Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Chromatin structure mutes enhancer activity

In early embryos it is not possible to distinguish between arms and legs: their developmental precursors are virtually identical. Dynamic changes in the 3D structure of the chromatin in the leg precursor cells bring the Pen enhancer into spatial proximity to the Pitx1 gene, thus enabling the activation of this critical gene specifically in the future leg. As a result, forelimb and hindlimb buds subsequently differentiate from each other and produce arms and legs, respectively. This surprising molecular mechanism has been discovered by scientists around Stefan Mundlos and Guillaume Andrey from the Max Planck Institute for Molecular Genetics and the […]

Chromatin-Struktur legt Enhancer still

Im frühen Embryo lässt sich nicht erkennen, was ein Arm wird und was ein Bein: Die Knospen für die Extremitäten sehen zunächst identisch aus. Durch dynamische Veränderungen in der 3D-Struktur des Chromatins wird bei den unteren Extremitätenknospen der Enhancer Pen in räumliche Nähe zu dem Gen Pitx1 gebracht und kann es aktivieren. So erwachsen aus den oberen Knospen Arme und aus den unteren Beine. Den erstaunlichen molekularen Mechanismus haben Wissenschaftlerinnen und Wissenschaftler um Guillaume Andrey und Stefan Mundlos vom Max-Planck-Institut für molekulare Genetik und der Charité – Universitätsmedizin Berlin entdeckt und jetzt im renommierten Fachblatt „Nature Genetics“ veröffentlicht. (Mehr in: […]

Chromatinstruktur – Packen und entpacken

Im Zellkern ist das Erbgut dicht gewickelt. Trotzdem muss die Zelle immer wieder unterschiedliche Gene zugänglich machen. LMU-Forscher haben nun einen Mechanismus entschlüsselt, wie die molekularen Maschinen dabei DNA mit einem Zollstock aus Proteinen abmessen. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

3D structure of DNA forms defined room for dissociated lncRNAs to activate gene expression

Enhancers are regulatory regions of the DNA, giving rise to “long non-coding RNAs” (lncRNAs), which are known as crucial regulators of gene expression. Scientists from the Max Planck Institute for Molecular Genetics in Berlin now have shown that a lncRNA called A-ROD is only functional the moment it is released from chromatin into the nucleoplasm. In the current issue of Nature Communications the researchers demonstrate that the regulatory interaction requires dissociation of A-ROD from chromatin, with target specificity ensured within the pre-established chromosomal proximity. This can heavily influence our understanding of dynamic regulation of gene expression in biological processes. (Mehr […]

3D-Struktur der DNA bildet umschriebenen Raum zur Aktivierung der Genexpression durch freie lncRNAs

Forscher/innen des Max-Planck-Instituts für molekulare Genetik (MPIMG) in Berlin konnten zeigen, dass eine lncRNA namens A-ROD nur funktionstüchtig ist, wenn sie vom Chromatin in das Kernplasma abgegeben wird. In der aktuellen Ausgabe der Zeitschrift Nature Communications beschreiben die Wissenschaftler/innen, dass sich A-ROD vollständig vom Chromatin ablösen muss, um regulatorisch aktiv werden zu können. Durch die dreidimensionale Struktur der DNA wird gewährleistet, dass sich A-ROD bei der Ablösung bereits in direkter Nähe zu seinem Zielgen befindet. Dies kann unser Verständnis der dynamischen Regulation der Genexpression in biologischen Prozessen stark beeinflussen. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Probing RNA epigenetics and chromatin structures to predict drug resistance in leukemia

A research team has begun to unravel the role of RNA epigenetics and chromatin structure in the regulation of 5-azacytidine, a DNA hypomethylating agent in certain leukemias. The results could lead to novel strategies and biomarkers that could reduce the risk of drug resistance. (Mehr in: Cancer News — ScienceDaily)

‚Icebreaker‘ protein opens genome for T-cell development, researchers find

Researchers describe the role of a transcription factor called TCF-1 in targeting the condensed chromatin and regulating the availability of genome sequences in T-cell development. The new connection between TCF-1 and chromatin will aid in developing new therapies using epigenetic drugs to alter T-cell fate in cancer, autoimmune disorders, and infectious diseases. (Mehr in: Cancer News — ScienceDaily)

Unveiling how nucleosome repositioning occurs to shed light on genetic diseases

For the first time, researchers have unveiled the three-dimensional structure of an overlapping dinucleosome, a newly discovered chromatin structural unit. This may explain how nucleosome repositioning occurs and provide valuable information for understanding chromatin dynamics during transcription and developing drugs to treat genetic diseases. (Mehr in: Cancer News — ScienceDaily)

