Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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How protein interactions drive cellular death

Researchers use a simplified model of a protein network to explain how apoptosis is regulated, whose malfunction is linked to cancer and neurodegenerative diseases. (Mehr in: Cancer News — ScienceDaily)

Disease-busting ‚recycling bins‘ in our cells now better understood

Scientists have made an important step in understanding how cells keep themselves clean and healthy — a finding that may have implications for combating neurodegenerative diseases and cancer. (Mehr in: Cancer News — ScienceDaily)

Overactive Scavenger Cells May Cause Neurodegeneration in Alzheimer’s

For the first time, researchers at the University of Zurich have demonstrated a surprising effect of microglia, the scavenger cells of the brain: If these cells lack the TDP-43 protein, they not only remove Alzheimer’s plaques, but also synapses. This removal of synapses by these cells presumably lead to neurodegeneration observed in Alzheimer’s and other neurodegenerative diseases. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

CRTD receives 1.56 Mill. Euro BMBF-funding for retinal disease research

The research groups lead by Prof. Dr. Elly Tanaka, Prof. Dr. Marius Ader and Dr. Mike Karl at the DFG-Research Center for Regenerative Therapies Dresden (CRTD) – Cluster of Excellence at TU Dresden, have received funding in the BMBF program “Validation of the technological and societal innovation potential of scientific research – VIP+” with their CLEANSIGHT research team. The research project will focus on validating a retinal cell–based screening platform for fast and efficient identification of small molecules for the treatment of retinal degenerative diseases. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Unravelling the mystery of DNA attacks in cells‘ powerhouse could pave way for new cancer treatments

A five-year study has found the mechanism responsible for repairing damage to mitochondrial DNA. This discovery could pave the way for new treatments for cancer and neurodegenerative diseases, say the researchers. This research may also have important implications for clinical advances in so called ‘three-parent baby’ mitochondrial donation. (Mehr in: Cancer News — ScienceDaily)

Combating iron in the brain: Researchers find anti-aging micromolecule

The older we get, the more our brain ages. Cognitive abilities decline and the risk of developing neurodegenerative diseases like dementia, Alzheimer’s and Parkinson’s disease or having a stroke steadily increases. A possible cause is the accumulation of iron molecules within neurons, which seems to be valid for all vertebrates. In a collaborative research project, scientists found that this iron accumulation is linked to a microRNA called miR-29. (Mehr in: Cancer News — ScienceDaily)

Neurons modulate the growth of blood vessels

A team of researchers shake at the foundations of a dogma of cell biology. By detailed series of experiments, they proved that blood vessel growth is modulated by neurons and not, as assumed so far, through a control mechanism of the vessel cells among each other. The results are groundbreaking for research into and treatment of vascular diseases, tumors, and neurodegenerative diseases. (Mehr in: Cancer News — ScienceDaily)

Process cells use to destroy damaged organelles now identified

Researchers have uncovered the mechanism that cells use to find and destroy an organelle called mitochondria that, when damaged, may lead to genetic problems, cancer, neurodegenerative diseases, inflammatory disease, and aging. (Mehr in: Cancer News — ScienceDaily)

Rejuvenating the brain’s disposal system

Heidelberg, 21 December 2016 – A characteristic feature of Alzheimer’s disease is the presence of so called amyloid plaques in the patient’s brain – aggregates of misfolded proteins that clump together and damage nerve cells. Researchers from the German Center for Neurodegenerative Diseases (DZNE), Munich and the Ludwig Maximilians University (LMU) Munich have now discovered a strategy to help the brain remove amyloid plaques. The work is published today in The EMBO Journal. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Cancer research: How cells die by ferroptosis

Ferroptosis is a recently discovered form of cell death, which is still only partially understood. Scientists have now identified an enzyme that plays a key role in generating the signal that initiates cell death. Their findings could now give new impetus to research into the fields of cancer, neurodegeneration and other degenerative diseases. (Mehr in: Cancer News — ScienceDaily)

Cancer news

Study of California kidney cancer shows declining incidence, end of a trend

18. Aug. 2017

A study of kidney cancer incidence in California over 25 years is the first report to demonstrate that the rising rate of kidney cancer seen in the US over the past two decades may have ended. (Mehr in: Cancer News — ScienceDaily)

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Histone 1, the guardian of genome stability

18. Aug. 2017

Genomic instability is the main risk factor for tumor development in humans. Therefore understanding its origin and and exploring therapeutic targets is paramount. Histone 1 silences a region of the genome that causes irreparable DNA damage when translated and is lethal for the organism. (Mehr in: Cancer News — ScienceDaily)

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A better way to measure mortality trends?

17. Aug. 2017

A new study suggests long-term mortality trends may be better understood by focusing on life-years lost — remaining life expectancy for a decedent — instead of solely looking at cause of death. (Mehr in: Cancer News — ScienceDaily)

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Gold nanostars and immunotherapy vaccinate mice against cancer

17. Aug. 2017

By combining an FDA-approved cancer immunotherapy with an emerging tumor-roasting nanotechnology, researchers improved the efficacy of both therapies in a proof-of-concept study using mice. The potent combination also attacked satellite tumors and distant cancerous cells, completely curing two mice and effectively vaccinating one against the disease. (Mehr in: Cancer News — ScienceDaily)

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New terahertz imaging approach could speed up skin cancer detection

17. Aug. 2017

Researchers have developed a new terahertz imaging approach that, for the first time, can acquire micron-scale resolution images while retaining computational approaches designed to speed up image acquisition. (Mehr in: Cancer News — ScienceDaily)

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New Pathology Atlas maps genes in cancer to accelerate progress in personalized medicine

17. Aug. 2017

A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns of individual cancers observed in the study strongly reinforces the need for personalized cancer treatment based on precision medicine. (Mehr in: Cancer News — ScienceDaily)

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Scientists develop novel immunotherapy technology for prostate cancer

17. Aug. 2017

A novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer-specific protein has been described in a new article. (Mehr in: Cancer News — ScienceDaily)

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Are stem cells the link between bacteria and cancer?

17. Aug. 2017

A new mechanism of stomach gland regeneration reveals impact of Helicobacter pylori infection. (Mehr in: Cancer News — ScienceDaily)

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Energy dense foods may increase cancer risk regardless of obesity status

17. Aug. 2017

While there is a proven link between obesity and certain types of cancer, less is known about how the ratio of energy to food weight, otherwise known as dietary energy density (DED), contributes to cancer risk. To find out, researchers looked at DED in the diets of post-menopausal women and discovered that consuming high DED foods was tied to a 10 percent increase in obesity-related cancer among normal weight women. (Mehr in: Cancer News — ScienceDaily)

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New strategy to treat aggressive lung cancer

16. Aug. 2017

Research on a novel therapeutic avenue for an aggressive and difficult to treat subgroup of lung cancer has now been shared in a new article. (Mehr in: Cancer News — ScienceDaily)

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Problems with DNA replication can cause epigenetic changes that may be inherited for several generations

16. Aug. 2017

Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to five generations. They also identified the cause of these epigenetic changes, which is related to the loss of a molecular mechanism in charge of silencing genes. Their results will change the way we think about the impact of replication stress in cancer and during embryonic development, as well as its inter-generational inheritance. (Mehr in: Cancer News — ScienceDaily)

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Popular immunotherapy target turns out to have a surprising buddy

16. Aug. 2017

The majority of current cancer immunotherapies focus on PD-L1. This well-studied protein turns out to be controlled by a partner, CMTM6, a previously unexplored molecule that is now suddenly also a potential therapeutic target. (Mehr in: Cancer News — ScienceDaily)

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Toxic formaldehyde is produced inside our own cells, scientists discover

16. Aug. 2017

New research has revealed that some of the toxin formaldehyde in our bodies does not come from our environment — it is a by-product of an essential reaction inside our own cells. This could provide new targets for developing cancer therapies. (Mehr in: Cancer News — ScienceDaily)

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Multicolor MRIs could aid disease detection

16. Aug. 2017

Researchers have developed a method that could make magnetic resonance imaging — MRI — multicolor. Current MRI techniques rely on a single contrast agent injected into a patient’s veins to vivify images. The new method uses two at once, which could allow doctors to map multiple characteristics of a patient’s internal organs in a single MRI. The strategy could serve as a research tool and even aid disease diagnosis. (Mehr in: Cancer News — ScienceDaily)

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Estrogen receptor stem cells found in mammary glands

16. Aug. 2017

One of the key questions in stem cell and cancer biology is to understand the cellular hierarchy governing tissue development and maintenance and the cancer cell of origin. Researchers have now identified a novel lineage – restricted stem cell in the mammary gland. In the future, this model will be used to assess whether the clinical heterogeneity observed in breast cancers arises from their different cancer cell of origin. (Mehr in: Cancer News — ScienceDaily)

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Combination of traditional chemotherapy, new drug kills rare cancer cells in mice

16. Aug. 2017

An experimental drug combined with the traditional chemotherapy drug cisplatin, when used in mice, destroyed a rare form of salivary gland tumor and prevented a recurrence within 300 days, a study found. (Mehr in: Cancer News — ScienceDaily)

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How decision-making habits influence the breast cancer treatments women consider

15. Aug. 2017

A new study finds that more than half of women with early stage breast cancer considered an aggressive type of surgery to remove both breasts. The way women generally approach big decisions, combined with their values, impacts what breast cancer treatment they consider, the study also found. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

25. Wiss. Symposium für Psychotherapie: Veränderbarkeit – Ändern/Verändern/Anders am 13./14.10.2017

12. Aug. 2017

1992 wurde das Wissenschaftliche Symposium für Psychotherapie eingeführt. 25 Jahre später lädt die LWL-Universitätsklinik Bochum für Psychosomatische Medizin und Psychotherapie zu einem Jubiläumssymposium ein. Was hat sich verändert und welche Entwicklungen sind zu erwarten? Psychotherapie will ändern und stellt sich der Frage nach der Veränderbarkeit eines Menschen. Die Vorträge reichen von (epi)genetischen über soziologische, kulturelle bis hin zu psychotherapeutischen Themen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Bavarian Summer School 2017 – The Future of Health Care

24. Jul. 2017

From 24/07/ until 04/08/17 the first summer school organized by Study & Work International, an initiative of the Bavarian Association of Universities of Applied Sciences (UAS), takes place at the Lutheran UAS Nuremberg and the technical UAS OTH Amberg-Weiden.The Future of Health Care: New Concepts – New Technologies is the topic of this two-week interdisciplinary summer school for Bachelor’s students from the fields of health care as well as various engineering disciplines (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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15th EUROPEAN CONFERENCE ON ORGANIZED FILMS

08. Jul. 2017

The 15th European Conference on Organized Films (ECOF 15) adds to a successful series of conferences addressing latest findings and advances in the field of thin and ultrathin organic films as well as nanoscience and -technologies. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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14th Dortmund MST Conference – Individualized Healthcare Solutions

05. Jul. 2017

Embracing „Individualized Healthcare Solutions“, the 14th Dortmund MST Conference on July 5, 2017 will present microsystems, production processes and digital technologies for use in medical technology and healthcare. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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14. Dortmunder MST-Konferenz – Individualisierte Gesundheitslösungen

05. Jul. 2017

Unter dem Motto „Individualisierte Gesundheitslösungen“ präsentiert die 14. Dortmunder MST-Konferenz am 5. Juli 2017 Mikrosysteme, mikrotechnische Fertigungsverfahren und digitale Technologien für den Einsatz in der Medizintechnik und Gesundheitsversorgung. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Art / Nature:Contemporary Art in Natural History Museums and Collections

02. Jun. 2017

A pilot project in cooperation with the German Federal Cultural Foundation.

The conference outlines recent and ongoing art projects and art programmes in natural history museums and in the natural history collections of multidisciplinary museums. In doing so, it aims to reflect upon and discuss the expectations, potentials, possible limitations and values of these kinds of interactions and interventions from the perspectives of curators, artists and researchers. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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8th Mildred Scheel Cancer Conference

02. Jun. 2017

Zum 8. Mal lädt die Deutsche Krebshilfe, gemeinsam mit der Deutschen Krebsgesellschaft, zur Mildred Scheel Cancer Conference ein. Vom 14.-16. Juni 2017 treffen sich renommierte Krebsexperten in Bonn, um über aktuelle Entwicklungen auf dem Gebiet der onkologischen Forschung zu diskutieren. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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