Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

[ read more ]

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

[ read more ]

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

[ read more ]

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

[ read more ]

Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

[ read more ]

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

[ read more ]

Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

[ read more ]

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

[ read more ]

Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

[ read more ]

Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

[ read more ]

Rewriting the textbook on how steroid hormones enter cells

A discovery may open up new ways to control steroid hormone-mediated processes, including growth and development in insects, and sexual maturation, immunity, and cancer progression in humans. (Mehr in: Cancer News — ScienceDaily)

In depression the brain region for stress control is larger

Although depression is one of the leading psychiatric disorders in Germany, its cause remains unclear. A recent study at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) in Leipzig, Germany, and the Department of Psychiatry and Psychotherapy of the University Clinic in Leipzig found that those affected by depressive disorder have a larger hypothalamus compared to their healthy counterparts. This could explain why many sufferers show increased levels of the stress hormone cortisol and are very often afflicted with periods of tension. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

DGE: Anti-Aging-Hormone halten meist nicht, was sie versprechen

Mit dem Altern geht die Abnahme verschiedener körpereigener Hormone einher. Um diesen „Mangel“ auszugleichen, gibt es einen großen Markt für Hormonersatzpräparate, etwa die Gabe von Testosteron, Wachstumshormon, dem Zirbeldrüsenhormon Melatonin oder Dehydroepiandrosteron (DHEA). Doch substantielle Anti-Aging-Effekte bezüglich dieser Hormongaben seien nicht belegt, sagt die Deutsche Gesellschaft für Endokrinologie (DGE) anlässlich der 3. Deutschen Hormonwoche. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Studie an menschlichen Spermien entschlüsselt schädliche „Cocktail-Effekte“ von Alltagschemikalien

Hormonell wirksame Alltagschemikalien könnten mitverantwortlich sein für Fruchtbarkeitsstörungen, die in der westlichen Welt immer häufiger auftreten. Ein deutsch-dänisches Forscherteam hat diese Chemikalien unter die Lupe genommen. Das Fazit: Kombiniert man die Chemikalien, addieren sich die Einzelwirkungen nicht nur, sondern sie verstärken sich gegenseitig. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Immer der Nase nach: Bestimmte Frauen sind für Männer besonders dufte

Sexualhormone steuern den Monatszyklus der Frau, sorgen für ihre Fruchtbarkeit – und sie sorgen für einen wohlriechenden Körpergeruch. Wie Forschende der Universität Bern nun zeigen, duften einige Frauen in Männernasen besser als andere. Nämlich diejenigen, die für die Fortpflanzung am «fittesten» sind. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Hormone therapy can make prostate cancer worse, study finds

Scientists have discovered how prostate cancer can sometimes withstand and outwit a standard hormone therapy, causing the cancer to spread. Their findings also point to a simple blood test that may help doctors predict when this type of hormone therapy resistance will occur. (Mehr in: Cancer News — ScienceDaily)

Effect of radiation exposure on hormone deficiencies

Researchers have detailed the effect of radiation exposure on the development of hormone deficiency in pediatric and young adult patients treated for brain tumors. (Mehr in: Cancer News — ScienceDaily)

Stress hormone is key factor in failure of immune system to prevent leukemia

The human stress hormone cortisol has been identified as a key factor when the immune system fails to prevent leukemia taking hold. (Mehr in: Cancer News — ScienceDaily)

Übergewichtige Kinder und Teenager: Nicht immer sind die Hormone schuld

Endokrinologen empfehlen: Energiebilanz beachten – weniger essen, mehr bewegen

*************************************************************************************************

Seit Mitte der 1970er Jahre sind weltweit immer mehr Kinder und Jugendliche übergewichtig oder adipös. Auch wenn Gene zu etwa 50 Prozent für Körpergewicht und Fettmasse bei Heranwachsenden verantwortlich sind, erklärt dies nach Ansicht der Deutschen Gesellschaft für Endokrinologie e.V. (DGE) nicht allein die große Anzahl Betroffener in dieser Altersgruppe. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Low-protein diet during pregnancy increases prostate cancer risk in offspring, rat study shows

Experiments with rats show that intrauterine protein restriction induces sex hormone imbalance, which appears to favor development of cancer in old age. The rate of prostate tumor development reached 50 percent among the old rats submitted to low-protein diet during pregnancy and lactation alike. (Mehr in: Cancer News — ScienceDaily)

Cancer news

Frog eggs help researchers understand repair of DNA damages

23. Jan. 2019
The DNA replication process, which takes place every time a cell divides, also triggers repair of DNA damage, researchers have described in a new study. Scientists have studied extracts from frog eggs, whose proteins are very similar to those of human cells. The researchers hope the new research results can be used to develop more effective treatments for cancer in the long run.

