New imaging tools that trace key breast cancer enzymes may help guide therapies

A set of emerging diagnostic tools may help identify breast cancer patients who are most likely to benefit from therapies that target important enzymes fueling a range of subtypes, including BCRA-mutated and triple negative cancers. (Mehr in: Cancer News — ScienceDaily)

New therapeutic opportunity for the treatment of resistant malignant melanoma

Researchers have revealed that malignant melanoma can reprogram their protein synthesis machinery and become addicted to a new family of enzymes that modify transfer RNAs during acquired resistance. The inhibition of these molecules synergies with targeted therapies to produce a strong anti-tumoral effect. These new findings will be key in the development of improved diagnostic tools and melanoma treatment. (Mehr in: Cancer News — ScienceDaily)

CRISPR-based diagnostic tool advanced, miniature paper test developed

The team that first unveiled the rapid, inexpensive, highly sensitive CRISPR-based diagnostic tool called SHERLOCK has greatly enhanced the tool’s power to work with a miniature paper test, similar to a pregnancy test, allowing rapid and simple detection in any setting. Additional features greatly expand both the breadth and sensitivity of the diagnostic information, including the ability to detect multiple targets at once and quantify the amount of target in a sample. (Mehr in: Cancer News — ScienceDaily)

New Diagnostic Tool Aids Quality Control in Xenotransplantations

HZI and HIPS researchers discover a bacterial protein that recognises immunogenic sugar molecules on pig cells (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

New crispr-based diagnostic platform unveiled

A team of scientists has adapted a CRISPR protein that targets RNA (rather than DNA) as a rapid, inexpensive, highly sensitive diagnostic tool with the potential for a transformative effect on research and global public health. (Mehr in: Cancer News — ScienceDaily)

Light scattering spectroscopy helps doctors identify early pancreatic cancer

Pancreatic cancer has the lowest survival rate among all major cancers, largely because physicians lack diagnostic tools to detect the disease in its early, treatable stages. Now, a team of investigators has developed a promising new tool capable of distinguishing between harmless pancreatic cysts and those with malignant potential with an overall accuracy of 95 percent. (Mehr in: Cancer News — ScienceDaily)

New class of materials could revolutionize biomedical, alternative energy industries

Polyhedral boranes, or clusters of boron atoms bound to hydrogen atoms, are transforming the biomedical industry. These humanmade materials have become the basis for the creation of cancer therapies, enhanced drug delivery and new contrast agents needed for radioimaging and diagnosis. Now, a researcher has discovered an entirely new class of materials based on boranes that might have widespread potential applications, including improved diagnostic tools for cancer and other diseases as well as low-cost solar energy cells. (Mehr in: Cancer News — ScienceDaily)

New images of a calcium-shuttling molecule that has been linked to aggressive cancer

Scientists have captured new images of a calcium-shuttling molecule that has been linked to aggressive cancers. The three-dimensional structure could help researchers develop novel therapies and diagnostic tools for diseases that are caused by a malfunction in calcium adsorption. (Mehr in: Cancer News — ScienceDaily)

Breakthrough in diagnosis of melanoma skin cancer

Researchers have revealed a remarkable link between malignant melanoma and a non-coding RNA gene called SAMMSON. The SAMMSON gene is expressed in human malignant melanoma and, strikingly, the growth of aggressive skin cancer is highly dependent on this gene. The conclusions could pave the way for improved diagnostic tools and skin cancer treatment. (Mehr in: Cancer News — ScienceDaily)

Novel diagnostic tool for ethnically diverse non-small-cell lung cancer patients

Early-stage Non-small-cell Lung Cancer is asymptomatic and difficult to detect since no blood test for NSCLC is currently available. In a new study, researchers identified a panel of five serum microRNAs as the potential biomarker for NSCLC diagnosis. (Mehr in: Cancer News — ScienceDaily)

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection.

Warburg O, Posener K, Negelein E. (1924) Über den Stoffwechsel der Carcinomzelle. Biochem Z. 152, 309–344.