About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Small difference, significant effect: How antibodies influence the defense against infections

Some autoimmune diseases are successfully treated with monoclonal antibodies (mabs) targeted at inhibiting the release of the inflammatory messenger substance (cytokine) tumor necrosis factor alpha (TNFα). However, TNFα is also important for the defense against pathogenic agents. Researchers at PEI have compared the effects of various mabs for their ability of human immune cells to combat the parasite leishmania. Even a small molecular change (PEGylation) turned out to improve the immune defense against pathogens significantly. The results are reported in Frontiers in Immunology in its online version of 31 July 2018. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

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New findings link estrogen and T cell immune response to autoimmune inflammation

Women are more prone to the development of autoimmune diseases. The female hormone estrogen is likely to affect the immune system. A team of scientists reported new findings related to the involvement of estrogen hormone receptor in autoimmune diseases. (Mehr in: Cancer News — ScienceDaily)

Deciphering the language of cells using observation chambers

Researchers have developed an innovative label-free method for studying the behavior of single cells continuously and in real time. By placing a cell in a small chamber containing nanosensors and observing it over many hours, it is possible to identify the cell’s unique personality and understand how it communicates. This powerful new technology could be used to select the most aggressive cells to combat an enemy. Potential applications include treatments for cancer and autoimmune diseases. (Mehr in: Cancer News — ScienceDaily)

New technology enables identification of biomarkers for a wide range of diseases

Scientists have developed a way to identify biomarkers for a wide range of diseases by assessing the antibodies we are making to the complex sugars coating our cells. The new, highly sensitive Luminex Multiplex Glycan Array enables the kind of volume needed to establish associations between antibody levels in our blood to these complex sugars, or glycans, and conditions from cancer to autoimmune disease and dementia. (Mehr in: Cancer News — ScienceDaily)

Cellular Self-Digestion Process Triggers Autoimmune Disease

Autophagy allows cells to degrade and recycle their cellular components. Researchers at UZH have now demonstrated that the autophagy machinery in certain immune cells leads to the immune system attacking the central nervous system. The researchers are using these findings as a basis to look into new approaches to treating autoimmune diseases such as multiple sclerosis. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Immune cell policing offers insights into cancer, autoimmune disease

Cutting off energy production in regulatory T cells impairs their function, new research has discovered. (Mehr in: Cancer News — ScienceDaily)

Details uncovered in development of immune cell implicated in cancer, autoimmune diseases

Scientists now understand new details about the development of Th17, a type of immune cell that is believed to play a complex role in cancer, and is also implicated in autoimmune diseases. (Mehr in: Cancer News — ScienceDaily)

Mechanism for precise targeting of the immune response uncovered

The immune system checks the health of cells of the body by examining a kind of molecular passport. Sometimes cells present the wrong passport, which can lead to autoimmune diseases, chronic inflammations or cancer. Scientists can now explain the process how this happens. (Mehr in: Cancer News — ScienceDaily)

Preventing autoimmune disease after a viral infection

Researchers used mice to study regulatory mechanisms in the immune system that prevent autoimmune disease. Using an influenza infection model in mice, they have found that a particular population of immune cells developed during the later stages of the immune response to the influenza infection. These cells, called T follicular regulatory cells, subsequently prevented the generation of self-reactive antibody responses. At the same time, they did not affect the influenza-specific immune reaction. (Mehr in: Cancer News — ScienceDaily)

Protein that inhibits the development of autoimmune diseases discovered

The immune system protects humans from threats such as, for example, disease-causing bacteria, and cancer as well. Yet if the system malfunctions, it can attack the body it is supposed to defend and cause autoimmune diseases such as type one diabetes mellitus or multiple sclerosis. Scientists have now demonstrated that the membrane protein Caveolin-1 plays a key role in immune responses that trigger this type of disease. (Mehr in: Cancer News — ScienceDaily)

Cancer news

Chemicals found in vegetables prevent colon cancer in mice

14. Aug. 2018

Chemicals produced by vegetables such as kale, cabbage and broccoli could help to maintain a healthy gut and prevent colon cancer, a new study shows. (Mehr in: Cancer News — ScienceDaily)

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Zombie gene protects against cancer — in elephants

