Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

[ read more ]

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

[ read more ]

Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

[ read more ]

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

[ read more ]

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

[ read more ]

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

[ read more ]

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

[ read more ]

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

[ read more ]

Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to inhibitory signals, evasion of programmed cell death and limitless replicative potential with a potential for the invasion of other organs. Cancer disease is widespread among metazoans. Some properties of cancer cells such as uncontrolled cell proliferation, lack of apoptosis, hypoxia, fermentative metabolism and free cell motility, i.e. metastasis, resemble a prokaryotic lifestyle, which leads to the assumption of a reversal like evolution from eucariotic back to proteobacterial state. This phenotype matches the phenotype of the last universal common ancestor (LUCA) that resulted from the endosymbiosis between archaebacteria and α-proteobacteria, which later became the mitochondria.

 Davila AF and Zamorano P (2013) Mitochondria and the evolutionary roots of cancer. Phys. Biol. 10 (2013) 026008, doi:10.1088/1478-3975/10/2/026008

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection.

Warburg O, Posener K, Negelein E. (1924) Über den Stoffwechsel der Carcinomzelle. Biochem Z. 152, 309–344.

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming

Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abrupt shifts in diseases. Discrete changes in nuclear gene expression in response to small increases in DNA mutant level are analogous to the phase shifts that is well known in physics: As heat is added, the ice abruptly turns to water or with more heat abruptly to steam. Therefore, a quantitative change that is an increasing proportion of mitochondrial DNA mutation results in a qualitative change  which coordinate changes in nuclear gene expression together with discrete changes in clinical symptoms.

 Wallace DC (2005) A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine. Annu Rev Genet. 2005 ; 39: 359. doi:10.1146/annurev.genet.39.110304.095751

Picard M et. Al (2014) Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming. PNAS E4033–E4042, doi: 10.1073/pnas.1414028111

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to bad luck, that is, random mutations arising during DNA replication in normal, noncancerous stem cells.

Tomasetti C, Vogelstein B (2015): Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 2 January 2015: Vol. 347 no. 6217 pp. 78-81 DOI: 10.1126/science.1260825

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline solid. However, living organisms are essentially isothermal. Because of very little differences in temperature between different parts of a cell it is assumed that energy flow in living organisms is mediated by differences in the turnover time of various metabolic processes in the cell, which occur in cyclical fashion. It has been shown that the cycle time of these metabolic processes is related to the metabolic rate, that is the rate at which the organism transforms the free energy of whatever source into metabolic work, maintenance of constant temperature and structuraland functional organization of the cells. Quantum Metabolism exploits the methodology of the quantum theory of solids to provide a molecular level which derives new rules relating metabolic rate and body size.

Davies P, Lloyd A, Demetrius LA, Tuszynski, JA (2012) Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression. Citation: AIP Advances 2, 011101 (2012); doi: 10.1063/1.3697850

Einstein A (1920), Schallausbreitung in teilweise dissozieirten Gasen

Einstein A (1924) Quantentheorie des einatomigen, idealen Gases

Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy of the molecule. Derived in the limit of long distances and periodic potentials analytic expressions linking the entanglement witnesses to the energy reduction due to the quantum entanglement in the electron clouds.

Rieper E, Anders J, Vedral V (2011) Quantum entanglement between the electron clouds of nucleic acids in DNA. arxiv.org/abs/1006.4053

 

Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is the quantum potential which sustains intimately within the underlying implicates order and the quantum processes are driven by information from quantum potential. A global quantum field of a cell, which can be described as a super orbital, provides many levels of interactions among all particles of a cell. From quantum metabolism pint of view all electrons that are contained in one system are inseparable from eachother. In a cell the cytoplasm is a gel made of up to 30% proteins, and the structure of this gel is very much like a liquid crystal which provides collective properties of the electrons.

All these electrons within this super orbital of molecules and co-enzymes of the cell, including all the many small molecules embedded in these large biomolecules, and cofactors transporting electrons are making up one huge structure that is a global cell orbital.

Bohm D (1980) Wholeness and implicate order. Routledge Classics Eds., London and New York 191-247.

Ventegodt S, Hermansen TD, Flensborg-Madsen T, Nielsen ML and Merrick J (2006) A theory of “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior. The Scientific World Journal 6, 1441-1453.

Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital importance for life: physical and chemical processes can be traced directly back to the effects of quantum tunnelling. These processes include the   prebiotic chemistry as well as the function of biomolecular nanomachines and has many highly important implications that can be derived from to the field of molecular, prebiotic chemistry and biological evolution, respectively.