Powerful optical imaging technology catches DNA naturally fluorescing

Biomedical engineers have developed imaging technology that is the first to see DNA ‚blink,‘ or fluoresce. The tool enables researchers to study individual biomolecules (DNA, chromatin, proteins) as well as important global patterns of gene expression, which could yield insights into cancer. (Mehr in: Cancer News — ScienceDaily)

Mechanical force triggers gene expression by stretching chromatin

How genes in our DNA are expressed into traits within a cell is a complicated mystery with many players, the main suspects being chemical. However, a new study has demonstrated that external mechanical force can directly regulate gene expression. The study also identified the pathway that conveys the force from the outside of the cell into the nucleus. (Mehr in: Cancer News — ScienceDaily)

Cancer news

Cancer stem cells use normal genes in abnormal ways

12. Okt. 2018

An new study shows that CDK1 directly interacts with Sox2 to keep cancer cells ‚stemmy.‘ (Mehr in: Cancer News — ScienceDaily)

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New model mimics human tumors for accurate testing of cancer drugs

11. Okt. 2018

Researchers have genetically engineered a new laboratory model that enables accurate testing of anti-cancer drugs by mimicking the complexity of human cancers. Using this advanced model, researchers will be able to discover the safest and most effective ways to use promising drugs called MCL-1 inhibitors in the clinic. (Mehr in: Cancer News — ScienceDaily)

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Redrawing the structure of an immune system protein

10. Okt. 2018

Researchers have revealed the structure of an essential immune protein, creating future possibilities to develop more effective medicines for a range of illnesses from cancer to neurological diseases. Researchers made this discovery with computerized image analysis and modern electron microscope imaging. (Mehr in: Cancer News — ScienceDaily)

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Path to deadly sepsis varies by bacterial infection

10. Okt. 2018

Sepsis remains a common and deadly condition that occurs when the body reacts to an infection in the bloodstream. However, scientists know little about the early stages of the condition. Now, researchers have discovered that host responses during sepsis progression can vary in important ways based on pathogen type — which could lead to more effective treatments. (Mehr in: Cancer News — ScienceDaily)

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Air pollution may be linked to heightened mouth cancer risk

10. Okt. 2018

High levels of air pollutants, especially fine particulate matter (PM2.5) and to a lesser extent, ozone, may be linked to a heightened risk of developing mouth cancer, suggests the first study of its kind. (Mehr in: Cancer News — ScienceDaily)

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Supercharged natural killer cells may hold promise for cancer

09. Okt. 2018

New research suggests that a type of ‚supercharged‘ immune cell could be mass-produced to help fight cancer. (Mehr in: Cancer News — ScienceDaily)

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Statins show little promise for conditions other than heart disease

09. Okt. 2018

Medicines commonly prescribed to reduce people’s risk of heart attack may have limited use for treating other diseases, research suggests. (Mehr in: Cancer News — ScienceDaily)

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Immunotherapy effective against hereditary melanoma

09. Okt. 2018

Individuals with an inherited form of skin cancer often have a poor prognosis. The type of immunotherapy that was awarded this year’s Nobel Prize in Physiology or Medicine is, however, particularly effective in this patient group, new research shows. (Mehr in: Cancer News — ScienceDaily)

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Mechanism of resistance to novel targeted therapy for ovarian cancer identified

09. Okt. 2018

Scientists have unraveled a mechanism of resistance to EZH2 inhibitors in ovarian cancers with mutations in the ARID1A gene. (Mehr in: Cancer News — ScienceDaily)

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Neoadjuvant combination checkpoint blockade trial yields high response rates for patients with high-risk stage three melanoma

08. Okt. 2018

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage three melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early. (Mehr in: Cancer News — ScienceDaily)

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There’s a better way to decipher DNA’s epigenetic code to identify disease

08. Okt. 2018

A new method for sequencing the chemical groups attached to the surface of DNA is paving the way for better detection of cancer and other diseases in the blood. These chemical groups mark one of the four DNA ‚letters‘ in the genome, and it is differences in these marks along DNA that control which genes are expressed or silenced. (Mehr in: Cancer News — ScienceDaily)

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Novel technology enables detection of early-stage lung cancer when surgical cure still is possible