14. Aug. 2018

LIF6, a dead gene that came back to life, prevents cancer by killing cells with DNA damage. (Mehr in: Cancer News — ScienceDaily)

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Potential guidance for gastric cancer treatment

14. Aug. 2018

Researchers have discovered that gastric cancer tissue samples bearing mutation of a specific gene, MUC16, too are associated with higher tumor mutation loads. Also known as tumor mutation burdens, measurement of high genetic mutation rates among cancerous versus healthy tissue has increasingly been shown to correlate with effective response rates to immunotherapy. The knowledge could bode positively for patients with the biomarker present. (Mehr in: Cancer News — ScienceDaily)

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Cancer-fighting drugs also help plants fight disease

14. Aug. 2018

Cancer-fighting drugs used on humans can help plants fight disease as well. That discovery, by plant pathologists, could help scientists develop new pathways for plants to battle infection. (Mehr in: Cancer News — ScienceDaily)

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Stress hormone is key factor in failure of immune system to prevent leukemia

14. Aug. 2018

The human stress hormone cortisol has been identified as a key factor when the immune system fails to prevent leukemia taking hold. (Mehr in: Cancer News — ScienceDaily)

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Cetuximab+RT found to be inferior to standard treatment in HPV+ oropharyngeal cancer

14. Aug. 2018

An interim analysis of data from a randomized clinical trial of patients with human papillomavirus (HPV)-positive oropharyngeal cancer found that treatment with radiation therapy and cetuximab is associated with worse overall and progression-free survival compared to the current standard treatment with radiation and cisplatin. The trial was designed to see if cetuximab with radiation would be less toxic than cisplatin with radiation without compromising survival for patients with the disease. (Mehr in: Cancer News — ScienceDaily)

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E-cigarette vapor disables key immune cells in the lung and boosts inflammation

14. Aug. 2018

E-cigarette vapor boosts the production of inflammatory chemicals and disables key protective cells in the lung that keep the air spaces clear of potentially harmful particles, reveals a small experimental study. (Mehr in: Cancer News — ScienceDaily)

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First study on physical properties of giant cancer cells may inform new treatments

13. Aug. 2018

Giant cancer cells are much larger and stiffer than other cancer cells and move further, study shows. (Mehr in: Cancer News — ScienceDaily)

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Specialized delivery methods to help treat cancer, other disorders

13. Aug. 2018

More than 100 years ago, German Nobel laureate Paul Ehrlich popularized the ‚magic bullet‘ concept — a method that clinicians might one day use to target invading microbes without harming other parts of the body. Although chemotherapies have been highly useful as targeted treatments for cancer, unwanted side effects still plague patients. Now, researchers have demonstrated that specialized nucleic acid-based nanostructures could be used to target cancer cells while bypassing normal cells. (Mehr in: Cancer News — ScienceDaily)

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Medical testing: Drop the C-word to reduce anxiety and overtreatment

13. Aug. 2018

Medical researchers are calling for the word ‚cancer‘ to be dropped from some doctor-patient conversations in a bid to reduce patient anxiety and harm from over treatment. The appeal follows mounting evidence that patients who are told they have ‚cancer‘ for low risk conditions more often choose surgery than those whose condition is described with terms such as ‚lesions‘ or ‚abnormal cells‘. (Mehr in: Cancer News — ScienceDaily)

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Missing immune cells that could fight lethal brain tumors

13. Aug. 2018

Researchers have tracked the missing T-cells in glioblastoma patients. They found them in abundance in the bone marrow, locked away and unable to function because of a process the brain stimulates in response to glioblastoma, to other tumors that metastasize in the brain and even to injury. (Mehr in: Cancer News — ScienceDaily)

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Blood test could detect kidney cancer up to 5 years earlier

13. Aug. 2018

Scientists have discovered that a marker in the blood could help predict the risk that a person will develop kidney cancer. (Mehr in: Cancer News — ScienceDaily)

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Disrupted nitrogen metabolism might spell cancer

13. Aug. 2018

Researchers have now shown that in many cancers, the patient’s nitrogen metabolism is altered, producing detectable changes in the body fluids and contributing to the emergence of new mutations in cancerous tissue. (Mehr in: Cancer News — ScienceDaily)

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‚Undruggable‘ cancers slowed by targeting growth signals

