Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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More insights into healthy aging mechanisms from the roundworm

What mechanisms ensure healthy aging? Researchers from IUF and HHU in Düsseldorf investigate this in the roundworm, an established organism for aging research. A study which was recently published in EMBO Reports provides new insights into the mechanisms of longevity promoted by reduced mitochondrial activity. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Channels for the Supply of Energy

Freiburg scientists elucidate the mechanism for the transport of water-insoluble protein molecules in mitochondria (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

A 150-year-old drug might improve radiation therapy for cancer

A drug first identified 150 years ago and used as a smooth-muscle relaxant might make tumors more sensitive to radiation therapy. Researchers found that the drug papaverine inhibits the respiration of mitochondria, the oxygen-consuming and energy-making components of cells, and sensitizes model tumors to radiation. They found that the drug does not affect the radiation sensitivity of well-oxygenated normal tissues. (Mehr in: Cancer News — ScienceDaily)

Chemotherapy may lead to mitochondrial dysfunction in skeletal muscle

Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction, according to new research. Dysfunctional mitochondria, the energy centers of the cells, may contribute to fatigue and weakness that some people with breast cancer experience through the course of disease treatment. (Mehr in: Cancer News — ScienceDaily)

Proof of Concept: Gene therapy for mitochondrial diseases

Mitochondrial disease is now thought to be the second most commonly diagnosed genetic disease worldwide, and, unfortunately, there are still no proven treatment strategies for those diagnosed. Scientists from the Max Planck Institute for Biology of Ageing in Cologne were involved in collaborations to apply gene-therapy approaches in mice to successfully treat an animal model of mitochondrial disease. This may pave the way for future therapeutic strategies for patients. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Proof of Concept: Gentherapie bei mitochondrialen Erkrankungen

Mitochondriale Erkrankungen zählen heute zu den zweithäufigsten diagnostizierten genetischen Erkrankungen weltweit, und leider gibt es immer noch keine bewährten Behandlungsstrategien. Wissenschaftler des Max-Planck-Instituts für Biologie des Alterns in Köln haben nun in einer Kooperationsarbeit einen Gentherapieansatz an Mäusen angewandt, der zu einer erfolgreichen Behandlung der Mitochondrienerkrankung in diesen Tieren führte. Damit wurde der Weg für zukünftige therapeutische Strategien am Menschen geebnet. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

„Science“-Study: Proteins surf to mitochondria – Novel transport pathway discovered

Proteins are essential constituents of cells and their compartments. Prof. Johannes Herrmann, a researcher at the Technische Universität Kaiserslautern, and his team discovered a novel mechanism by which newly synthesized proteins reach their respective target compartment in the cell. Proteins destined to mitochondria, the cell’s powerhouse, are not directly transported to mitochondria but are directed to the surface of the endoplasmic reticulum, where they “surf” along its surface. As shown in the renowned journal “Science”, this so far unknown mechanism keeps newly synthesized protein transport-competent and might prevent their aggregation. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

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Potential indicator for the early detection of dementias

Researchers at the University of Basel have discovered a factor that could support the early detection of neurodegenerative diseases such as Alzheimer’s or Parkinson’s. This cytokine is induced by cellular stress reactions after disturbances of the mitochondria, the “cell’s power plants,“ as neuropathologists write in the journal Cell Reports. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Scientists discover potential therapy for human copper metabolism disorders

Individuals with defects in copper metabolism may soon have more targeted treatment options thanks to a new discovery. A new report that an investigational anticancer-drug, elesclomol, can restore the production of cytochrome oxidase protein complex, a critical copper-dependent enzyme required for mitochondrial energy production. (Mehr in: Cancer News — ScienceDaily)

Proteins with different evolutionary histories now do the same job

University of Tübingen researchers discover convergent evolution in mitochondria in fungi and single-celled parasites (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Cancer news

Genetic marker, predictor of early relapse in pediatric ALL uncovered

14. Dez. 2018

Researchers recently discovered that by testing the level of NER (nucleotide excision repair) gene expression, pediatric oncologists can determine the likelihood of early relapse (less than three years) in their acute lymphoblastic leukemia (ALL) patients. (Mehr in: Cancer News — ScienceDaily)