08. Okt. 2018

To improve outcomes for patients with non-small-cell lung carcinoma researchers are developing a blood test to detect lung cancer earlier in the disease. A report describes a new technology, electric field-induced release and measurement (EFIRM) that is both highly sensitive and specific in detecting two epidermal growth factor receptor (EGFR) mutations associated with lung cancer in the blood of NSCLC patients with early-stage disease. This platform is relatively inexpensive and capable of high-throughput testing. (Mehr in: Cancer News — ScienceDaily)

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New cancer vaccine platform a potential tool for efficacious targeted cancer therapy

05. Okt. 2018

Researchers have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment. (Mehr in: Cancer News — ScienceDaily)

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Aggressive prostate and lung cancers are driven by common mechanisms, researchers find

04. Okt. 2018

Researchers have discovered a common process in the development of late-stage, small cell cancers of the prostate and lung. These shared molecular mechanisms could lead to the development of drugs to treat not just prostate and lung cancers, but small cell cancers of almost any organ. (Mehr in: Cancer News — ScienceDaily)

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How malaria infection activates natural killer cells

04. Okt. 2018

Malaria-infected red blood cells trigger the immune system’s first line of defense by releasing small vesicles that activate a pathogen recognition receptor called MDA5, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Rewriting the textbook on how steroid hormones enter cells

04. Okt. 2018

A discovery may open up new ways to control steroid hormone-mediated processes, including growth and development in insects, and sexual maturation, immunity, and cancer progression in humans. (Mehr in: Cancer News — ScienceDaily)

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New DNA tool predicts height, shows promise for serious illness assessment

04. Okt. 2018

A new DNA tool can accurately predict people’s height, and more importantly, could potentially assess their risk for serious illnesses, such as heart disease and cancer. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

13. ITG Fachtagung Sprachkommunikation

09. Okt. 2018

Die Tagung der Informationstechnischen Gesellschaft (ITG), einer Fachgesellschaft des Verbands der Elektrotechnik, Elektronik, Informationstechnik (VDE), ist eins der größten Treffen von Wissenschaftlern und Praktikern auf dem Gebiet der Sprachverarbeitung im deutschsprachigen Raum. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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62. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V.

01. Okt. 2018

Bereits zum zweiundsechzigsten Mal findet 2018 der Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V. statt. Vom 31. Oktober bis 3. November diskutieren über 5.000 Expertinnen und Experten im Berliner CityCube den aktuellen Stand der Wissenschaft und Forschung sowie die Zukunft des Fachgebiets der Frauenheilkunde und Geburtshilfe. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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5th International Conference on Cellular Materials (CellMAT), 24 – 26 October

01. Okt. 2018

The 5th CellMAT conference will cover all aspects of manufacturing, functionalizing, modification, joining, property analysis and modelling of cellular materials. In addition to this, featured side events will focus on specific topics. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Einführung in die additive Fertigung

01. Okt. 2018

Das Thema additive Fertigung, d.h. der direkte schichtweise Aufbau von Produkten, ist aktuell sehr stark in das Interesse der polymer- und metallverarbeitenden Industrie sowie des produzierenden Gewerbes gerückt. Allein basierend auf 3D-Konstruktionsdaten können auf verschiedene Weisen Bauteile mit integrierten Funktionalitäten ohne Verwendung eines Werkzeuges realisiert werden, die konventionell so nicht herstellbar sind. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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CISCEM 2018 – 4th International Conference on In Situ and Correlative Electron Microscopy

01. Okt. 2018

CISCEM aims at bringing together an interdisciplinary group of scientists from the fields of biology, materials science, chemistry, and physics, to discuss future directions of in-situ electron microscopy research. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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BfR-Akademie Fortbildung: Transfer von Stoffen entlang der Nahrungskette – Teil 2

01. Okt. 2018

https://www.bfr-akademie.de/deutsch/veranstaltungen/transfer2.html (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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7T and beyond: 12th Erwin L. Hahn Lecture

01. Okt. 2018

Höher, schneller, weiter – die immer größer werdenden Feldstärken der MRTs erlauben einmalige und faszinierend detaillierte Aufnahmen aus dem Innern des menschlichen Körpers. Aber bringt die Ultra-Hochfeld-MRT auch Nachteile mit sich? Welchen Schwierigkeiten sehen sich die Forscher und Mediziner bei solch hohen Magnetfeldstärken ausgesetzt? Mit diesen und anderen Fragen beschäftigt sich die diesjährige Erwin L. Hahn Workshop & Lecture unter dem Thema „7T and Beyond“. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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