Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Blocking gene expression to combat deadly fungal infection

Deadly fungal infections are becoming resistant to common treatments, but a team of researchers have found a potential new solution. (Mehr in: Cancer News — ScienceDaily)

Predictable genetic interactions

Researchers at IST Austria develop a model to predict how genetic interactions impact gene expression for the first time│ Study published in eLife (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Newly discovered DNA enhancers help switch on colorectal cancer

Genetic mutations can increase a person’s cancer risk, but other gene ‚enhancer‘ elements may also be responsible for disease progression, according to new research. In a breakthrough study, scientists discovered changes in specific regions of DNA, outside of colorectal cancer genes, that ‚enhance‘ harmful gene expression to help grow tumors. (Mehr in: Cancer News — ScienceDaily)

Powerful optical imaging technology catches DNA naturally fluorescing

Biomedical engineers have developed imaging technology that is the first to see DNA ‚blink,‘ or fluoresce. The tool enables researchers to study individual biomolecules (DNA, chromatin, proteins) as well as important global patterns of gene expression, which could yield insights into cancer. (Mehr in: Cancer News — ScienceDaily)

More patients with early-stage breast cancer may be able to avoid chemotherapy in the future

Women with early-stage breast cancer who had an intermediate risk recurrence score (RS) from a 21-gene expression assay had similar outcomes, regardless of whether they received chemotherapy, a new study has found. (Mehr in: Cancer News — ScienceDaily)

‚Mysterious‘ non-protein-coding RNAs play important roles in gene expression

Enhancers boost the rate of gene expression from nearby protein-coding genes so a cell can pump out more of a needed protein molecule. A mysterious subset of non-coding RNAs — enhancer RNAs (eRNAs) are transcribed from enhancer sequences. Shedding new light on these elusive eRNAs, researchers showed that CBP, an enzyme that activates transcription from enhancers, binds directly to eRNAs to control patterns of gene expression by acetylation. (Mehr in: Cancer News — ScienceDaily)

Overweight Affects DNA Methylation

The extra pounds you gain during the holidays will not only show up on your hips but will also affect your DNA. This is the result of a large-scale international study coordinated by Helmholtz Zentrum München, a partner in the German Center for Diabetes Research, which has now been published in ‘Nature’. The study shows that a high BMI leads to epigenetic changes at nearly 200 loci of the genome – with effects on gene expression. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Epigenetic change ties mitochondrial dysfunction to tumor progression

Scientists have identified a mechanism by which mitochondria can drive changes in nuclear gene expression that are associated with tumor progression. (Mehr in: Cancer News — ScienceDaily)

New advance in RNA studies holds out hope for cancer drug development

Scientists have designed a new method to find RNA structures linked to cancer. The formation of quadruplexes by RNA might allow new ways to control gene expression, they report. (Mehr in: Cancer News — ScienceDaily)

Epigenetics provides new insights into the pathogenesis of lymphoma

Cancer cells have a different DNA methylation pattern from that of healthy cells. These patterns can be used to explain tumor-specific deviations in gene expression and to identify biomarkers for the detection of tumors, as well as associated prognosis and treatment planning. This is all possible thanks to epigenetics. Epigenetics looks at special regulation mechanisms, such as DNA methylation and histone modifications, which determine the gene expression pattern of different types of cell and are passed on to daughter cells, without there being any specific changes to the DNA base sequence. Using this technology, it is now also possible to […]

Cancer news

Similarities between next-generation prostate cancer drugs discovered

22. Jun. 2017

For the first time, researchers have shown how a class of advanced prostate cancer drugs are processed in the body and how their anti-tumor activity might change depending on how they are metabolized. Their pre-clinical findings may lay the foundation for improving therapies for treatment-resistant, aggressive prostate cancer. (Mehr in: Cancer News — ScienceDaily)

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Better use of current drugs to target cancer

22. Jun. 2017

Researchers worked backwards, employing a series of drugs used in the clinic to understand a new way that cancer stem cells can be killed. (Mehr in: Cancer News — ScienceDaily)