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Exercise-induced hormone irisin triggers bone remodeling in mice

13. Dez. 2018

Exercise has been touted to build bone mass, but exactly how it actually accomplishes this is a matter of debate. Now, researchers show that an exercise-induced hormone activates cells that are critical for bone remodeling in mice. A study identifies a receptor for irisin, an exercise hormone, and shows that irisin impacts sclerostin in mice, a major cellular regulator of bone structure in humans. (Mehr in: Cancer News — ScienceDaily)

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Drug targets for Ebola, Dengue, and Zika viruses found in lab study

13. Dez. 2018

No drugs are currently available to treat Ebola, Dengue, or Zika viruses, which infect millions of people every year and result in severe illness, birth defects, and even death. Scientists may finally change that. They identified key ways the three viruses hijack the body’s cells, and they found at least one potential drug that can disrupt this process in human cells. (Mehr in: Cancer News — ScienceDaily)

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Excess body weight responsible for nearly 4 percent of cancers worldwide

13. Dez. 2018

Excess body weight accounted for approximately 3.9 percent of all cancers worldwide in 2012, a figure that is expected to rise in the coming decades given current trends. (Mehr in: Cancer News — ScienceDaily)

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Unlocking the secrets of how cells communicate offers insights into treating diseases

12. Dez. 2018

Researchers have made a significant breakthrough by developing the 3D structure of proteins from inside the eye lens that control how cells communicate with each other, which could open the door to treating diseases such as cataracts, stroke and cancer. (Mehr in: Cancer News — ScienceDaily)

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Improved understanding of the pathology of dwarfism may lead to new treatment targets

12. Dez. 2018

Pseudoachondroplasia (PSACH) is a severe inherited dwarfing condition In PSACH, a genetic mutation leads to abnormal retention of cartilage oligomeric matrix protein (COMP) within the endoplasmic reticulum (ER) of cartilage-producing cells (chondrocytes), which interferes with function and cell viability. Investigators describe how this protein accumulation results in ‚ER stress‘ and initiates a host of pathologic changes. These findings may open up new ways to treat PSACH and other ER-stress-related conditions. (Mehr in: Cancer News — ScienceDaily)

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Faster, cheaper test can help predict risk of metastasis in prostate cancer patients

12. Dez. 2018

A report describes a new assay to assess copy number alterations that is cheaper, faster, reproducible, and requires less tissue than other diagnostic techniques and has the potential to significantly enhance prostate cancer evaluation. (Mehr in: Cancer News — ScienceDaily)

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Novel technique may significantly reduce breast biopsies

12. Dez. 2018

A novel technique that uses mammography to determine the biological tissue composition of a tumor could help reduce unnecessary breast biopsies, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Disruption of circadian rhythm as risk factor for diseases

11. Dez. 2018

Scientists report a time-keeping mechanism in liver cells that helps sustain key organ tasks can contribute to diseases when its natural rhythm is disrupted. (Mehr in: Cancer News — ScienceDaily)

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Shape-shifting cell breakthrough

11. Dez. 2018

A new computational model gives a clearer picture of the structure and mechanics of soft, shape-changing cells that could provide a better understanding of cancerous tumor growth, wound healing, and embryonic development. (Mehr in: Cancer News — ScienceDaily)

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Lethal combination: Drug cocktail turns off the juice to cancer cells

11. Dez. 2018

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers two years ago. In a follow-up study, scientists report that this drug cocktail induces cancer cell death by switching off their energy supply. (Mehr in: Cancer News — ScienceDaily)

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Taking uncertainty out of cancer prognosis

11. Dez. 2018

An analysis of nearly 20,000 cancer patient histories and genetic data has revealed that knowing the genetic cause of a cancer does not help predict how deadly the disease will be. Instead, researchers have discovered that copy number variations in specific gene sites are far more informative, providing new opportunities to improve prognosis. (Mehr in: Cancer News — ScienceDaily)

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New light-based technology reveals how cells communicate in human disease

11. Dez. 2018

Scientists have developed a new technique that uses light to understand how cells communicate in human disease. (Mehr in: Cancer News — ScienceDaily)

