Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Optimizing technologies for discovering cancer cell mutations

Cancer cells often have mutations in their DNA that can give scientists clues about how the cancer started or which treatment may be most effective. Finding these mutations can be difficult, but a new method may offer more complete, comprehensive results. A team of researchers has developed a new framework that can combine three existing methods of finding these large mutations — or structural variants — into a single, more complete picture. (Mehr in: Cancer News — ScienceDaily)

Kidnapping in the Antarctic animal world?

A puzzling relationship between amphipods and pteropods (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

How our immune system detects broken DNA

Our immune system can detect when our own cells are damaged. This DNA damage can come from a variety of sources, such as the sun’s UV rays, chemical agents like cigarette smoke, or from genotoxic drugs used in chemotherapy. A new study found that DNA damage can lead to an immune response similar to that observed during viral infection. (Mehr in: Cancer News — ScienceDaily)

New clues found to understanding relapse in breast cancer

A large genomic analysis has linked certain DNA mutations to a high risk of relapse in estrogen receptor positive breast cancer, while other mutations were associated with better outcomes, according to researchers. (Mehr in: Cancer News — ScienceDaily)

Chromatinstruktur – Packen und entpacken

Im Zellkern ist das Erbgut dicht gewickelt. Trotzdem muss die Zelle immer wieder unterschiedliche Gene zugänglich machen. LMU-Forscher haben nun einen Mechanismus entschlüsselt, wie die molekularen Maschinen dabei DNA mit einem Zollstock aus Proteinen abmessen. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Breakthrough in understanding Warsaw breakage syndrome

Researchers have uncovered a previously unknown function of the DDX11 helicase enzyme. Mutations in the gene which codes for DDX11 are known to be implicated in Warsaw Breakage Syndrome. They showed that DDX11 plays an important role in DNA repair, and functions as a backup to the Fanconi Anemia (FA) pathway, whose malfunction is associated with another life-debilitating condition. (Mehr in: Cancer News — ScienceDaily)

More than just a DNA repair deficiency syndrome – impaired acetylation in Cockayne syndrome B

By studying the skin phenotype of the hereditary disease Cockayne syndrome researchers at the IUF and HHU Düsseldorf have found a mechanism which can prevent the loss of subcutaneous fat, i.e. one of the cardinal symptoms of Cockayne syndrome. This study was now published in “Science Translational Medicine”. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Precise, Highly Efficient Gene Repair

The molecular tool CRISPR/Cas allows introducing DNA double strand breaks into any gene of interest consequently resulting in stochastic mutations at the site of the target gene. However, precise gene repair through the application of a rescue construct suffers from limited efficiency. Researchers at Heidelberg University have now found a solution for this problem. Applying their new approach on the model organism medaka, the researchers laid the groundwork for easily integrating the repair copy of a defective gene into the DNA. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Präzise Genreparatur mit hoher Effizienz

Mit der molekulargenetischen Methode CRISPR/Cas können Brüche im Doppelstrang der DNA und damit zufällige Mutationen in jedem Zielgen herbeigeführt werden. Die exakte Reparatur eines Gens mithilfe einer Reparaturkopie ist jedoch nur außerordentlich aufwendig möglich. Dafür haben Forscher der Universität Heidelberg eine Lösung gefunden: Mit der Anwendung eines neuen Ansatzes am Modellorganismus Medaka haben sie die Grundlage geschaffen, um auf einfache Weise die Reparaturkopie eines defekten Gens in die DNA einzuschleusen. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

A bucket full of genes: pond water reveals tropical frogs

Frankfurt am Main, 08/29/2018. When a frog jumps into a pond, it inevitably leaves behind traces of its genetic material. Using water samples from the Bolivian lowlands, Senckenberg scientists were now able to demonstrate that the analysis of this so-called environmental DNA allows the reliable identification of the frog species that inhabit a body of water. In their feasibility study, the researchers show that the analysis of environmental DNA can serve as a cost-effective alternative to traditional survey methods in species-rich regions and may speed up the necessary world-wide inventory of biological diversity. The study has just been published in […]

