Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

[ read more ]

Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

[ read more ]

Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

[ read more ]

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

[ read more ]

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

[ read more ]

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

[ read more ]

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

[ read more ]

Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

[ read more ]

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

[ read more ]

Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

[ read more ]

Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to inhibitory signals, evasion of programmed cell death and limitless replicative potential with a potential for the invasion of other organs. Cancer disease is widespread among metazoans. Some properties of cancer cells such as uncontrolled cell proliferation, lack of apoptosis, hypoxia, fermentative metabolism and free cell motility, i.e. metastasis, resemble a prokaryotic lifestyle, which leads to the assumption of a reversal like evolution from eucariotic back to proteobacterial state. This phenotype matches the phenotype of the last universal common ancestor (LUCA) that resulted from the endosymbiosis between archaebacteria and α-proteobacteria, which later became the mitochondria.

 Davila AF and Zamorano P (2013) Mitochondria and the evolutionary roots of cancer. Phys. Biol. 10 (2013) 026008, doi:10.1088/1478-3975/10/2/026008

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection.

Warburg O, Posener K, Negelein E. (1924) Über den Stoffwechsel der Carcinomzelle. Biochem Z. 152, 309–344.

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming

Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abrupt shifts in diseases. Discrete changes in nuclear gene expression in response to small increases in DNA mutant level are analogous to the phase shifts that is well known in physics: As heat is added, the ice abruptly turns to water or with more heat abruptly to steam. Therefore, a quantitative change that is an increasing proportion of mitochondrial DNA mutation results in a qualitative change  which coordinate changes in nuclear gene expression together with discrete changes in clinical symptoms.

 Wallace DC (2005) A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine. Annu Rev Genet. 2005 ; 39: 359. doi:10.1146/annurev.genet.39.110304.095751

Picard M et. Al (2014) Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming. PNAS E4033–E4042, doi: 10.1073/pnas.1414028111

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to bad luck, that is, random mutations arising during DNA replication in normal, noncancerous stem cells.

Tomasetti C, Vogelstein B (2015): Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 2 January 2015: Vol. 347 no. 6217 pp. 78-81 DOI: 10.1126/science.1260825

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline solid. However, living organisms are essentially isothermal. Because of very little differences in temperature between different parts of a cell it is assumed that energy flow in living organisms is mediated by differences in the turnover time of various metabolic processes in the cell, which occur in cyclical fashion. It has been shown that the cycle time of these metabolic processes is related to the metabolic rate, that is the rate at which the organism transforms the free energy of whatever source into metabolic work, maintenance of constant temperature and structuraland functional organization of the cells. Quantum Metabolism exploits the methodology of the quantum theory of solids to provide a molecular level which derives new rules relating metabolic rate and body size.

Davies P, Lloyd A, Demetrius LA, Tuszynski, JA (2012) Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression. Citation: AIP Advances 2, 011101 (2012); doi: 10.1063/1.3697850

Einstein A (1920), Schallausbreitung in teilweise dissozieirten Gasen

Einstein A (1924) Quantentheorie des einatomigen, idealen Gases

Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy of the molecule. Derived in the limit of long distances and periodic potentials analytic expressions linking the entanglement witnesses to the energy reduction due to the quantum entanglement in the electron clouds.

Rieper E, Anders J, Vedral V (2011) Quantum entanglement between the electron clouds of nucleic acids in DNA. arxiv.org/abs/1006.4053

 

Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is the quantum potential which sustains intimately within the underlying implicates order and the quantum processes are driven by information from quantum potential. A global quantum field of a cell, which can be described as a super orbital, provides many levels of interactions among all particles of a cell. From quantum metabolism pint of view all electrons that are contained in one system are inseparable from eachother. In a cell the cytoplasm is a gel made of up to 30% proteins, and the structure of this gel is very much like a liquid crystal which provides collective properties of the electrons.

All these electrons within this super orbital of molecules and co-enzymes of the cell, including all the many small molecules embedded in these large biomolecules, and cofactors transporting electrons are making up one huge structure that is a global cell orbital.

Bohm D (1980) Wholeness and implicate order. Routledge Classics Eds., London and New York 191-247.

Ventegodt S, Hermansen TD, Flensborg-Madsen T, Nielsen ML and Merrick J (2006) A theory of “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior. The Scientific World Journal 6, 1441-1453.

Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital importance for life: physical and chemical processes can be traced directly back to the effects of quantum tunnelling. These processes include the   prebiotic chemistry as well as the function of biomolecular nanomachines and has many highly important implications that can be derived from to the field of molecular, prebiotic chemistry and biological evolution, respectively.

Trixler, F (2013) Quantum Tunnelling to the Origin and Evolution of Life. Curr Org Chem. 2013 Aug; 17(16): 1758–1770. doi: 10.2174%2F13852728113179990083

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is dominantly responsible for the joint entropy at the final stage. If it is far from the computational basis, this dominant responsibility is moved into the quantum measurement of system. Therefore, the relative entropy can be regarded as a measure for distance between two different quantum states like trace distance or fidelity. Some relative entropies become infinity, which indicates the non-trivial intersection of the support of one quantum state with kernel of the other quantum state.

