Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

[ read more ]

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

[ read more ]

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

[ read more ]

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

[ read more ]

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

[ read more ]

Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

[ read more ]

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

[ read more ]

Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

[ read more ]

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

[ read more ]

Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

[ read more ]

How cells stress-out differently

The release of stress hormones triggers a wide variety of different responses in the organism. Some of these responses are controlled by so-called enhancers, regulatory regions in the genome, which influence the activity of genes. Scientists at the Max Planck Institute for Molecular Genetics (MPIMG) in Berlin now found that an individual enhancer can contribute to distinct stress responses in different cell types. This is because the shared enhancer regulates the expression of different gene transcripts in the distinct cell types thereby facilitating cell-type specific responses to stress. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Wie Zellen unterschiedlich auf Stress reagieren

Die Freisetzung von Stresshormonen löst zahlreiche unterschiedliche Reaktionen im Organismus aus. Einige dieser Reaktionen werden durch sogenannte Enhancer reguliert. Dies sind regulatorische Regionen im Genom, die die Aktivität von Genen beeinflussen können. Wissenschaftlerinnen und Wissenschaftler am Berliner Max-Planck-Institut für molekulare Genetik (MPIMG) haben jetzt herausgefunden, dass ein einzelner Enhancer in verschiedenen Zelltypen unterschiedliche Stressreaktionen regulieren kann. Dies ist möglich, da der Enhancer in unterschiedlichen Zelltypen die Produktion von verschiedenen Gentranskripten reguliert und dadurch zelltypspezifische Reaktionen auf Stress ermöglicht. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Some viruses produce insulin-like hormones that can stimulate human cells — and have potential to cause disease

Scientists have identified four viruses that can produce insulin-like hormones that are active on human cells. The discovery brings new possibilities for revealing biological mechanisms that may cause diabetes or cancer. (Mehr in: Cancer News — ScienceDaily)

Moulds produce plant growth hormone

Kiel research team describes the auxin synthesis mechanisms in the fungus Neurospora crassa for the first time

Plants, bacteria and various fungi produce a specific group of hormones known as auxins. Together with other hormones, they cause plant cells to stretch and thus, for example, the rapid growth of young shoots. The manner in which plants produce these substances has been intensively studied for decades, and is accordingly described in great detail. In contrast, how this biosynthesis takes place in fungi has hardly been studied to date. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Schimmelpilze bilden pflanzliches Wachstumshormon

Pflanzen, Bakterien und verschiedene Pilze bilden eine bestimmte Gruppe von Hormonen, die als Auxine bezeichnet werden. Sie sorgen gemeinsam mit anderen Hormonen für eine Streckung der Pflanzenzellen und damit zum Beispiel für das schnelle Wachstum junger Sprosse. Die Art und Weise, wie Pflanzen diese Stoffe herstellen, wurde seit Jahrzehnten intensiv erforscht und ist entsprechend umfassend beschrieben. Wie diese sogenannte Biosynthetisierung hingegen bei Pilzen abläuft, ist bislang nur wenig untersucht. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Paarbindung mit gewissen Vorzügen

Waldrapp: Positiver Effekt auf Immunsystem und Parasitenbelastung

Die Brutsaison ist für Waldrapp-Eltern sehr herausfordernd, wodurch das Immunsystem der Vögel zusätzlich belastet ist und damit ein erhöhtes Infektionsrisiko besteht. Gute soziale Beziehungen könnten jedoch stressverringernd wirken. Das hat ein Team der Konrad Lorenz Forschungsstelle (KLF) der Universität Wien um Verena Pühringer-Sturmayr gemeinsam mit der Anglia Ruskin University (Cambridge) und der Veterinärmedizinischen Universität Wien herausgefunden. Die ForscherInnen begleiteten die Waldrappe während und außerhalb der Brutzeit und untersuchten die Stresshormone der Tiere. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Estrogen causes neuroblastoma cells to mature into neurons

The female sex hormone estrogen can perform an important role in neuroblastoma, a form of cancer mainly affecting young children. In laboratory experiments, researchers demonstrate that estrogen treatment and overexpression of the estrogen receptor cause malignant neuroblastoma cells to mature into neuron-like cells. The studygives hope of new treatment possibilities. (Mehr in: Cancer News — ScienceDaily)

Wechseljahre: Taugen Hormone als Stimmungsaufheller?

Hormonbehandlungen zur Linderung von Beschwerden in den Wechseljahren erleben eine Renaissance. Nun zeichnet sich ein weiterer Grund für den Einsatz von Hormonen ab.