Cancer news

Tweaking cells‘ gatekeepers could lead to new way to fight cancer

19. Sep. 2018

Researchers have devised a way to manipulate numbers of individual nuclear pores — a breakthrough that may one day stop cancerous cells from proliferating out of control. (Mehr in: Cancer News — ScienceDaily)

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New hurdle for developing immunotherapies

18. Sep. 2018

A new discovery tosses a new wrench into the process of building better molecules to develop immunotherapies. (Mehr in: Cancer News — ScienceDaily)

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Eating foods with low nutritional quality ratings linked to cancer risk in large European cohort

18. Sep. 2018

The consumption of foods with higher scores on the British Food Standards Agency nutrient profiling system (FSAm-NPS), reflecting a lower nutritional quality, is associated with an increased risk of developing cancer. (Mehr in: Cancer News — ScienceDaily)

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How cells repurpose their garbage disposal systems to promote inflammation

18. Sep. 2018

Researchers have unraveled new insights into the way cells leverage G-protein-coupled receptors (GPCRs) and their cellular waste disposal systems to control inflammation. The findings suggest some existing cancer drugs that inhibit these cellular activities might be repurposed to treat vascular inflammation, which occurs when artery-blocking plaques form in atherosclerosis. (Mehr in: Cancer News — ScienceDaily)

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CRISPR screen reveals new targets in more than half of all squamous cell carcinomas

18. Sep. 2018

Researchers sheds light on p63 activity in squamous cell carcinoma of the lung, providing an actionable path forward to drug development against this known cause of cancer. (Mehr in: Cancer News — ScienceDaily)

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Chemists create circular fluorescent dyes for biological imaging

18. Sep. 2018

Chemists have created a new class of fluorescent dyes that function in water and emit colors based solely on the diameter of circular nanotubes made of carbon and hydrogen. (Mehr in: Cancer News — ScienceDaily)

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Colon cancer is caused by bacteria and cell stress

18. Sep. 2018

Scientists have made an unexpected discovery while investigating the triggering factors of colon cancer: Cell stress in combination with an altered microbiota in the colon drives tumor growth. Previously, it was assumed that this combination only contributes to inflammatory intestinal diseases. (Mehr in: Cancer News — ScienceDaily)

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Better chemo drug adsorption onto targeted delivery capsules

18. Sep. 2018

One of the challenges in cancer research is improving the delivery of chemo drugs to enhance their efficacy while decreasing the risk of side effects. Scientists now perform a theoretical prediction of adsorption of a well-known chemo drug onto active carbon with aluminium inclusions, to show its potential as an oral chemotherapy delivery capsule. (Mehr in: Cancer News — ScienceDaily)

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Zika vaccine shows promise for treating deadly brain cancer

18. Sep. 2018

Researchers have successfully deployed a Zika virus vaccine to target and kill human glioblastoma brain cancer stem cells, which had been transplanted into mice. In a new study, the team shows that a live, attenuated version of the Zika virus could form the basis of a new treatment option for this fatal brain cancer. (Mehr in: Cancer News — ScienceDaily)

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Silicone breast implants linked to increased risk of some rare harms

18. Sep. 2018

Women receiving silicone breast implants may be at increased risk of several rare adverse outcomes compared to the general population. (Mehr in: Cancer News — ScienceDaily)

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Artificial intelligence can determine lung cancer type

17. Sep. 2018

A new computer program can analyze images of patients‘ lung tumors, specify cancer types, and even identify altered genes driving abnormal cell growth, a new study shows. (Mehr in: Cancer News — ScienceDaily)

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Developmental stage for No. 1 eye tumor in children

17. Sep. 2018

Investigators have been able to pinpoint the exact stage of development of the human retina, when cells can grow out of control and form cancer-like masses. The finding could open the door for future interventions in retinoblastoma (RB), a tumor of the retina that affects children under five years of age. (Mehr in: Cancer News — ScienceDaily)

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New blood test detects early stage pancreatic cancer

