Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

[ read more ]

Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

[ read more ]

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

[ read more ]

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

[ read more ]

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

[ read more ]

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

[ read more ]

Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

[ read more ]

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

[ read more ]

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

[ read more ]

Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to inhibitory signals, evasion of programmed cell death and limitless replicative potential with a potential for the invasion of other organs. Cancer disease is widespread among metazoans. Some properties of cancer cells such as uncontrolled cell proliferation, lack of apoptosis, hypoxia, fermentative metabolism and free cell motility, i.e. metastasis, resemble a prokaryotic lifestyle, which leads to the assumption of a reversal like evolution from eucariotic back to proteobacterial state. This phenotype matches the phenotype of the last universal common ancestor (LUCA) that resulted from the endosymbiosis between archaebacteria and α-proteobacteria, which later became the mitochondria.

 Davila AF and Zamorano P (2013) Mitochondria and the evolutionary roots of cancer. Phys. Biol. 10 (2013) 026008, doi:10.1088/1478-3975/10/2/026008

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection.

Warburg O, Posener K, Negelein E. (1924) Über den Stoffwechsel der Carcinomzelle. Biochem Z. 152, 309–344.

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming

Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abrupt shifts in diseases. Discrete changes in nuclear gene expression in response to small increases in DNA mutant level are analogous to the phase shifts that is well known in physics: As heat is added, the ice abruptly turns to water or with more heat abruptly to steam. Therefore, a quantitative change that is an increasing proportion of mitochondrial DNA mutation results in a qualitative change  which coordinate changes in nuclear gene expression together with discrete changes in clinical symptoms.

 Wallace DC (2005) A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine. Annu Rev Genet. 2005 ; 39: 359. doi:10.1146/annurev.genet.39.110304.095751

Picard M et. Al (2014) Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming. PNAS E4033–E4042, doi: 10.1073/pnas.1414028111

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to bad luck, that is, random mutations arising during DNA replication in normal, noncancerous stem cells.

Tomasetti C, Vogelstein B (2015): Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 2 January 2015: Vol. 347 no. 6217 pp. 78-81 DOI: 10.1126/science.1260825

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline solid. However, living organisms are essentially isothermal. Because of very little differences in temperature between different parts of a cell it is assumed that energy flow in living organisms is mediated by differences in the turnover time of various metabolic processes in the cell, which occur in cyclical fashion. It has been shown that the cycle time of these metabolic processes is related to the metabolic rate, that is the rate at which the organism transforms the free energy of whatever source into metabolic work, maintenance of constant temperature and structuraland functional organization of the cells. Quantum Metabolism exploits the methodology of the quantum theory of solids to provide a molecular level which derives new rules relating metabolic rate and body size.

Davies P, Lloyd A, Demetrius LA, Tuszynski, JA (2012) Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression. Citation: AIP Advances 2, 011101 (2012); doi: 10.1063/1.3697850

Einstein A (1920), Schallausbreitung in teilweise dissozieirten Gasen

Einstein A (1924) Quantentheorie des einatomigen, idealen Gases

Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy of the molecule. Derived in the limit of long distances and periodic potentials analytic expressions linking the entanglement witnesses to the energy reduction due to the quantum entanglement in the electron clouds.

Rieper E, Anders J, Vedral V (2011) Quantum entanglement between the electron clouds of nucleic acids in DNA. arxiv.org/abs/1006.4053

 

Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is the quantum potential which sustains intimately within the underlying implicates order and the quantum processes are driven by information from quantum potential. A global quantum field of a cell, which can be described as a super orbital, provides many levels of interactions among all particles of a cell. From quantum metabolism pint of view all electrons that are contained in one system are inseparable from eachother. In a cell the cytoplasm is a gel made of up to 30% proteins, and the structure of this gel is very much like a liquid crystal which provides collective properties of the electrons.

All these electrons within this super orbital of molecules and co-enzymes of the cell, including all the many small molecules embedded in these large biomolecules, and cofactors transporting electrons are making up one huge structure that is a global cell orbital.

Bohm D (1980) Wholeness and implicate order. Routledge Classics Eds., London and New York 191-247.

Ventegodt S, Hermansen TD, Flensborg-Madsen T, Nielsen ML and Merrick J (2006) A theory of “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior. The Scientific World Journal 6, 1441-1453.

Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital importance for life: physical and chemical processes can be traced directly back to the effects of quantum tunnelling. These processes include the   prebiotic chemistry as well as the function of biomolecular nanomachines and has many highly important implications that can be derived from to the field of molecular, prebiotic chemistry and biological evolution, respectively.

