Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Blocking digestive hormone may prevent diet-induced pancreatic cancer

A high-fat diet may promote the growth of pancreatic cancer independent of obesity because of the interaction between dietary fat and cholecystokinin (CCK), a digestive hormone. In addition, blocking CCK may help prevent the spread of pancreatic tumors to other areas of the body (metastases). (Mehr in: Cancer News — ScienceDaily)

Fight or flight? Sexual cycle determines the behaviour of female guinea pigs

Due to a stabile social hierarchy, guinea pigs rely on their intuition to decide whether to compete or to escape. So far, there has been limited research on how the sexual cycle may shape female social behaviour in animals. Researchers from the University of Veterinary Medicine, Vienna, and the University of Vienna showed now that flight was the preferred strategy during experimental confrontation of two females during oestrus. If the animals were not ready to mate, however, their stress hormone level increased stronger and physical contact was more frequent. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Mother-Child Communication in Plants

Researchers decipher how plants steer the development of their embryos using hormones (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

RNA molecules that regulate action of male hormone in prostate cancer identified

A study detected in tumoral tissue hundreds of RNAs that do not encode proteins but appear to regulate effects of androgens and androgen receptors on gene expression in tumors. By investigating the connection between the presence of these molecules and tumor aggressiveness, the research paves the way for new scientific approaches focusing on the transcription process of noncoding RNA. (Mehr in: Cancer News — ScienceDaily)

Plant mothers talk to their embryos via the hormone auxin

Scientists solve long-standing question about signal that regulates embryo development – Study in Nature Plants (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Testosterone research brings new hope for cancer patients

Approximately 20 percent of cancer related deaths are attributed to the syndrome of cachexia. Medical researchers now show that the hormone testosterone is effective at combating cachexia in cancer patients and improving quality of life. (Mehr in: Cancer News — ScienceDaily)

Up to half of childhood cancer survivors will develop hormone disorders

The Endocrine Society today issued a Clinical Practice Guideline advising healthcare providers on how to diagnose and treat the endocrine disorders that affect a significant portion of childhood cancer survivors in the United States today. (Mehr in: Cancer News — ScienceDaily)

New mechanism for the plant hormone auxin discovered

Study in Nature Plants reveals a new mechanism in roots’ response to gravity. Auxin is a hormone that is essential for the development of plants as it controls a wide range of processes from shaping the embryo in the seed to branching of the growing plant. Previously, it was believed that auxin’s main signaling mechanism operated in the cell nucleus and acted only by regulating gene transcription. Now, scientists led by Jiří Friml at the Institute of Science and Technology Austria (IST Austria) have demonstrated that another mechanism exists, and that cells in the roots must be able to respond […]

DGE/DDG-Pressekonferenz: Seltene Hormonerkrankungen als Ursache für Diabetes in Betracht ziehen

Berlin – Für die Diagnose von Diabetes ist ein erhöhter Blutzuckerspiegel ein zentraler Hinweis auf die Stoffwechselstörung. Die Ursachen dafür können auch in einer Überproduktion anderer lebensnotwendiger Hormone liegen. Gegenspieler des Insulins, das für die Senkung des Blutzuckerspiegels verantwortlich ist, können den Zuckerstoffwechsel stark beeinflussen. Welche Rolle das Stresshormon Cortisol und Wachstumshormone in diesem Zusammenhang spielen und welche gut behandelbaren Hormonerkrankungen wie der Morbus Cushing oder die Akromegalie dahinterstehen können, erläutern Experten auf einer Pressekonferenz am 28. Juni 2018 in Berlin. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Breast cancer could be prevented by targeting epigenetic proteins, study suggests

Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study suggests that inhibiting these proteins with drugs could prevent the development of breast cancer in women at high risk of the disease. (Mehr in: Cancer News — ScienceDaily)

Cancer news

New way to determine whether metastatic cancer cells in breast cancer patients are dormant or soon to turn deadly

16. Okt. 2018

For the first time ever, researchers have identified a protein as a marker that can indicate whether a cancer patient will develop a recurrence of lethal, metastatic cancer. (Mehr in: Cancer News — ScienceDaily)