Trixler, F (2013) Quantum Tunnelling to the Origin and Evolution of Life. Curr Org Chem. 2013 Aug; 17(16): 1758–1770. doi: 10.2174%2F13852728113179990083

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is dominantly responsible for the joint entropy at the final stage. If it is far from the computational basis, this dominant responsibility is moved into the quantum measurement of system. Therefore, the relative entropy can be regarded as a measure for distance between two different quantum states like trace distance or fidelity. Some relative entropies become infinity, which indicates the non-trivial intersection of the support of one quantum state with kernel of the other quantum state.

You Hwan Ju, Eylee Jung1, Mi-Ra Hwang, D. K. Park, Hungsoo Kim, Min-Soo Kim, Jin-Woo Son, Sahng-Kyoon Yoo, S. Tamaryan (2007) Quantum Teleportation and Von Neumann Entropy. arXiv:0707.1227v1

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination – still below heating threshold – may selectively target centrioles, impair mitosis and be a beneficial therapy against malignancy. If centrioles utilize quantum photons for entanglement, properties of centrosomes/centrioles approached more specifically could be useful for therapy. Healthy centrioles for a given organism or tissue differentiation should then have specific quantum optical properties detectable through some type of readout technology. An afflicted patient’s normal cells could be examined to determine the required centriole properties which may then be used to generate identical quantum coherent photons administered to the malignancy. In this mode the idea would not be to destroy the tumor – relatively low energy lasers would be used – but to “reprogram” or redifferentiate the centrioles and transform the tumor back to healthy well differentiated tissue.

Hameroff, SR (2004) A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation. BioSystems 77, 119–136

Cancer news

Cancer: New compound targets energy generation, thereby killing metastatic cells

17. Okt. 2017

Researchers have identified an enzyme that supports the survival and dissemination of metastatic cells, and developed a synthetic compound that targets the enzyme and kills the metastatic cells in mice with cancer. (Mehr in: Cancer News — ScienceDaily)

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Timing of melanoma diagnosis, treatment critical to survival

17. Okt. 2017

A new study underscores the importance of early detection and treatment of melanoma, the deadliest form of skin cancer. The research indicates that the sooner patients were treated, the better their survival, particularly for stage I melanoma. (Mehr in: Cancer News — ScienceDaily)

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Many pelvic tumors in women may have common origin: Fallopian tubes

17. Okt. 2017

Most, and possibly all, ovarian cancers start, not in ovaries, but instead in the fallopian tubes attached to them, report investigators. (Mehr in: Cancer News — ScienceDaily)

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Novel mechanism of resistance to anti-cancer drugs

17. Okt. 2017

Investigators have discovered a novel non-genetic cause of resistance to the targeted anti-cancer therapy cetuximab. Their findings suggest a strategy for overcoming this resistance. (Mehr in: Cancer News — ScienceDaily)

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Biology of childhood brain tumor subtypes offers clues to precision treatments

17. Okt. 2017

Researchers investigating pediatric low-grade gliomas (PLGG), the most common type of brain tumor in children, have discovered key biological differences in how mutated genes combine with other genes to drive this childhood cancer. By shedding light on subtle distinctions in tumor biology, these findings offer clues to designing more effective anticancer treatments to precisely target tumors in individual patients. (Mehr in: Cancer News — ScienceDaily)

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Bolstering fat cells offers potential new leukemia treatment

16. Okt. 2017

Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, says a new study. Researchers found that boosting adipocytes, or fat cells, located in the bone morrow suppressed cancerous leukemia cells but — in a surprise to the research team — also induced the regeneration of healthy blood cells. (Mehr in: Cancer News — ScienceDaily)

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Scientists identify biomarker for progression, drug response in brain cancer

16. Okt. 2017

Scientists have reported results from a glioblastoma study in which they validated a biomarker indicative of a patient’s prognosis and likely response to specific therapies. (Mehr in: Cancer News — ScienceDaily)

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Scientists demonstrate path to linking the genome to healthy tissues, disease

16. Okt. 2017

A study has reached a major milestone in establishing a baseline understanding of gene expression across healthy human tissues, and linking genes to disease. (Mehr in: Cancer News — ScienceDaily)

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Scientists reveal the relationship between sugar, cancer

13. Okt. 2017

A nine-year joint research project has led to a crucial breakthrough in cancer research. Scientists have clarified how the Warburg effect, a phenomenon in which cancer cells rapidly break down sugars, stimulates tumor growth. This discovery provides evidence for a positive correlation between sugar and cancer, which may have far-reaching impacts on tailor-made diets for cancer patients. (Mehr in: Cancer News — ScienceDaily)

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Liquid biopsy for retinoblastoma

12. Okt. 2017

A new study provides proof of concept for a safe and effective way to derive genetic information from a retinoblastoma tumor. (Mehr in: Cancer News — ScienceDaily)

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3D packaging of DNA regulates cell identity

12. Okt. 2017

The ability of a stem cell to differentiate into cardiac muscle (and by extension other cell types) depends on what portions of the genome are available for activation, which is controlled by the location of DNA in a cell’s nucleus, new research suggests. (Mehr in: Cancer News — ScienceDaily)