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An enzyme to synthetize carbohydrates designed

22. Jun. 2017

Sugar or carbohydrate synthesis is important for the development of diagnostic tests, vaccines and new drugs. In a study, researchers have synthesized carbohydrates with enzymes through a reaction that was not much studied so far on these biomolecules and which creates few by-products. (Mehr in: Cancer News — ScienceDaily)

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Flipping the switch to stop tumor development

22. Jun. 2017

Researchers show how a protein prevents the uncontrolled expansion of immune cells, and have outlined their findings in a new report. (Mehr in: Cancer News — ScienceDaily)

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Secondhand smoke exposure among nonsmoking adult cancer survivors has declined

22. Jun. 2017

From 1999/2000 to 2011/2012, exposure to secondhand smoke among nonsmoking adult cancer survivors declined from 39.6 percent to 15.7 percent, but rates of exposure were higher among those with a history of a smoking-related cancer and those living below the federal poverty level compared with those with other types of cancer and those with the highest incomes, respectively. (Mehr in: Cancer News — ScienceDaily)

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First-line immunotherapy treatment can improve survival for subset of lung cancer patients

22. Jun. 2017

Findings from a phase III clinical trial for advanced lung cancer patients could help oncologists better predict which patients are likely to receive the most benefit from immunotherapy as a first-line treatment based on the unique molecular characteristics of their tumor, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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‚Rosetta Stone‘ to decode immune recognition

21. Jun. 2017

Medical researchers have developed an algorithm that predicts T cell recognition of antigens and sets the stage to more effectively harness the immune system. (Mehr in: Cancer News — ScienceDaily)

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Underused cancer test could improve treatment for thousands

21. Jun. 2017

A simple blood test could improve treatment for more than 1 in 6 stage 2 colon cancer patients, suggests new research. The researchers also discovered that many patients who could benefit from the test likely aren’t receiving it. (Mehr in: Cancer News — ScienceDaily)

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New antibody uses 1-2 punch to potentially treat blood cancers

21. Jun. 2017

Researchers have developed a two-pronged approach to blood cancer treatment: 1) attacking cancer cells directly and/or 2) driving them from the nurturing bone marrow environment into the peripheral blood streams, where they are more vulnerable (for example, to chemotherapy). (Mehr in: Cancer News — ScienceDaily)

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New inhibitor drug shows promise in relapsed leukemia

21. Jun. 2017

A new drug shows promise in its ability to target one of the most common and sinister mutations of acute myeloid leukemia (AML), according to researchers. In a first-in-human study, researchers treated relapsed patients with gilteritinib, an FLT3 inhibitor, and found it was a well-tolerated drug that led to frequent and more-sustained-than-expected clinical responses, almost exclusively in patients with this mutation. (Mehr in: Cancer News — ScienceDaily)

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New sensors could enable more affordable detection of pollution, diseases

21. Jun. 2017

When it comes to testing for cancer, environmental pollution and food contaminants, traditional sensors can help. The challenges are that they often are bulky, expensive, non-intuitive and complicated. Now, one team reports that portable pressure-based detectors coupled with smartphone software could provide a simpler, more affordable alternative while still maintaining sensitivity. (Mehr in: Cancer News — ScienceDaily)

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Finding the perfect match: New approach to battle drug-resistant bacteria

20. Jun. 2017

Antibiotics were the wonder drug of the 20th century, but bacteria evolved resistance. According to the CDC, more than 2 million people in the U.S. develop MDR infections every year. Researchers have now developed a rapid screen to pair existing FDA-approved drugs to combat MDR infections. (Mehr in: Cancer News — ScienceDaily)

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Family history and location of genetic fault affect risk for carriers of cancer genes

20. Jun. 2017

A large scale study of women carrying faults in important cancer genes should enable doctors to provide better advice and counselling for treatments and lifestyle changes aimed at reducing this risk. (Mehr in: Cancer News — ScienceDaily)