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Pushing closer to a new cancer-fighting strategy

11. Dez. 2018

A molecular pathway that’s frequently mutated in many different forms of cancer becomes active when cells push parts of their membranes outward into bulging protrusions, researchers report. (Mehr in: Cancer News — ScienceDaily)

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Increased risk for breast cancer after childbirth may last more than 20 years

10. Dez. 2018

The increased risk for breast cancer that occurs after childbirth can last more than 20 years. The risk may be enhanced when a woman is older at first birth or has a family history of breast cancer, and is not mitigated by breastfeeding. (Mehr in: Cancer News — ScienceDaily)

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Sprayable gel could help the body fight off cancer after surgery

10. Dez. 2018

A research team has developed a spray gel embedded with immune-boosting drugs that could help lower the risk of cancer recurrence after surgery. (Mehr in: Cancer News — ScienceDaily)

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Some brain tumors may respond to immunotherapy

10. Dez. 2018

A new study suggests that a slow-growing brain tumor arising in patients affected by neurofibromatosis type 1 (NF1) may be vulnerable to immunotherapy, which gives the immune system a boost in fighting cancer. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

26. Wissenschaftliches Symposium für Psychotherapie: Liebe und Partnerschaft

02. Dez. 2018

„Liebe und Partnerschaft“ hat in der heutigen Zeit, in der fast jede zweite Ehe geschieden wird, eine enorme Bedeutung. Tatsächlich befassen sich schon seit Jahrhunderten Philosophen, Ärzte und Psychologen mit diesem Thema. Auf dem Symposium wird es daher aus unterschiedlichen Perspektiven betrachtet – aus Sicht der Psychotherapie, der Sexualmedizin, der Soziologie und der Literaturwissenschaften. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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18. Kongress der DIVI

02. Dez. 2018

Der 18. Kongress der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI) findet vom 05.12.2018 – 07.12.2018 in Leipzig statt. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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4. BfR-Symposium Lebensmittelassoziierte Viren

01. Nov. 2018

Das 4. BfR-Symposium „Lebensmittelassoziierte Viren“ soll einen Austausch über Aspekte wie die aktuelle epidemiologische Situation einzelner Virusinfektionen, neuartige Nachweismethoden für Viren in Lebensmitteln oder Möglichkeiten für eine verbesserte Hygiene ermöglichen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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3. Tag der Arbeitsmedizin in Köln

01. Nov. 2018

Dialogforen Arbeitsmedizin und Arbeitssicherheit – Eine Veranstaltungsreihe für Wissenschaft und Praxis der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. (DGAUM) und RG GmbH (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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38. Marktplatz Gesundheit: „Klinische Bewertung nach der neuen MDR – die Zeit läuft“

01. Nov. 2018

Medizintechnik ist Technik für Menschen. Wer sie entwickelt, herstellt und vertreibt, unterliegt daher besonderen Vorschriften. Maßgeblich dafür ist die EU-Verordnung zu Medizinprodukten (Medical Device Regulation = MDR), welche durch die europäische Zulassung ab 2020 einheitlich geregelt wird. Dies bringt viele Änderungen mit sich. Jeder Hersteller von Medizinprodukten muss sich mit den neuen Anforderungen auseinandersetzen. Es gibt also viel zu bereden! (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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21. Deutsche Mukoviszidose Tagung (DMT)

01. Nov. 2018

Jedes Jahr im November veranstaltet der Mukoviszidose e.V. die Deutsche Mukoviszidose Tagung. An drei Tagen (22.-24.11.2018) wird ein breites Fort- und Weiterbildungsangebot für das interdisziplinäre Mukoviszidose-Behandler-Team präsentiert. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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21. Deutsche Mukoviszidose Tagung

01. Nov. 2018

Die Deutsche Mukoviszidose Tagung – mit jährlich rund 800 Teilnehmerinnen und Teilnehmern die größte Fortbildungsveranstaltung zur Mukoviszidose in Deutschland – richtet sich an das gesamte Behandler-Team und verbindet interdisziplinäre Fragestellungen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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