(Mehr in: Medizin & Ernährung – FAZ.NET)

An interaction map displaying how the receptor kinases interact with one another

In both plants and animals, a family of proteins named receptor kinases are largely responsible for sensing the environment. Plants use receptor kinases as ‘molecular antennas’ to recognize chemical signals, such as growth hormones or portions of proteins from pathogens, from outside the cell and initiate responses to this signal inside the cell. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Novel complementary effects of estrogen treatment in multiple sclerosis

A study reveals the cellular basis for how the hormone protects against damage to the central nervous system. (Mehr in: Cancer News — ScienceDaily)

Cancer news

Gut microbiome can control antitumor immune function in liver

24. Mai. 2018

Scientists have found a connection between bacteria in the gut and antitumor immune responses in the liver. Bacteria found in the gut of mice affect the liver’s antitumor immune function. The findings have implications for understanding the mechanisms that lead to liver cancer and for therapeutic approaches to treat them. (Mehr in: Cancer News — ScienceDaily)

- Read more

Cancer cells co-opt pain-sensing ‚wasabi receptor‘ to survive oxidative stress

24. Mai. 2018

Some cancers express unusually high levels of a neural calcium channel known as the ‚wasabi receptor,‘ which plays a role in detecting pain, cold and other sensations. New research finds cancer cells co-opt this neural channel to increase their tolerance against toxic oxidative stress. Blocking the activity of this channel in mice curbs tumor growth and makes cancer cells more sensitive to chemotherapy. (Mehr in: Cancer News — ScienceDaily)

- Read more

3D printed sugar offers sweet solution for tissue engineering, device manufacturing

24. Mai. 2018

Engineers built a 3D printer that offers a sweet solution to making detailed structures that commercial 3D printers can’t: Rather than a layer-upon-layer solid shell, it produces a delicate network of thin ribbons of hardened isomalt, the type of sugar alcohol used to make throat lozenges. The water-soluble, biodegradable glassy sugar structures have multiple applications in biomedical engineering, cancer research and device manufacturing. (Mehr in: Cancer News — ScienceDaily)

- Read more

Genes of different importance for brain cancer

24. Mai. 2018

Two genes play important roles for the formation of malignant cancer in the brain. One gene prevents the formation of the tumor, while another gene promotes the tumor. (Mehr in: Cancer News — ScienceDaily)

- Read more

Painless real-time proteomics may one day speed up cancer surgery

23. Mai. 2018

Researchers have developed a matrix-assisted ion source for mass spectrometry that can liberate lipids and metabolites from the skin without causing pain. Now, they have optimized protein measurement using this device. The device can be used to differentiated normal from cancerous tissues. (Mehr in: Cancer News — ScienceDaily)

- Read more

Embryonic mammary gland stem cells identified

22. Mai. 2018

Scientists have identified the mechanisms that regulate mammary gland development. Using a combination of lineage tracing, molecular profiling, single cell sequencing and functional experiments, they have demonstrated that mammary gland initially develops from multipotent progenitors during the early steps of embryonic mammary gland morphogenesis whereas postnatal mammary gland development is mediated by lineage-restricted stem cells. (Mehr in: Cancer News — ScienceDaily)

- Read more

New data changes the way scientists explain how cancer tumors develop

21. Mai. 2018

A collaborative research team has uncovered new information that more accurately explains how cancerous tumors grow within the body. This study is currently available in Nature Genetics. (Mehr in: Cancer News — ScienceDaily)

- Read more

Deep space radiation treatment reboots brain’s immune system

21. Mai. 2018

NASA and private company SpaceX plan to send humans to Mars within the next 15 years — but need to figure out how to protect astronauts from the dangerous cosmic radiation of deep space. Now neuroscientists have identified a potential treatment for the brain damage caused by cosmic rays — a drug that prevents memory impairment in mice exposed to simulated space radiation. (Mehr in: Cancer News — ScienceDaily)

- Read more

Are humans causing cancer in wild animals?

21. Mai. 2018

As humans, we know that some of our activities can cause cancer to develop in our bodies. Smoking, poor diets, pollution, chemicals used as additives in food and personal hygiene products, and even too much sun can contribute to an increased risk of cancer. But, are human activities also causing cancer in wild animals? Researchers think so and are urgently calling for research into this topic. (Mehr in: Cancer News — ScienceDaily)

- Read more

Scientist reveals likely cause of childhood leukemia

21. Mai. 2018

A major new analysis reveals for the first time the likely cause of most cases of childhood leukemia, following more than a century of controversy about its origins. (Mehr in: Cancer News — ScienceDaily)

- Read more

Fewer men are being screened, diagnosed, and treated for prostate cancer

21. Mai. 2018

A new study reveals declines in prostate cancer screening and diagnoses in the United States in recent years, as well as decreases in the use of definitive treatments in men who have been diagnosed. (Mehr in: Cancer News — ScienceDaily)

- Read more

MR spectroscopy imaging reveals effects of targeted treatment of mutant IDH1 gliomas

18. Mai. 2018

Using a novel imaging method, a research team is investigating the mechanisms behind a potential targeted treatment for a subtype of the deadly brains tumors called gliomas. (Mehr in: Cancer News — ScienceDaily)

- Read more

A way to prevent pancreatic cancer from spreading post-surgery?