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Finding better drug ‚fits,‘ avoiding medication tragedies like thalidomide

15. Okt. 2018

Researchers, including chemistry professor and Nobel Prize winner Ei-ichi Negishi, have developed technology to create a new chemical process to synthesize drug-like molecules with ultra-high purity. (Mehr in: Cancer News — ScienceDaily)

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3D mammography detected 34 percent more breast cancers in screening

15. Okt. 2018

After screening 15,000 women over a period of five years, a major clinical study in Sweden has shown that 3D mammography, or breast tomosynthesis, detects over 30% more cancers compared to traditional mammography — with a majority of the detected tumors proving to be invasive cancers. (Mehr in: Cancer News — ScienceDaily)

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More clues revealed in link between normal breast changes and invasive breast cancer

15. Okt. 2018

A research team details how a natural and dramatic process — changes in mammary glands to accommodate breastfeeding — uses a molecular process believed to contribute to survival of pre-malignant breast cells. (Mehr in: Cancer News — ScienceDaily)

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Cells‘ route in response to disease is not always straight

15. Okt. 2018

The steps cells take in response to challenges are more complex than previously thought, finds new research. The study investigates a system relevant to cancer, viral infection, and diabetes. (Mehr in: Cancer News — ScienceDaily)

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Cancer stem cells use normal genes in abnormal ways

12. Okt. 2018

An new study shows that CDK1 directly interacts with Sox2 to keep cancer cells ‚stemmy.‘ (Mehr in: Cancer News — ScienceDaily)

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New model mimics human tumors for accurate testing of cancer drugs

11. Okt. 2018

Researchers have genetically engineered a new laboratory model that enables accurate testing of anti-cancer drugs by mimicking the complexity of human cancers. Using this advanced model, researchers will be able to discover the safest and most effective ways to use promising drugs called MCL-1 inhibitors in the clinic. (Mehr in: Cancer News — ScienceDaily)

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Redrawing the structure of an immune system protein

10. Okt. 2018

Researchers have revealed the structure of an essential immune protein, creating future possibilities to develop more effective medicines for a range of illnesses from cancer to neurological diseases. Researchers made this discovery with computerized image analysis and modern electron microscope imaging. (Mehr in: Cancer News — ScienceDaily)

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Path to deadly sepsis varies by bacterial infection

10. Okt. 2018

Sepsis remains a common and deadly condition that occurs when the body reacts to an infection in the bloodstream. However, scientists know little about the early stages of the condition. Now, researchers have discovered that host responses during sepsis progression can vary in important ways based on pathogen type — which could lead to more effective treatments. (Mehr in: Cancer News — ScienceDaily)

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Air pollution may be linked to heightened mouth cancer risk

10. Okt. 2018

High levels of air pollutants, especially fine particulate matter (PM2.5) and to a lesser extent, ozone, may be linked to a heightened risk of developing mouth cancer, suggests the first study of its kind. (Mehr in: Cancer News — ScienceDaily)

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Supercharged natural killer cells may hold promise for cancer

09. Okt. 2018

New research suggests that a type of ‚supercharged‘ immune cell could be mass-produced to help fight cancer. (Mehr in: Cancer News — ScienceDaily)

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Statins show little promise for conditions other than heart disease

09. Okt. 2018

Medicines commonly prescribed to reduce people’s risk of heart attack may have limited use for treating other diseases, research suggests. (Mehr in: Cancer News — ScienceDaily)

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Immunotherapy effective against hereditary melanoma

09. Okt. 2018

Individuals with an inherited form of skin cancer often have a poor prognosis. The type of immunotherapy that was awarded this year’s Nobel Prize in Physiology or Medicine is, however, particularly effective in this patient group, new research shows. (Mehr in: Cancer News — ScienceDaily)

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Mechanism of resistance to novel targeted therapy for ovarian cancer identified

09. Okt. 2018

Scientists have unraveled a mechanism of resistance to EZH2 inhibitors in ovarian cancers with mutations in the ARID1A gene. (Mehr in: Cancer News — ScienceDaily)