You Hwan Ju, Eylee Jung1, Mi-Ra Hwang, D. K. Park, Hungsoo Kim, Min-Soo Kim, Jin-Woo Son, Sahng-Kyoon Yoo, S. Tamaryan (2007) Quantum Teleportation and Von Neumann Entropy. arXiv:0707.1227v1

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination – still below heating threshold – may selectively target centrioles, impair mitosis and be a beneficial therapy against malignancy. If centrioles utilize quantum photons for entanglement, properties of centrosomes/centrioles approached more specifically could be useful for therapy. Healthy centrioles for a given organism or tissue differentiation should then have specific quantum optical properties detectable through some type of readout technology. An afflicted patient’s normal cells could be examined to determine the required centriole properties which may then be used to generate identical quantum coherent photons administered to the malignancy. In this mode the idea would not be to destroy the tumor – relatively low energy lasers would be used – but to “reprogram” or redifferentiate the centrioles and transform the tumor back to healthy well differentiated tissue.

Hameroff, SR (2004) A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation. BioSystems 77, 119–136

Cancer news

Tweaking cells‘ gatekeepers could lead to new way to fight cancer

19. Sep. 2018

Researchers have devised a way to manipulate numbers of individual nuclear pores — a breakthrough that may one day stop cancerous cells from proliferating out of control. (Mehr in: Cancer News — ScienceDaily)

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New hurdle for developing immunotherapies

18. Sep. 2018

A new discovery tosses a new wrench into the process of building better molecules to develop immunotherapies. (Mehr in: Cancer News — ScienceDaily)

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Eating foods with low nutritional quality ratings linked to cancer risk in large European cohort

18. Sep. 2018

The consumption of foods with higher scores on the British Food Standards Agency nutrient profiling system (FSAm-NPS), reflecting a lower nutritional quality, is associated with an increased risk of developing cancer. (Mehr in: Cancer News — ScienceDaily)

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How cells repurpose their garbage disposal systems to promote inflammation

18. Sep. 2018

Researchers have unraveled new insights into the way cells leverage G-protein-coupled receptors (GPCRs) and their cellular waste disposal systems to control inflammation. The findings suggest some existing cancer drugs that inhibit these cellular activities might be repurposed to treat vascular inflammation, which occurs when artery-blocking plaques form in atherosclerosis. (Mehr in: Cancer News — ScienceDaily)

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CRISPR screen reveals new targets in more than half of all squamous cell carcinomas

18. Sep. 2018

Researchers sheds light on p63 activity in squamous cell carcinoma of the lung, providing an actionable path forward to drug development against this known cause of cancer. (Mehr in: Cancer News — ScienceDaily)

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Chemists create circular fluorescent dyes for biological imaging

18. Sep. 2018

Chemists have created a new class of fluorescent dyes that function in water and emit colors based solely on the diameter of circular nanotubes made of carbon and hydrogen. (Mehr in: Cancer News — ScienceDaily)

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Colon cancer is caused by bacteria and cell stress

18. Sep. 2018

Scientists have made an unexpected discovery while investigating the triggering factors of colon cancer: Cell stress in combination with an altered microbiota in the colon drives tumor growth. Previously, it was assumed that this combination only contributes to inflammatory intestinal diseases. (Mehr in: Cancer News — ScienceDaily)

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Better chemo drug adsorption onto targeted delivery capsules

18. Sep. 2018

One of the challenges in cancer research is improving the delivery of chemo drugs to enhance their efficacy while decreasing the risk of side effects. Scientists now perform a theoretical prediction of adsorption of a well-known chemo drug onto active carbon with aluminium inclusions, to show its potential as an oral chemotherapy delivery capsule. (Mehr in: Cancer News — ScienceDaily)

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Zika vaccine shows promise for treating deadly brain cancer

18. Sep. 2018

Researchers have successfully deployed a Zika virus vaccine to target and kill human glioblastoma brain cancer stem cells, which had been transplanted into mice. In a new study, the team shows that a live, attenuated version of the Zika virus could form the basis of a new treatment option for this fatal brain cancer. (Mehr in: Cancer News — ScienceDaily)

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Silicone breast implants linked to increased risk of some rare harms

18. Sep. 2018

Women receiving silicone breast implants may be at increased risk of several rare adverse outcomes compared to the general population. (Mehr in: Cancer News — ScienceDaily)

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Artificial intelligence can determine lung cancer type

17. Sep. 2018

A new computer program can analyze images of patients‘ lung tumors, specify cancer types, and even identify altered genes driving abnormal cell growth, a new study shows. (Mehr in: Cancer News — ScienceDaily)

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Developmental stage for No. 1 eye tumor in children

17. Sep. 2018

Investigators have been able to pinpoint the exact stage of development of the human retina, when cells can grow out of control and form cancer-like masses. The finding could open the door for future interventions in retinoblastoma (RB), a tumor of the retina that affects children under five years of age. (Mehr in: Cancer News — ScienceDaily)