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Age-specific overall risk of breast, ovarian cancer among women with BRCA1/2 genetic mutations

20. Jun. 2017

Researchers conducted an analysis that included nearly 10,000 women with the BRCA1 or BRCA2 genetic mutations to estimate the age-specific risk of breast or ovarian cancer for women with these mutations, according to a study. (Mehr in: Cancer News — ScienceDaily)

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Brain tumors: Still devastating, but treatment has come a long way

20. Jun. 2017

A neurosurgeon discusses advances in brain tumor diagnosis and treatment that are bringing renewed hope to the battle against brain cancer. (Mehr in: Cancer News — ScienceDaily)

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How cells combat chromosome imbalance

20. Jun. 2017

Biologists have now identified a mechanism that the immune system uses to eliminate genetically imbalanced cells from the body. (Mehr in: Cancer News — ScienceDaily)

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Combining immunotherapies effective against mouse model of cancer

19. Jun. 2017

A recent study points to a new treatment strategy for rhabdomyosarcoma that takes advantage of the body’s own immune response. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

14. HepNet Symposium

02. Jun. 2017

Akkreditiert: mit 10 CME-Punkten von der Ärztekammer Niedersachsen mit 13 iCME-Punkten von der Akademie für Infektionsmedizin

Wissenschaftliche Leitung: Prof. Dr. med. Michael P. Manns, Hannover Prof. Dr. med. Stefan Zeuzem, Frankfurt Prof. Dr. med. Claus Niederau, Oberhausen Prof. Dr. med. Ulrike Protzer, München Prof. Dr. med. Peter Schirmacher, Heidelberg (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Art / Nature:Contemporary Art in Natural History Museums and Collections

02. Jun. 2017

A pilot project in cooperation with the German Federal Cultural Foundation.

The conference outlines recent and ongoing art projects and art programmes in natural history museums and in the natural history collections of multidisciplinary museums. In doing so, it aims to reflect upon and discuss the expectations, potentials, possible limitations and values of these kinds of interactions and interventions from the perspectives of curators, artists and researchers. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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8th Mildred Scheel Cancer Conference

02. Jun. 2017

Zum 8. Mal lädt die Deutsche Krebshilfe, gemeinsam mit der Deutschen Krebsgesellschaft, zur Mildred Scheel Cancer Conference ein. Vom 14.-16. Juni 2017 treffen sich renommierte Krebsexperten in Bonn, um über aktuelle Entwicklungen auf dem Gebiet der onkologischen Forschung zu diskutieren. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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8th International Triticeae Symposium 2017

02. Jun. 2017

This symposium includes four main themes:

Taxonomy, Phylogeny and Phytogeography Biodiversity and Conservation Genetics and Genomics Breeding and Utilization (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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8. Bayerischer Fachkongress Glücksspiel

02. Jun. 2017

Am 28. Juni 2017 findet der 8. Bayerische Fachkongress Glücksspiel im Novotel München City statt. Der Kongress läuft dieses Jahr unter dem Motto Migration – Trauma – Glücksspiel (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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7. HIPS Symposium on pharmaceutical sciences devoted to infection research

02. Jun. 2017

The HIPS symposium brings together renowed scientists and young investigators from three pharmaceutical communities: natural products, medicinal chemistry and drug delivery. It provides a forum for scientists to exchange ideas while crossing boundaries of classical disciplines. At the same time it gives young investigators the opportunity to obtain valuable feedback on their projects by international experts in the respective fields. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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3. Zukunftskongress "Technik zum Menschen bringen"

02. Jun. 2017

Der 3. Zukunftskongress „Technik zum Menschen bringen“ des Bundesministeriums für Bildung und Forschung findet vom 26. bis 27. Juni in Bonn (World Conference Center Bonn) statt. Diskutieren Sie mit uns gemeinsam neue Trends und informieren Sie sich über laufende und künftige Fördermaßnahmen des BMBF. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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