Air Pollution and Health: New Research Perspectives for a Growing Global Crisis

01. Nov. 2017

Joint symposium by the Academy of Science of South Africa and the Leopoldina (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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6. Morbi-RSA Symposium

01. Nov. 2017

Eigentlich soll der morbiditätsorientierte Risikostrukturausgleich – kurz: Morbi-RSA – den Finanzausgleich zwischen den gesetzlichen Krankenversicherungen regeln. Fakt ist: Die Kassen haben nach wie vor die Möglichkeit, ärztliche Diagnosen zu beeinflussen, um so höhere Zuwendungen aus dem Gesundheitsfonds zu erreichen. Das geht aus einem Gutachten des Berliner IGES Instituts hervor – und liefert jede Menge Zündstoff für das 6. Morbi-RSA Symposium am 20. November 2017 in Essen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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