Quelle: Sciencedaily

- Read more

New nanoparticle targets tumor-infiltrating immune cells, flips switch

22. Jan. 2019
A team of Vanderbilt University bioengineers today announced a major breakthrough in penetrating the cells inside tumors and flipping on a switch that tells them to start fighting.

Quelle: Sciencedaily

- Read more

Cancer survivors face significant hardships related to medical bills

22. Jan. 2019
New research indicates that cancer survivors carry greater financial burdens related to medical debt payments and bills compared with individuals without a cancer history, with the greatest hardships in younger survivors.

Quelle: Sciencedaily

- Read more

Energizing the immune system to eat cancer

22. Jan. 2019
Researchers say they’ve identified how to fuel macrophages with the energy needed to attack and eat cancer cells.

Quelle: Sciencedaily

- Read more

Killer blows? Knockout study of pair of mouse MicroRNA provides cancer insight

21. Jan. 2019
Researchers used knockout mouse models created by gene editing to reveal that the miRNA miR-146b, like miR-146a, is involved in the development of cancers, with them having similar but not identical effects. The knockout mice should help in the fight against cancers involving miRNA dysregulation.

Quelle: Sciencedaily

- Read more

New therapeutic avenue in the fight against chronic liver disease

21. Jan. 2019
A recent study, affiliated with South Korea’s Ulsan National Institute of Science and Technology (UNIST) has introduced a novel targeted drug delivery system in the fight against cancer.

Quelle: Sciencedaily

- Read more

Scientists create a renewable source of cancer-fighting T cells

21. Jan. 2019
A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells — which can give rise to every cell type in the body and which can be grown indefinitely in the lab — into becoming mature T cells capable of killing tumor cells.

Quelle: Sciencedaily

- Read more

Researchers race against extinction to uncover tree’s cancer-fighting properties

21. Jan. 2019
As the population of a fir tree in China dwindles, researchers are racing to replicate its cancer-fighting molecules.

Quelle: Sciencedaily

- Read more

Scientists learn how common virus reactivates after transplantation

21. Jan. 2019
A new study challenges long-held theories of why a common virus — cytomegalovirus, or CMV — can reactivate and become a life-threatening infection in people with a compromised immune system, including blood cancer patients undergoing bone marrow transplantation.

Quelle: Sciencedaily

- Read more

Stopping cancer from recruiting immune system double agents

05. Jan. 2019

Cancerous tumors trick myeloid cells, an important part of the immune system, into perceiving them as a damaged part of the body; the tumors actually put myeloid cells to work helping them grow and metastasize (spread). Researchers have now discovered a potential therapy that can disrupt this recruitment and abnormal function of myeloid cells in laboratory mice. (Mehr in: Cancer News — ScienceDaily)

- Read more

New mechanism to ‚activate‘ the immune system against cancer

04. Jan. 2019

A new mechanism for activating the immune system against cancer cells allows immune cells to detect and destroy cancer cells better than before, and most effectively in lung cancer and melanoma. (Mehr in: Cancer News — ScienceDaily)

- Read more

Essential amino acid in humans, methionine, controls cell growth

04. Jan. 2019

A recent study from the Laxman lab elucidates how a small metabolite and amino acid, methionine, acts as a growth signal for cells, by setting into motion a metabolic program for cell proliferation. (Mehr in: Cancer News — ScienceDaily)

- Read more

Genetic testing does not cause undue worry for breast cancer patients

04. Jan. 2019

As genetic testing for breast cancer has become more complex, evaluating a panel of multiple genes, it introduces more uncertainty about the results. But a new study finds that newer, more extensive tests are not causing patients to worry more about their cancer risk. (Mehr in: Cancer News — ScienceDaily)