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New blood test detects early stage pancreatic cancer

17. Sep. 2018

Pancreatic cancer is currently very difficult to detect while it is still resectable. A new blood test can detect pancreatic cancer in the very earliest stages of the disease. (Mehr in: Cancer News — ScienceDaily)

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Daily low-dose aspirin found to have no effect on healthy life span in older people

16. Sep. 2018

In a clinical trial to determine the effects of daily low-dose aspirin in healthy older adults without previous cardiovascular events, aspirin did not prolong healthy, independent living free of dementia or physical disability. (Mehr in: Cancer News — ScienceDaily)

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Research in yeast leads to serendipitous finding about a central nervous system disorder

14. Sep. 2018

Researchers found that an important quality control mechanism in baker’s yeast is closely connected to hypomyelinating leukodystrophy, a debilitating disease found in children. The findings could indicate a therapeutic approach for this rare disease, as well as for multiple sclerosis and other neurodegenerative diseases. (Mehr in: Cancer News — ScienceDaily)

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New method promises fewer side effects from cancer drugs

14. Sep. 2018

A recent achievement in the field of protein research allows for better tailored pharmaceuticals with fewer side effects. (Mehr in: Cancer News — ScienceDaily)

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Cancer drug and antidepressants provide clues for treating brain-eating amoeba infections

13. Sep. 2018

Researchers have now identified three new molecular drug targets in Naegleria fowleri and a number of drugs that are able to inhibit the amoeba’s growth in a laboratory dish. Several of these drugs are already approved by the US Food and Drug Administration for other uses, such as antifungal agents, the breast cancer drug tamoxifen and antidepressant Prozac. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

11. Bundesalgenstammtisch 2018; Mikroalgen für Umwelt und Wertschöpfung

01. Sep. 2018

Der jährlich stattfindende „Bundesalgenstammtisch“ ist die deutschsprachige Kommunikationsplattform für alle, die mit der Algenbiotechnologie in Wissenschaft und Industrie befasst sind. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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18. Scientific Meeting (ScieM)

01. Sep. 2018

Am 27. und 28. September 2018 findet das 18. Scientific Meeting (ScieM) des Mukoviszidose e.V. in Bad Salzschlirf statt. Thema des diesjährigen Meetings sind „Anti-inflammatorische Therapien im Kontext des Mikrobioms in Lunge und Darm“. Mukoviszidose-Forscherinnen und -Forscher aus der ganzen Welt sind dazu eingeladen, beim Meeting über dieses zurzeit sehr relevante Forschungsthema zu diskutieren. Abstracts für Vorträge können bis zum 15. Juni 2018 eingereicht werden. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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17. Tag der Arbeitsmedizin in Berlin

01. Sep. 2018

Dialogforen Arbeitsmedizin und Arbeitssicherheit – Eine Veranstaltungsreihe für Wissenschaft und Praxis der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. (DGAUM) und RG GmbH (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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17. Jahrestagung der CURAC auf dem Leipziger Medizincampus

01. Sep. 2018

Vom 13.-15.09.2018 findet auf dem Medizincampus Leipzig die 17. Jahrestagung der Deutschen Gesellschaft für Computer- und Roboterassistierte Chirurgie (CURAC) statt. Sie ist das zentrale deutschsprachige Forum für technische Entwicklungen und klinische Anwendungen im Bereich informationsgestützte Chirurgie. Erwartet werden ca. 150 AnwenderInnen und EntwicklerInnen zum fachlichen Austausch. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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12. Kongress der Deutschen Gesellschaft für Palliativmedizin

01. Sep. 2018

Die Deutsche Gesellschaft für Palliativmedizin (DGP) lädt die in Palliativforschung und -versorgung Tätigen zum 12. Kongress unter dem Leitmotiv „Auf breiten Wegen: Integration, Innovation, Intuition“ nach Bremen ein. Sowohl in Plenarvorträgen mit renommierten Rednern verschiedener Disziplinen als auch in Workshops, Meet the Experts, Falldiskussionen und 35 Parallelsitzungen besteht Gelegenheit, sich mit Fragen zur Begleitung und Versorgung von Menschen in ihrer letzten Lebensphase zu befassen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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4th Forum on Hydrothermal Processes "Technologies generating material and energetic added value"

01. Sep. 2018

The event will be bilingual – German and English with simultaneous translation. Presentations and posters will be available in both languages. If you are interested in participating in the event with a presentation/talk or poster, please submit your Application form by May 1st, 2018 via e-mail to htp-inno@dbfz.de.

Accepted abstracts will appear in the conference reader. For accepted posters, a short introduction (three minutes, one slide) will be provided in addition to the poster exhibiton. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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4. Tag der Arbeitsmedizin in Hannover

01. Sep. 2018

Dialogforen Arbeitsmedizin und Arbeitssicherheit – Eine Veranstaltungsreihe für Wissenschaft und Praxis der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. (DGAUM) und RG GmbH (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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