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Neoadjuvant combination checkpoint blockade trial yields high response rates for patients with high-risk stage three melanoma

08. Okt. 2018

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage three melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early. (Mehr in: Cancer News — ScienceDaily)

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There’s a better way to decipher DNA’s epigenetic code to identify disease

08. Okt. 2018

A new method for sequencing the chemical groups attached to the surface of DNA is paving the way for better detection of cancer and other diseases in the blood. These chemical groups mark one of the four DNA ‚letters‘ in the genome, and it is differences in these marks along DNA that control which genes are expressed or silenced. (Mehr in: Cancer News — ScienceDaily)

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Novel technology enables detection of early-stage lung cancer when surgical cure still is possible

08. Okt. 2018

To improve outcomes for patients with non-small-cell lung carcinoma researchers are developing a blood test to detect lung cancer earlier in the disease. A report describes a new technology, electric field-induced release and measurement (EFIRM) that is both highly sensitive and specific in detecting two epidermal growth factor receptor (EGFR) mutations associated with lung cancer in the blood of NSCLC patients with early-stage disease. This platform is relatively inexpensive and capable of high-throughput testing. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

13. ITG Fachtagung Sprachkommunikation

09. Okt. 2018

Die Tagung der Informationstechnischen Gesellschaft (ITG), einer Fachgesellschaft des Verbands der Elektrotechnik, Elektronik, Informationstechnik (VDE), ist eins der größten Treffen von Wissenschaftlern und Praktikern auf dem Gebiet der Sprachverarbeitung im deutschsprachigen Raum. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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62. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V.

01. Okt. 2018

Bereits zum zweiundsechzigsten Mal findet 2018 der Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V. statt. Vom 31. Oktober bis 3. November diskutieren über 5.000 Expertinnen und Experten im Berliner CityCube den aktuellen Stand der Wissenschaft und Forschung sowie die Zukunft des Fachgebiets der Frauenheilkunde und Geburtshilfe. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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5th International Conference on Cellular Materials (CellMAT), 24 – 26 October

01. Okt. 2018

The 5th CellMAT conference will cover all aspects of manufacturing, functionalizing, modification, joining, property analysis and modelling of cellular materials. In addition to this, featured side events will focus on specific topics. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Einführung in die additive Fertigung

01. Okt. 2018

Das Thema additive Fertigung, d.h. der direkte schichtweise Aufbau von Produkten, ist aktuell sehr stark in das Interesse der polymer- und metallverarbeitenden Industrie sowie des produzierenden Gewerbes gerückt. Allein basierend auf 3D-Konstruktionsdaten können auf verschiedene Weisen Bauteile mit integrierten Funktionalitäten ohne Verwendung eines Werkzeuges realisiert werden, die konventionell so nicht herstellbar sind. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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CISCEM 2018 – 4th International Conference on In Situ and Correlative Electron Microscopy

01. Okt. 2018

CISCEM aims at bringing together an interdisciplinary group of scientists from the fields of biology, materials science, chemistry, and physics, to discuss future directions of in-situ electron microscopy research. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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BfR-Akademie Fortbildung: Transfer von Stoffen entlang der Nahrungskette – Teil 2

01. Okt. 2018

https://www.bfr-akademie.de/deutsch/veranstaltungen/transfer2.html (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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7T and beyond: 12th Erwin L. Hahn Lecture

01. Okt. 2018

Höher, schneller, weiter – die immer größer werdenden Feldstärken der MRTs erlauben einmalige und faszinierend detaillierte Aufnahmen aus dem Innern des menschlichen Körpers. Aber bringt die Ultra-Hochfeld-MRT auch Nachteile mit sich? Welchen Schwierigkeiten sehen sich die Forscher und Mediziner bei solch hohen Magnetfeldstärken ausgesetzt? Mit diesen und anderen Fragen beschäftigt sich die diesjährige Erwin L. Hahn Workshop & Lecture unter dem Thema „7T and Beyond“. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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