Doctors dramatically reduce racial disparities in early-stage lung cancer treatment

A pragmatic system-based intervention within cancer treatment centers can eliminate existing disparities in treatment and outcomes for black patients with early-stage lung cancer across the U.S. The treatment rates before this three-part intervention were 78 percent for white patients versus 69 percent for black patients. With the intervention in place, treatment rates climbed to 95 percent for white patients and 96.5 percent for black patients.

Quelle: Sciencedaily

Cost effectiveness of early cancer surveillance

New research shows how early cancer screening and surveillance in patients with Li-Fraumeni syndrome (LFS) results in additional years of life, and is cost effective for third-party payers.

Quelle: Sciencedaily

Mother’s age, race, weight affect hormone concentrations in pregnancy

Hormone concentrations during early fetal development — that may affect the child’s development and increase the mother’s risk for breast and ovarian cancer years later — are significantly affected by maternal age, body mass index and race rather than lifestyle, according to a new study.

Quelle: Sciencedaily

Shared genetic marker offers new promise in targeting specific ovarian and lung cancers

Two new articles offer promise that a drug currently used to treat estrogen positive breast cancer may be effective in treating two different types of cancer, one rare and one common form.

Quelle: Sciencedaily

Mapping esophageal cancer genes leads to new drug targets

Mutations that cause esophageal adenocarcinoma (OAC) have been mapped in unprecedented detail — unveiling that more than half could be targeted by drugs currently in trials for other cancer types.

Quelle: Sciencedaily

Digital attack on cancer

Several research groups at Berlin Institute of Health (BIH) are working on digitally combating cancer. The main goal is to combine and jointly evaluate existing information. With 500,000 new cancer cases every year in Germany alone, it is worthwhile comparing experiences with different diagnostic and treatment methods, thus allowing more patients to benefit from the most promising approaches. In addition, the BIH Digital Health Accelerator is helping innovators at Charité – Universitätsmedizin Berlin and the Max Delbrück Center to quickly bring digital ideas for cancer medicine to patients.

Quell: IDW Informationsdienst Wissenschaft

How the immune system protects us against bowel cancer

Researchers have discovered a protective mechanism which is used by the body to protect intestinal stem cells from turning cancerous. The body’s innate immune system was found to play a pivotal role in this regard. The researchers were able to demonstrate that, rather than having a purely defensive role, the immune system is crucial in maintaining a healthy body.

Quelle: Sciencedaily

Method to ‚turn off‘ mutated melanoma

Melanoma is the deadliest form of skin cancer and notorious for its resistance to conventional chemotherapy. Approximately 25 percent of melanoma is driven by oncogenic mutations in the NRAS gene, making it a very attractive therapeutic target. However, despite decades of research, no effective therapies targeting NRAS have been forthcoming.

Quelle: Sciencedaily

Opposite effect: Protein widely known to fight tumors also boosts cancer growth

Researchers studying p53, the heralded cancer-fighting ‚guardian of the genome,‘ found that the human protein also plays a role in promoting tumors, in addition to suppressing them. They found that the PUMA protein works inside the cell’s mitochondria to switch energy production processes and stimulate cancer growth.

Quelle: Sciencedaily

20th International AEK Cancer Congress

Die Abteilung experimentelle Krebsforschung (AEK) der Deutschen Krebsgesellschaft veranstaltet alle 2 Jahre den International AEK Cancer Congress. Hier wird der aktuelle Stand der experimentellen Krebsforschung vorgestellt und diskutiert. Der Kongress ist das wichtigste Forum der grundlagenorientierten Krebsforschung im deutschsprachigen Raum. Referenten sind renommierte Experten verschiedener medizinischer Disziplinen und Forschungsrichtungen aus dem In- und Ausland. www.aek-congress.org

Quelle: IDW Informationsdienst Wissenschaft

Breaking new ground in study of malignant pediatric brain tumor

Researchers identified a series of cancer-causing driver gene mutations and discovered that medulloblastoma is perhaps an even more dynamic and variable tumor than expected.

Quelle: Sciencedaily

Many women get unnecessary mammograms before breast reduction surgery

Getting a mammogram before breast reduction surgery is not required or recommended. But thousands of younger women with no known breast cancer risk still get them, a new study shows.

Quelle: Sciencedaily

New target for gastric cancer therapies

Researchers have uncovered new information about the underlying mechanisms for gastric cancer, providing hope of potential new therapies in the future.