13. Aug. 2018

As many as 50 percent of human cancer cases — across a wide variety of tissues — involve defects in a common cellular growth signaling pathway. These defects have so far defied most attempts to develop targeted therapies. Now researchers have identified a new strategy for potentially treating intractable cancers by decoupling the entire RAS/MAP Kinase (MAPK) signaling pathway from external growth signals. (Mehr in: Cancer News — ScienceDaily)

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Doctor-patient discussions neglect potential harms of lung cancer screening, study finds

13. Aug. 2018

Although national guidelines advise doctors to discuss the benefits and harms of lung cancer screening with high-risk patients because of a high rate of false positives and other factors, those conversations aren’t happening the way they should be, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Major new vulnerability of childhood leukemia uncovered

13. Aug. 2018

A team of researchers has recently uncovered a major new vulnerability of mixed lineage leukemia. Their findings demonstrate that a protein called LEDGF/p75 is regulated by phosphorylation, a molecular modification that changes the electrical charge of the LEDGF/p75 protein. (Mehr in: Cancer News — ScienceDaily)

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Wearable ‚microbrewery‘ saves human body from radiation damage

09. Aug. 2018

The same way that yeast yields beer and bread can help hospital lab workers better track their daily radiation exposure, enabling a faster assessment of tissue damage that could lead to cancer. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

10. TWINCORE Symposium – Frontiers in translational infection research

01. Aug. 2018

Am 31. August 2018 begrüßen wir zum 10. Mal Wissenschaftlerinnen und Wissenschaftler asu der ganzen Welt zum TWINCORE Symposium. Internationale Experten führen durch aktuelle Entwicklungen der translationalen Infektionsforschung.

http://www.twincore.de/twincore/

Nähere Informationen folgen… (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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OSTSEETAG

01. Aug. 2018

Wer Ostsee-Expertenwissen braucht, ist hier richtig: 3. Ostseetag im Stadthafen Rostock! (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Klinische Bewertung medizinischer Software

01. Aug. 2018

Für jedes Medizinprodukt muss der Hersteller anhand klinischer Daten die Eignung für die vorgesehene Verwendung nachweisen und die klinischen Risiken vor dem Hintergrund des zu erwartenden Nutzens für den Patienten bewerten. Dies ist ein kontinuierlicher Prozess, der sich bis zur klinischen Nachbeobachtung nach dem Inverkehrbringen erstreckt. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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„Blue Biotechnology in the Baltic Sea Region – from Science to Business“

01. Aug. 2018

Es ist uns eine große Freude, Sie zu der internationalen Konferenz „Blue Biotechnology in the Baltic Sea Region – from Science to Business“ einzuladen. Rund 100 Wissenschaftler, Unternehmer und Interessenvertreter aus dem Umfeld der marinen Biotechnologie werden vom 22. bis zum 24. August 2018 neueste Resultate aus Forschung und Entwicklung sowie erfolgreiche ökonomische Umsetzungen präsentieren. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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12th International Conference and Workshop on Biological Barriers

01. Aug. 2018

Biological Barriers is an international scientific event , organized every two years and receiving constantly 200+ registered attendees from all over the world. In the focus of BioBarriers are human cell and tissue models for facilitating clinical translation of new drugs and delivery systems, especially in the context of infectious diseases. Moreover, we will discuss innovative concepts and materials, also capable to overcome non-cellular diffusion barriers such as mucus or bacterial biofilms. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Personenzentrierung

01. Jul. 2018

Personenzentrierung: Bausteine für einen heilsamen Umgang bei Menschen mit Demenz zwischen Anspruch und Wirklichkeit. Auch im akademischen Jahr 2017/18 bietet die Philosophisch-Theologische Hochschule Vallendar (PTHV) wieder für die interessierte Öffentlichkeit eine Ringvorlesung an – dieses Mal zum Thema „Heil und Heilung“. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Neue Entwicklungen des Rechts auf Gesundheit in Brasilien

01. Jul. 2018

Die brasilianische Bundesverfassung von 1988 enthält einen großzügigen Katalog sozialer Grundrechte, innerhalb dessen dem Recht auf Gesundheit eine besondere Bedeutung zukommt. Prof. Dr. Ingo Sarlet zeigt die jüngsten Entwicklungen hinsichtlich der Realisierung dieses Rechts auf. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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