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Mechanism for precise targeting of the immune response uncovered

12. Okt. 2017

The immune system checks the health of cells of the body by examining a kind of molecular passport. Sometimes cells present the wrong passport, which can lead to autoimmune diseases, chronic inflammations or cancer. Scientists can now explain the process how this happens. (Mehr in: Cancer News — ScienceDaily)

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Scientists pinpoint surprising origin of melanoma

12. Okt. 2017

A team of researchers has tracked down the cellular origin of cutaneous melanoma, the deadliest form of skin cancer. The team was surprised to observe that these very aggressive tumors arise from mature, pigment-producing cells called melanocytes. As melanoma develops, these cells are eventually reprogrammed, lose their differentiated features and become invasive, migratory cancer cells. This knowledge is vital to understand how these melanoma lesions are formed, facilitate their early detection and develop preventive treatment avenues. (Mehr in: Cancer News — ScienceDaily)

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Chemistry provides a new supply of a promising cancer and HIV treatment

12. Okt. 2017

Supplies of a promising drug for cancer, HIV and possibly other diseases is dwindling, and scientists have struggled to extract more from the marine creatures who produce it. Now, chemists have a synthetic solution. (Mehr in: Cancer News — ScienceDaily)

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Cause of cancer form in the liver identified

12. Okt. 2017

Researchers have identified the two genes whose mutation cause a serious cancer form found in the liver. The result sets concrete goals for future treatment of the otherwise incurable disease. (Mehr in: Cancer News — ScienceDaily)

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New drug hope for rare bone cancer patients

12. Okt. 2017

Patients with a rare bone cancer of the skull and spine — chordoma — could be helped by existing drugs, suggest scientists. In the largest genomics study of chordoma to date, scientists show that a group of chordoma patients have mutations in genes that are the target of existing drugs, known as PI3K inhibitors. (Mehr in: Cancer News — ScienceDaily)

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Studies advance methods to avert toxicity that can accompany immunotherapy

12. Okt. 2017

Two new papers provide the most comprehensive data yet reported on side effects of the emerging cancer immunotherapy strategy known as CAR T-cell therapy. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

100 Jahre Zukunft. Die Mistel in der Krebstherapie

01. Okt. 2017

Die Misteltherapie – immer noch umstritten oder längst etabliert? Antworten auf diese Frage gibt es beim Symposium „100 Jahre Zukunft. Die Mistel in der Krebstherapie“ am 21. Oktober 2017 in Berlin. Das Symposium richtet sich an Ärzte, Pharmazeuten, Therapeuten, Pflegende und Patienten. Theorie und Praxis kommen gleichermaßen zu Wort: Best-Practice, Erfahrungen und spannende Forschungsergebnisse werden vorgestellt. Diskussionen und Roundtables ergänzen das Programm. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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100 Jahre Max-Planck-Institut für Physik – Jubiläumssymposium und Festakt

01. Okt. 2017

Das Max-Planck-Institut für Physik begeht seinen 100. Jahrestag: Am 1. Oktober 1917 nahm das damalige Kaiser-Wilhelm-Institut für Physik unter Direktor Albert Einstein seine Arbeit auf. Dieses Jubiläum feiert das MPI für Physik mit einem wissenschaftlichen Symposium, das vom 10. bis 12. Oktober 2017 stattfindet. Ein anschließender Festakt mit Abendprogramm beschließt die Feierlichkeiten zum 100-jährigen Bestehen des Instituts. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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1st Gießen Symposium of Insect Biotechnology

01. Okt. 2017

We are delighted to invite delegates to the 1st Gießen Symposium for Insect Biotechnology. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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19th Herbstakademie

01. Okt. 2017

Embodied Aesthetics: Resonance in Perception, Expression and Therapy (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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17. Wissenschaftliche Jahrestagung der DGSF

01. Okt. 2017

Von der Neutralität zur Parteilichkeit – SystemikerInnen mischen sich ein (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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16. Deutscher Kongress für Versorgungsforschung

01. Okt. 2017

Unter dem Thema: „Zukunft Regionale Versorgung – Forschung, Innovation, Kooperation“ wird vom 4. bis 6. Oktober 2017 der 16. Deutsche Kongress für Versorgungsforschung (DKVF2016) in der Urania in Berlin stattfinden. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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22. International Biohydrometallurgy Symposium

01. Sep. 2017

Call for Papers is open – submit your contribution until 10 January 2017

The biannual International Biohydrometallurgy Symposium is the global forum for experts from academia and industry active in the fields of biomining, bioleaching and bioremediation. These technologies have a high potential to establish environmentally favourable processes for the recovery of primary and secondary precious and base metal resources as well as the remediation of exploited mining sites. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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