Quelle: Sciencedaily

Engineering a cancer-fighting virus

An engineered virus kills cancer cells more effectively than another virus currently used in treatments, according to researchers.

Quelle: Sciencedaily

Persistent sore throat could be larynx cancer warning

Doctors should consider larynx cancer when patients report a persistent sore throat, particularly when combined with other seemingly low-level symptoms.

Quelle: Sciencedaily

Tongue microbiome could help identify patients with early-stage pancreatic cancer

Differences in the abundance of certain bacteria living on the tongue can distinguish patients with early pancreatic cancers from healthy individuals, according to results from a new study.

Quelle: Sciencedaily

Weltkrebstag: „Ich bin und ich werde“ – Deutsche Leberstiftung fordert Prävention und Früherkennung

Anlässlich des Weltkrebstages am 4. Februar 2019 ruft die Welt-Krebsorganisation (Union Internationale Contre le Cancer – UICC) unter dem Motto „Ich bin und ich werde“ dazu auf, über die Möglichkeiten und die Wichtigkeit der Krebsprävention zu informieren. Darüber hinaus sollen an dem weltweiten Aktionstag die aktuellen Entwicklungen in den Bereichen Krebsfrüherkennung, Diagnose, Therapie, Nachsorge und Forschung in den Fokus gesetzt werden. Die Deutsche Leberstiftung nimmt den diesjährigen Weltkrebstag zum Anlass, um auf die steigende Zahl der Leberzellkrebs-Erkrankungen, die Wichtigkeit einer frühzeitigen Diagnose und die vermeidbaren Risikofaktoren hinzuweisen.

Quell: IDW Informationsdienst Wissenschaft

Drug compound could be next-generation treatment for aggressive form of leukemia

Researchers are developing a series of drug compounds that have shown promise in treating acute myeloid leukemia, an aggressive blood cancer that is one of the most lethal cancers. About 19,520 news cases are diagnosed a year, and about 10,670 people a year die from it, according to the American Cancer Society. About 30 percent of AML patients have a mutation caused by a kinase called FLT3, which makes the leukemia more aggressive.

Quelle: Sciencedaily

Finding second hits to knock out leukemia

Targeted drugs are a cornerstone of personalized medicine, yet come with important drawbacks. They restrain disease progression — but rarely eradicate the cancer. Patients therefore need to take the drugs essentially forever, exposing them to severe side effects and incurring high costs for the healthcare system. Combination therapies could potentially overcome these limitations. A new study shows how epigenetic analysis and automated microscopy help prioritize new drug combinations for leukemia therapy.

Quelle: Sciencedaily

Cancer: A mutation that breaks gene interplay in 3D

Scientists have discovered how a mutated gene can affect the three-dimensional interactions of genes in the cell, leading to various forms of cancer.

Quelle: Sciencedaily

Effective method for reducing hospital stay after ‚whipple‘ operation

Implementing a new recovery pathway speeds time to next treatment for pancreatic cancer patients by 15 days, without increasing complication rates.

Quelle: Sciencedaily

Study may explain why once-promising cancer drugs failed

Nearly two decades ago, a class of once-promising cancer drugs called MMP inhibitors mysteriously failed in clinical trials. Now scientists think they may have an explanation. A new study shows that when MMP enzymes are disabled, invasive cells can change their tactics. The findings in C. elegans worms could lead to better ways to prevent metastasis, the spread of the disease responsible for 90 percent of cancer deaths.

Quelle: Sciencedaily

Cancer has a biological clock and this drug may keep it from ticking

Scientists find and test a promising drug that stops cancer by interfering with the cancer cells‘ metabolism and other circadian-related functions.

Quelle: Sciencedaily

In surprising reversal, scientists find a cellular process that stops cancer before it starts

Scientists studying the relationship of telomeres to cancer made a surprising discovery: a cellular recycling process called autophagy — generally thought of as a survival mechanism — actually promotes the death of cells, thereby preventing cancer initiation.

Quelle: Sciencedaily

Targeted treatment shrinks deadly pediatric brain tumors

For children — whose tiny bodies are still growing — chemotherapy and radiation treatments can cause lifelong damage. Now, scientists have reported that a targeted therapy that blocks a protein called LSD1 was able to shrink tumors in mice with a form of pediatric brain cancer known as medulloblastoma. LSD1 inhibitors are currently under evaluation in clinical trials for other cancers.

Quelle: Sciencedaily