17. Sep. 2018

Pancreatic cancer is currently very difficult to detect while it is still resectable. A new blood test can detect pancreatic cancer in the very earliest stages of the disease. (Mehr in: Cancer News — ScienceDaily)

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Daily low-dose aspirin found to have no effect on healthy life span in older people

16. Sep. 2018

In a clinical trial to determine the effects of daily low-dose aspirin in healthy older adults without previous cardiovascular events, aspirin did not prolong healthy, independent living free of dementia or physical disability. (Mehr in: Cancer News — ScienceDaily)

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Research in yeast leads to serendipitous finding about a central nervous system disorder

14. Sep. 2018

Researchers found that an important quality control mechanism in baker’s yeast is closely connected to hypomyelinating leukodystrophy, a debilitating disease found in children. The findings could indicate a therapeutic approach for this rare disease, as well as for multiple sclerosis and other neurodegenerative diseases. (Mehr in: Cancer News — ScienceDaily)

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New method promises fewer side effects from cancer drugs

14. Sep. 2018

A recent achievement in the field of protein research allows for better tailored pharmaceuticals with fewer side effects. (Mehr in: Cancer News — ScienceDaily)

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Cancer drug and antidepressants provide clues for treating brain-eating amoeba infections

13. Sep. 2018

Researchers have now identified three new molecular drug targets in Naegleria fowleri and a number of drugs that are able to inhibit the amoeba’s growth in a laboratory dish. Several of these drugs are already approved by the US Food and Drug Administration for other uses, such as antifungal agents, the breast cancer drug tamoxifen and antidepressant Prozac. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

11. Bundesalgenstammtisch 2018; Mikroalgen für Umwelt und Wertschöpfung

01. Sep. 2018

Der jährlich stattfindende „Bundesalgenstammtisch“ ist die deutschsprachige Kommunikationsplattform für alle, die mit der Algenbiotechnologie in Wissenschaft und Industrie befasst sind. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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4th Forum on Hydrothermal Processes "Technologies generating material and energetic added value"

01. Sep. 2018

The event will be bilingual – German and English with simultaneous translation. Presentations and posters will be available in both languages. If you are interested in participating in the event with a presentation/talk or poster, please submit your Application form by May 1st, 2018 via e-mail to htp-inno@dbfz.de.

Accepted abstracts will appear in the conference reader. For accepted posters, a short introduction (three minutes, one slide) will be provided in addition to the poster exhibiton. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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4. Tag der Arbeitsmedizin in Hannover

01. Sep. 2018

Dialogforen Arbeitsmedizin und Arbeitssicherheit – Eine Veranstaltungsreihe für Wissenschaft und Praxis der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. (DGAUM) und RG GmbH (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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3rd European Conference on Natural Products

01. Sep. 2018

The 3rd European Conference on Natural Products will again feature recent advances in secondary metabolite research. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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18. Wissenschaftliche Jahrestagung der DGSF

01. Sep. 2018

Ich, Du und die anderen … Selbstorganisation – Selbststeuerung und die Frage nach dem Sinn

18. Wissenschaftliche Jahrestagung der DGSF vom 20.- 22. September 2018 an der Universität Oldenburg (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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18. Scientific Meeting (ScieM)

01. Sep. 2018

Am 27. und 28. September 2018 findet das 18. Scientific Meeting (ScieM) des Mukoviszidose e.V. in Bad Salzschlirf statt. Thema des diesjährigen Meetings sind „Anti-inflammatorische Therapien im Kontext des Mikrobioms in Lunge und Darm“. Mukoviszidose-Forscherinnen und -Forscher aus der ganzen Welt sind dazu eingeladen, beim Meeting über dieses zurzeit sehr relevante Forschungsthema zu diskutieren. Abstracts für Vorträge können bis zum 15. Juni 2018 eingereicht werden. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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17. Tag der Arbeitsmedizin in Berlin

01. Sep. 2018

Dialogforen Arbeitsmedizin und Arbeitssicherheit – Eine Veranstaltungsreihe für Wissenschaft und Praxis der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. (DGAUM) und RG GmbH (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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