17. Mai. 2018

New research suggests a strategy for lowering the odds of metastasis following successful pancreatic cancer surgery: The post-operative period, suggests a researcher, ‚offers a window during which efforts might be made to keep cortisol levels down and T cells strong so the patient’s own immune system can kill the cancer cells that have made their way to other parts of the body but until this point have been dormant.‘ (Mehr in: Cancer News — ScienceDaily)

- Read more

Immune cell provides cradle for mammary stem cells

17. Mai. 2018

Researchers have made new discoveries about how an immune cell known as the macrophage, which normally fights infection by swallowing foreign invaders, nurtures mammary gland stem cells through a chemical signaling molecule. The study may provide important clues about the roles of macrophages in breast cancer progression. (Mehr in: Cancer News — ScienceDaily)

- Read more

Single surface protein boosts multiple oncogenic pathways in acute myeloid leukemia

17. Mai. 2018

Researchers have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought. The study raises hopes that current efforts to target this signaling protein could be a successful strategy to treat AML and other blood cancers. (Mehr in: Cancer News — ScienceDaily)

- Read more

La Trobe’s infection-busting discovery

17. Mai. 2018

Scientists have shown a protein found in a tobacco plant has the potential to fight life-threatening infectious diseases. (Mehr in: Cancer News — ScienceDaily)

- Read more

Individualized ovarian, brain cancer therapies

16. Mai. 2018

Researchers have discovered that a molecular communication pathway — thought to be defective in cancer — is a key player in determining the effectiveness of measles virus oncolytic cancer treatment in ovarian and aggressive brain cancers. This discovery enabled researchers to develop an algorithm to predict treatment effectiveness in individual patients. (Mehr in: Cancer News — ScienceDaily)

- Read more

Veranstaltungen

102. Jahrestagung der Deutschen Gesellschaft für Pathologie e.V.

23. Mai. 2018

Vom 24. bis 26. Mai 2018 tagt die Deutsche Gesellschaft für Pathologie e.V. (DGP) in Berlin zum 102. Mal. Auch in diesem Jahr sind die Beiträge auf der Tagung durch die bahnbrechenden Entwicklungen im Bereich der Molekularpathologie und den Einzug digitaler Techniken in den Arbeitsalltag der Pathologinnen und Pathologen geprägt. Dieser Trend hat auch im besonderen Maße Einfluss auf die Schwerpunkte des Kongresses: Tumorevolution und Tumorheterogenität sowie seltene Erkrankungen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

Das Babel-Projekt I – Epistemische Funktionen von Metaphern im wissenschaftlichen Erkenntnisprozess

02. Mai. 2018

Unsere Wahrnehmung der Welt und der wissenschaftliche Zugang zu ihrer kausalen Struktur sind wesentlich mit dem Gebrauch von Sprache – insbesondere Metaphern – verbunden. Metaphern erfüllen epistemische Funktionen, indem sie durch die Anlehnung an einen bekannten Quellbereich eine speziell geartete Vorstellung eines neuen, abstrakteren Konzeptes (Zielbereich) vermitteln. Sie sind somit auch für die Neukonstruktion und Artikulation von Theorien und Begriffen bedeutsam. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

89. Jahresversammlung der DGHNO KHC „Forschung heute – Zukunft morgen“

02. Mai. 2018

89. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V. (DGHNO KHC) „Forschung heute – Zukunft morgen“ Termin: Mittwoch, 9. Mai bis Samstag 12. Mai 2018 Ort: Musik- und Kongresshalle (MuK), Willy-Brandt-Allee 10, D-23554 Lübeck (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

7. Jahrestreffen der Seniorexperten Chemie

02. Mai. 2018

Seniorenchemiker in Weimar – Chemie zwischen Klassik und Moderne (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

02. Mai. 2018

Date: 15-18 May 2018 Location: Kloster Irsee (Bavaria, Germany)

There is growing interest from academia and industry in high-temperature shape memory alloys, as these represent a fascinating field both from a basic science and an application point of view. Recent literature demonstrates that substantial progress has been made since the first conference in 2015 exclusively devoted to this topic. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

12th COMPAMED Spring Convention

02. Mai. 2018

Implants in Medical Technology (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen

12. COMPAMED Frühjahrsforum

02. Mai. 2018

Implantate in der Medizintechnik (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

- Weiterlesen