- Read more

‚Christmas berry‘ plant compound could fight Uveal melanoma

04. Jan. 2019

A molecule derived from a type of primrose could prove to be a potent inhibitor of metastatic growth for a rare and aggressive cancer. (Mehr in: Cancer News — ScienceDaily)

- Read more

Experimental treatment shows promise against triple-negative breast cancer

03. Jan. 2019

A naturally occurring protein called Tinagl1 reduced the spread of triple-negative breast cancer in a study conducted in mice. (Mehr in: Cancer News — ScienceDaily)

- Read more

An errant editing enzyme promotes tumor suppressor loss and leukemia propagation

03. Jan. 2019

Researchers have found a stem cell enzyme copy edits more than 20 tumor types, providing new therapeutic target for preventing cancer cell resistance to chemotherapy and radiation. (Mehr in: Cancer News — ScienceDaily)

- Read more

Cancer cells steer a jagged path

03. Jan. 2019

Researchers define the role of a jagged ligand, JAG1, in cancer cells‘ ability to differentiate and metastasize, making them harder to track down and eliminate. (Mehr in: Cancer News — ScienceDaily)

- Read more

Veranstaltungen

ANIM 2019

01. Jan. 2019

36. Gemeinsame Jahrestagung der Deutschen Gesellschaft für NeuroIntensiv- und Notfallmedizin (DGNI) und der Deutschen Schlaganfall-Gesellschaft (DSG) (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

Advances in Chemical Biology

01. Jan. 2019

The upcoming Advances in Chemical Biology conference will feature latest research from all hot topics in chemical biology, especially target Discovery, synthetic biomolecules and new genetic codes (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

2nd International GlycoBioTec Symposium – 28 to 30 January 2019

01. Jan. 2019

The Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg is pleased to welcome you to Berlin for the International GlycoBioTec symposium at the Harnack House. GlycoBioTec 2019 brings together opinion leaders, pioneers, experts, professionals and newbies to discuss current trends in modern biomedical/biopharmaceutical glycobiotechnology in a focused manner. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

2nd DZHK Conference on Translational Medicine | "Paving the way to new therapies"

01. Jan. 2019

We are delighted to be holding the 2nd DZHK Conference on Translational Medicine in January of 2019 in Berlin. Please join us and a number of internationally renowned experts in a vivid exchange on translation across the disciplines. Registration starts on 17 September 2018 and ends on 30 November 2018. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

2. Internationales GlycoBioTec Symposium – 28. bis 30. Januar 2019

01. Jan. 2019

Das Max-Planck-Institut für Dynamik komplexer technischer Systeme Magdeburg heißt Sie zum Internationalen GlycoBioTec Symposium im Harnack Haus Berlin willkommen. GlycoBioTec 2019 bringt Experten, Meinungsführer, Vorreiter, Anwender und Neulinge zu aktuellen Entwicklungen in der modernen biomedizinischen/biopharmazeutischen Glykobiotechnologie zusammen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

Frugale Innovationen – Chancen nutzen für neue Märkte

01. Jan. 2019

Einfach, erschwinglich, kundenzentriert – auf diesen Nenner lassen sich frugale Innovationen bringen. Ursprünglich für Märkte in Schwellen- und Entwicklungsländern konzipiert, treffen frugale Lösungen auch in Europa auf einen wachsenden Bedarf.

Es werden vermehrt robuste und nachhaltige Produkte von guter Qualität gewünscht, die technologisch einfacher und benutzerfreundlicher sind. Aber: Wie passen meine Produkte/Leistungen in dieses Konzept? Welche Kunden und Märkte kann ich damit erreichen? (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

Fachtag „Praxis erforschen“

01. Jan. 2019

Am 18. Januar 2019 findet an der Evangelischen Hochschule für Soziale Arbeit & Diakonie in Hamburg der Fachtag „Praxis erforschen“ statt. Es werden Forschungsergebnisse aus den Handlungsfeldern Jugendhilfe, Drogenhilfe, Sozialpsychiatrie, Hilfen für Menschen mit Behinderungen und Diakoniemanagement präsentiert. Alle Interessierten sind hierzu herzlich eingeladen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen