A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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The role of ‚extra‘ DNA in cancer evolution and therapy resistance

Researchers tracked genomic alterations detected in patient samples during tumor cell evolution in culture, in patient-derived xenograft (PDX) mouse models from the cultures, as well as before and after treatment in patients. The team reports that tumor progression was often driven by cancer-promoting genes, known as oncogenes, on extrachromosomal pieces of DNA. (Mehr in: Cancer News — ScienceDaily)

Faltkunst im Zellkern

Strukturelle Chromosomen-Mutationen können die Faltung der DNA im Zellkern beeinflussen und zu einer Fehlregulation von Genen führen. Wissenschaftler/innen des Max-Planck-Instituts für molekulare Genetik (MPIMG) in Berlin haben gemeinsam mit Physiker/innen der Universität Neapel Verfahren für Vorhersagen entwickelt, ob und wie solche Struktur-Varianten die dreidimensionale Faltung der Chromosomen verändern. Damit wollen die Forscher/innen herausfinden, ob bestimmte Mutationen die Genregulation beeinflussen und so Krankheiten verursachen können. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Folding art in the nucleus

Structural variants can influence the folding of DNA in the nucleus and thus lead to a misregulation of genes. Now, scientists at the Max Planck Institute for Molecular Genetics (MPIMG) in Berlin together with physicists of the University of Naples, Italy, have developed methods to predict, whether and how such structural variants might alter the three-dimensional folding of the chromosomes. With these methods, the researchers want to predict if specific mutations influence gene regulation and can cause diseases. Their long-term goal is to better understand the so far puzzling causes of congenital malformations in order to improve the diagnosis of […]

„AGameOfClones“ unterscheidet transgene Organismen

Forscher der Goethe-Universität können mithilfe leuchtender Marker einfach und zuverlässig unterscheiden, ob transgene Organismen das fremde Gen auf einem oder auf beiden Chromosomen tragen. Dies erleichtert die Zucht und kommt dem Tierschutz zugute. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Wechselkröten zeigen: Arten mit vielfachen Genomen haben lediglich entfernt verwandte Vorfahren

Die meisten Wirbeltiere haben zwei Chromosomensätze, einen von der Mutter und einen vom Vater – auch wir Menschen sind diploid. Viel seltener ist die Polyploidie, also der Besitz von drei oder mehr Chromosomensätzen. Um die Entstehung neuer Wirbeltierarten zu erforschen, studieren EvolutionsbiologInnen Wechselkröten – diese können diploid oder polyploid sein. Dr. Matthias Stöck vom Leibniz-Institut für Gewässerökologie und Binnenfischerei und ForscherInnen der Universität Lausanne und des Helmholtz-Zentrums für Umweltforschung haben einen Stammbaum für die eurasischen Wechselkrötenarten vorgelegt: Die polyploiden Arten stammen von Elternlinien mit sehr geringem Verwandtschaftsgrad ab. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Studying mitosis‘ structure to understand the inside of cancer cells

Cell division is an intricately choreographed ballet of proteins and molecules that divide the cell. During mitosis, microtubule-organizing centers assemble the spindle fibers that separate the copying chromosomes of DNA. While scientists are familiar with MTOCs‘ existence and the role they play in cell division, their actual physical structure remains poorly understood. Researchers are now trying to decipher their molecular architecture. (Mehr in: Cancer News — ScienceDaily)

New mutation linked to ovarian cancer can be passed down through dad

A newly identified mutation, passed down through the X-chromosome, is linked to earlier onset of ovarian cancer in women and prostate cancer in father and sons. (Mehr in: Cancer News — ScienceDaily)

Moos verdoppelte mehrmals sein Genom

Endlich komplett! Zehn Jahre, nachdem ein Forschungsverbund das Genom des Kleinen Blasenmützenmooses entschlüsselte, haben die Wissenschaftlerinnen und Wissenschaftler nunmehr die verbliebenen Lücken geschlossen. Das Team berichtet im Fachblatt „The Plant Journal“ über die Ergebnisse; sie zeigen erstmals die Chromosomenarchitektur von samenlosen Pflanzen. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Important new aspects are revealed about the control of cell division

Experts have published a new study on the mechanisms that regulate cell division and guarantee the correct distribution of chromosomes during this process. In particular, they especially highlight the fundamental role that an organelle, specifically the nucleolus, plays in the coordination of these processes. (Mehr in: Cancer News — ScienceDaily)

Genome of Leishmania reveals how this parasite adapts to environmental changes

Scientists demonstrate that Leishmania adaptation results from frequent and reversible chromosomal amplifications. This novel insight into Leishmania genomic instability should pave the way for the identification of parasite drug resistance mechanisms and help discover biomarkers. (Mehr in: Cancer News — ScienceDaily)

Cancer news

Experimental arthritis drug prevents stem cell transplant complication

25. Apr. 2018

An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research shows. Studying mice, the researchers found the drug prevented what’s known as graft-versus-host disease, a debilitating, sometimes lethal condition that develops when transplanted stem cells attack the body’s own organs or tissues. (Mehr in: Cancer News — ScienceDaily)

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Doctors may soon be able to see a brain tumor burned away in real time

24. Apr. 2018

A team of researchers are now making it easier, faster and safer for doctors to use an emerging procedure — one that involves burning away tumors in more patients, including those with brain tumors. (Mehr in: Cancer News — ScienceDaily)

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Organoids reveal how a deadly brain cancer grows

24. Apr. 2018

Scientists developed a new model for glioblastoma using gene-edited organoids. (Mehr in: Cancer News — ScienceDaily)

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Technology used to map Mars now measuring effect of treatment on tumors

24. Apr. 2018

A machine learning approach for assessing images of the craters and dunes of Mars has now been adapted to help scientists measure the effects of treatments on tumors. (Mehr in: Cancer News — ScienceDaily)

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A non-coding RNA lasso catches proteins in breast cancer cells

24. Apr. 2018

A Danish-German research team has shown that not only the where and when of long non-coding RNA expression is important for their function but also the how. The results can have a big impact on our understanding of dynamic regulation of gene expression in biological processes. (Mehr in: Cancer News — ScienceDaily)

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Scientists unearth vital link between fat, immunity and heat regulation

24. Apr. 2018

Scientists have discovered a key, previously unknown role for a population of cells that live in our fat — these cells regulate our body heat and protect us against cold shock. The discovery opens the door to future treatments in which weight loss (or gain) is the desired goal, as activating the pathway involved may stimulate the body to burn (or not burn) white fat. (Mehr in: Cancer News — ScienceDaily)

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Hemp shows potential for treating ovarian cancer

23. Apr. 2018

Results from some of the first studies to examine hemp’s ability to fight cancer show that it might one day be useful as plant-based treatment for ovarian cancer. Hemp is part of the same cannabis family as marijuana but doesn’t have any psychoactive properties or cause addiction. (Mehr in: Cancer News — ScienceDaily)

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Scientists generate an atlas of the human genome using stem cells

23. Apr. 2018

Scientists have generated an atlas of the human genome that illuminates the roles our genes play in health and disease. The gene atlas, created using a state-of-the-art gene editing technology and human embryonic stem cells, enables a new functional view on how we study the human genome, and provides a tool that will change how we study and treat cancer and genetic disorders. (Mehr in: Cancer News — ScienceDaily)

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The role of ‚extra‘ DNA in cancer evolution and therapy resistance

23. Apr. 2018

Researchers tracked genomic alterations detected in patient samples during tumor cell evolution in culture, in patient-derived xenograft (PDX) mouse models from the cultures, as well as before and after treatment in patients. The team reports that tumor progression was often driven by cancer-promoting genes, known as oncogenes, on extrachromosomal pieces of DNA. (Mehr in: Cancer News — ScienceDaily)

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Size, structure help poziotinib pose threat to deadly exon 20 lung cancer

23. Apr. 2018

A drug that failed to effectively strike larger targets in lung cancer hits a bulls-eye on the smaller target presented by a previously untreatable form of the disease. (Mehr in: Cancer News — ScienceDaily)

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Odd one out: Protein goes against the family to prevent cancer

23. Apr. 2018

Researchers have made the surprise discovery that the ‚odd one out‘ in a family of proteins known to drive cancer development is instead critical for preventing stomach cancers. The research team showed switching off a certain gene caused spontaneous development of stomach cancers, driven by chronic inflammation. The study also revealed that immunotherapy may prove to be a significant tool for treating stomach cancers that are driven by runaway inflammation, warranting further investigation. (Mehr in: Cancer News — ScienceDaily)

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E. coli’s internal bomb may provide novel target for treatment strategy

21. Apr. 2018

Bacteria’s internal bomb, the so-called toxin-antitoxin (TA) system that is part of the normal bacterial makeup, may be triggered to make bacteria turn on themselves, providing a valuable target for novel antimicrobial approaches in drug design, according to new research. (Mehr in: Cancer News — ScienceDaily)

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Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells

20. Apr. 2018

Cancer immune cell therapy has made headlines with astounding successes like saving former US President Jimmy Carter from brain cancer. But immunotherapy has also had many tragic flops. Researchers working to optimize the innovative treatment have implanted a genetic switch that activates T-cells when they are inside of tumors. Remote-control light waves resembling those used in a TV remote combine with gold nanorods to flip the switch. (Mehr in: Cancer News — ScienceDaily)

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Treatment of cancer could become possible with adenovirus

20. Apr. 2018

Researchers have shown that adenovirus binds to a specific type of carbohydrate that is overexpressed on certain types of cancer cells. The discovery opens up new opportunities for the development of virus-based cancer therapy. (Mehr in: Cancer News — ScienceDaily)

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Soil metals linked with cancer mortality

20. Apr. 2018

Epidemiologists and geologists have found associations between esophageal cancer and soils where lead is abundant, lung cancer and terrains with increased copper content, brain tumor with areas rich in arsenic, and bladder cancer with high cadmium levels. These statistical links do not indicate that there is a cause-effect relationship between soil type and cancer, but they suggest that the influence of metals from the earth’s surface on the geographical distribution of tumors should be analyzed. (Mehr in: Cancer News — ScienceDaily)

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Vitamin D deficiency linked to greater risk of diabetes

19. Apr. 2018

An epidemiological study suggests that persons deficient in vitamin D may be at much greater risk of developing diabetes. (Mehr in: Cancer News — ScienceDaily)

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Gene-edited stem cells show promise against HIV in non-human primates

19. Apr. 2018

Gene editing of bone marrow stem cells in pigtail macaques infected with simian/human immunodeficiency virus (SHIV) significantly reduces the size of dormant ‚viral reservoirs‘ that pose a risk of reactivation. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

11. Bamberger Neuropsychologie-Tag

04. Apr. 2018

Neuropsychologinnen und Neuropsychologen aus Deutschland und der Schweiz referieren über aktuelle Forschungen und deren klinische Implikationen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Anwendertage – Plasmaoberflächentechnologie

01. Apr. 2018

Plasmagestützte Oberflächentechnologie bietet Ihnen einen großen Baukasten an Optionen, neuartige Produkte zu entwickeln sowie das Anwendungsspektrum bereits existierender Produkte oder ihre Funktionalität zu erweitern. Im Rahmen der Anwendertage am INP Greifswald stellen wir Ihnen die Chancen dieser Technologien greifbar und verständlich vor und demonstrieren, wie Sie diese in Ihre Produktion integrieren und für die Entwicklung neuartiger Produkte nutzen können. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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17. FEI-Kooperationsforum "Proteinversorgung der Zukunft" (inkl. TROPHELIA Deutschland 2018)

01. Apr. 2018

Die Ressourcen werden knapper. Gleichzeitig stehen große gesellschaftliche Herausforderungen wie Klimawandel und Bevölkerungswachstum und die damit verbundene Nahrungssicherung auf dem Plan: Im Jahr 2050 werden laut Prognosen 9,8 Milliarden Menschen auf der Erde leben, die mit Lebensmitteln versorgt werden müssen. Vor diesem Hintergrund sind auch reiche Industrieländer wie Deutschland gefragt, Ansätze und Lösungen für eine alternative Proteinversorgung zu entwickeln. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Laboratoriumsmedizin im Klinikum rechts der Isar – von POCT bis Diagnosen in der Notfallmedizin

01. Apr. 2018

Um den Austausch zwischen Labormedizinern und Ingenieuren aus Industrie und Forschung zu fördern, veranstaltet das Institut für Klinische Chemie und Pathobiochemie des Klinikums rechts der Isar in München gemeinsam mit der Deutschen Gesellschaft für Biomedizinische Technik im VDE (DGBMT) den eintägigen Praxis-Workshop „Laboratoriumsmedizin für Ingenieure“. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Frühjahrsforum der Deutschen Hochschulmedizin

01. Apr. 2018

„Die politische Agenda in der neuen Legislaturperiode“ ist der Titel des Frühjahrsforum 2018 der Deutschen Hochschulmedizin. In diesem Jahr wirft die Veranstaltung einen Blick auf die Themen der Hochschulmedizin, die in der kommenden Wahlperiode eine besondere Rolle spielen werden. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Forum Bioethik: Gar nicht so selten – Herausforderungen im Umgang mit seltenen Erkrankungen

01. Apr. 2018

Öffentliche Abendveranstaltung des Deutschen Ethikrates

Mittwoch, 25. April 2018, 18:00 Uhr

Berlin-Brandenburgische Akademie der Wissenschaften, Leibniz-Saal Markgrafenstraße 38 10117 Berlin (U2 Hausvogteiplatz oder Stadtmitte, U6 Französische Straße oder Stadtmitte)

Anmeldung erforderlich bis 20. April 2018.

Für Hörgeschädigte steht während der Veranstaltung eine Simultanmitschrift zur Verfügung. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Fortbildungstag Cyclovoltammetrie – Grundlagen, Interpretation und Fehlerquellen

01. Apr. 2018

Die Cyclovoltammetrie zählt zu den bedeutendsten elektrochemischen Analysenmethoden. Anwendungsfelder sind die Elektrosynthese, Elektrokatalyse, Materialentwicklung, Sensorik und Korrosionsforschung. Auch im Bereich der Batterie- und Brennstoffzellenforschung und der Biowissenschaften erweist sich die Cyclovoltammetrie als nützliches Werkzeug. Der Kurs bietet die Gelegenheit, Grundkenntnisse und Problemlösungsstrategien zu erlernen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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