High-contrast imaging for cancer therapy with protons

Medical physicists have combined magnetic resonance imaging with a proton beam, thus demonstrating that in principle, this commonly used imaging method can indeed work with particle beam cancer treatments. This opens up new opportunities for targeted, healthy tissue-sparing cancer therapy. (Mehr in: Cancer News — ScienceDaily)

Cutting the legs off cancer

Melanoma skin cancer tumors grow larger and are more likely to metastasize due to interactions between a pair of molecules, according to experiments in mice and human cells. The results may restore the potential for a type of cancer therapy previously abandoned in clinical trials. The results also implicate one molecule already connected to obesity and dementia as a potential cause of metastasis, or spread of cancer cells to other areas of the body. (Mehr in: Cancer News — ScienceDaily)

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy

Researchers have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment. (Mehr in: Cancer News — ScienceDaily)

Olfactory cells may act as ‚Trojan horse,‘ carry anticancer therapy to deadly brain tumors

Researchers have found that a special type of cell essential to the ability of olfactory neurons to regenerate may be genetically engineered to deliver anticancer therapy to the dangerous brain tumors called glioblastomas. (Mehr in: Cancer News — ScienceDaily)

Key role found for enzymes in DNA replication and sensitivity to chemotherapeutic drugs

A new study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA. The research is based on previous studies that pointed to TLK1/2 as potential candidate targets in cancer therapy, and it provides new molecular details on their key functions in cancer cell proliferation. (Mehr in: Cancer News — ScienceDaily)

Sensor could help doctors select effective cancer therapy

Chemical engineers have developed a sensor that lets them see hydrogen peroxide inside cancer cells and determine whether they are responding to drugs that affect redox signaling. (Mehr in: Cancer News — ScienceDaily)

A major step towards individualized cancer therapy

Scientists have succeeded in establishing a versatile, powerful and convenient model to analyze human cancer. (Mehr in: Cancer News — ScienceDaily)

How might baking soda boost cancer therapy?

A new study has uncovered an entirely novel mechanism by which cells enter a state of dormancy as tissues starved of oxygen become increasingly acidic. (Mehr in: Cancer News — ScienceDaily)

Combination pack battles cancer

For efficient cancer therapy with few side effects, the active drug should selectively attain high concentration in the tumor. Scientists have introduced a new approach, in which two synergistic drug components are combined into a dimer. This dimer can be incorporated into polymeric nanotransporters at exceptionally high concentration. The components are activated when the dimer is split within the tumor. In addition, they enable use of two different imaging techniques. (Mehr in: Cancer News — ScienceDaily)

Treatment of cancer could become possible with adenovirus

Researchers have shown that adenovirus binds to a specific type of carbohydrate that is overexpressed on certain types of cancer cells. The discovery opens up new opportunities for the development of virus-based cancer therapy. (Mehr in: Cancer News — ScienceDaily)

Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex SF3B. Researchers led by Vlad Pena at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen have now succeeded for the first time in deciphering in atomic detail how an anti-tumor agent binds to SF3B and how it modulates its function. The new findings provide an important basis for further improving potential cancer drugs that target SF3B. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Breast cancer therapy: All clear for the heart

Many breast cancer therapies cause damage to the heart. However, in the largest study of its kind so far, scientists have now shown that the risk of death from heart disease in breast cancer patients following radiotherapy or chemotherapy is no higher than it is among the average population. Good risk management in the hospitals as well as control screenings at short intervals seem to make up for elevated risks. (Mehr in: Cancer News — ScienceDaily)

New compound helps activate cancer-fighting T cells

Chemists have created a new lipid antigen that helps stimulate disease-fighting T cells in the immune system, opening up new paths for the development of better cancer therapy drugs and vaccines. (Mehr in: Cancer News — ScienceDaily)

Stealth virus for cancer therapy

Scientists have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells. (Mehr in: Cancer News — ScienceDaily)

Stealth Virus for Cancer Therapy

Scientists from the University of Zurich have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

Boosting cancer therapy with artificial molecules

Researchers have created artificial molecules that can help the immune system to recognize and attack cancer tumors. (Mehr in: Cancer News — ScienceDaily)

Berry gives boost to cervical cancer therapy

According to the Centers for Disease Control and Prevention, approximately 12,000 women in the United States are diagnosed with cervical cancer each year. One of the most common treatments for cervical cancer is radiation. While radiation therapy destroys cancer cells, it also destroys nearby healthy cells. Researchers studied in vitro human cancer cells to show that combining blueberry extract with radiation can increase the treatment’s effectiveness. (Mehr in: Cancer News — ScienceDaily)

Breast cancer patients forego post-surgery treatment due to mistrust, study suggests

Nearly one-third of women with breast cancer went against their doctor’s advice and chose not to begin or complete the recommended adjuvant anti-cancer therapy to kill residual tumor cells following surgery, according to a study. (Mehr in: Cancer News — ScienceDaily)

‚Double decker‘ antibody technology fights cancer

Scientists have created a new class of antibody-drug conjugates for cancer therapy, outlines a new report. (Mehr in: Cancer News — ScienceDaily)

Novel mechanism of resistance to anti-cancer drugs

Investigators have discovered a novel non-genetic cause of resistance to the targeted anti-cancer therapy cetuximab. Their findings suggest a strategy for overcoming this resistance. (Mehr in: Cancer News — ScienceDaily)

Pathway’s power to boost, halt tumors may be promising cancer therapy target

A protein, called inositol-requiring enzyme 1 — IRE1 — may serve as a key driver in a series of molecular interactions that can both promote and, paradoxically, inhibit tumors in certain types of cancers, such as non-melanoma skin cancers, according to a team of molecular biologists. They add that this pathway’s dual power may make it a tempting target for future research on the design of new types of anti-cancer therapeutics. (Mehr in: Cancer News — ScienceDaily)

Complete remission of brain metastasis of difficult-to-treat tumor

Medical researchers report a remarkable treatment response in a patient participating in a clinical trial of a novel immune-system-based cancer therapy. (Mehr in: Cancer News — ScienceDaily)

Anti-inflammatory therapy cuts risk of lung cancer

In most clinical trials for cancer therapy, investigators test treatments in patients with advanced disease. But a recent cardiovascular secondary prevention study has given researchers a unique opportunity: to explore the effectiveness of giving a drug to patients before cancer emerges. (Mehr in: Cancer News — ScienceDaily)

Cancer-fighting T cells are smarter, stronger than experts thought

It takes a minuscule amount of force to make T cells behave in the lab as they behave in the body. That finding is a leap in cancer therapy research. (Mehr in: Cancer News — ScienceDaily)

Discovery of new prostate cancer biomarkers could improve precision therapy

A new cause of treatment resistance in prostate cancer has been uncovered by investigators. Their discovery also suggests ways to improve prostate cancer therapy. (Mehr in: Cancer News — ScienceDaily)