Trixler, F (2013) Quantum Tunnelling to the Origin and Evolution of Life. Curr Org Chem. 2013 Aug; 17(16): 1758–1770. doi: 10.2174%2F13852728113179990083

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is dominantly responsible for the joint entropy at the final stage. If it is far from the computational basis, this dominant responsibility is moved into the quantum measurement of system. Therefore, the relative entropy can be regarded as a measure for distance between two different quantum states like trace distance or fidelity. Some relative entropies become infinity, which indicates the non-trivial intersection of the support of one quantum state with kernel of the other quantum state.

You Hwan Ju, Eylee Jung1, Mi-Ra Hwang, D. K. Park, Hungsoo Kim, Min-Soo Kim, Jin-Woo Son, Sahng-Kyoon Yoo, S. Tamaryan (2007) Quantum Teleportation and Von Neumann Entropy. arXiv:0707.1227v1

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination – still below heating threshold – may selectively target centrioles, impair mitosis and be a beneficial therapy against malignancy. If centrioles utilize quantum photons for entanglement, properties of centrosomes/centrioles approached more specifically could be useful for therapy. Healthy centrioles for a given organism or tissue differentiation should then have specific quantum optical properties detectable through some type of readout technology. An afflicted patient’s normal cells could be examined to determine the required centriole properties which may then be used to generate identical quantum coherent photons administered to the malignancy. In this mode the idea would not be to destroy the tumor – relatively low energy lasers would be used – but to “reprogram” or redifferentiate the centrioles and transform the tumor back to healthy well differentiated tissue.

Hameroff, SR (2004) A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation. BioSystems 77, 119–136

Cancer news

New inflammation inhibitor discovered

15. Nov. 2018

A multidisciplinary team of researchers have developed an anti-inflammatory drug molecule with a new mechanism of action. By inhibiting a certain protein, the researchers were able to reduce the signals that trigger an inflammation. (Mehr in: Cancer News — ScienceDaily)

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Drug combination makes cancer disappear in mice with neuroblastoma

15. Nov. 2018

Researchers investigating new treatments for neuroblastoma — one of the most common childhood cancers — have found that a combination of two drugs made tumors disappear in mice, making it more effective than any other drugs tested in these animals. (Mehr in: Cancer News — ScienceDaily)

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A new approach to detecting cancer earlier from blood tests

14. Nov. 2018

Cancer scientists have combined ‚liquid biopsy,‘ epigenetic alterations and machine learning to develop a blood test to detect and classify cancer at its earliest stages. (Mehr in: Cancer News — ScienceDaily)

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Rainforest vine compound starves pancreatic cancer cells

14. Nov. 2018

Pancreatic cancer cells are known for their ability to thrive under extreme conditions of low nutrients and oxygen, a trait known in the cancer field as ‚austerity.‘ The cells‘ remarkable resistance to starvation is one reason why pancreatic cancer is so deadly. Now researchers have identified a compound from a Congolese plant that has strong “antiausterity“ potential, making pancreatic cancer cells susceptible to nutrient starvation. (Mehr in: Cancer News — ScienceDaily)

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Synthetic DNA-delivered antibodies protect against Ebola in preclinical studies

13. Nov. 2018

Scientists have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Study results showed that DMAbs were expressed over a wide window of time and offered complete and long-term protection against lethal virus challenges. DMAbs may also provide a novel powerful platform for rapid screening of monoclonal antibodies enhancing preclinical development. (Mehr in: Cancer News — ScienceDaily)

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New methods to identify Alzheimer’s drug candidates with anti-aging properties

13. Nov. 2018

Old age is the greatest risk factor for many diseases, including Alzheimer’s disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. New research has now identified a unique subclass of these compounds, dubbed geroneuroprotectors (GNPs), which are AD drug candidates and slow the aging process in mice. (Mehr in: Cancer News — ScienceDaily)

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‚Waltzing‘ nanoparticles could advance search for better drug delivery methods

13. Nov. 2018

Scientists paired drug-delivering nanoparticles like dance partners to reveal that molecules attach to targets on cells differently based upon their position in time. The discovery could improve methods for screening drugs for therapeutic effectiveness. (Mehr in: Cancer News — ScienceDaily)

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Stealth-cap technology for light-emitting nanoparticles

13. Nov. 2018

Scientists have succeeded in significantly increasing the stability and biocompatibility of special light-transducing nanoparticles. They have developed so-called “upconverting“ nanoparticles that not only convert infrared light into UV-visible light, but also are water-soluble, remain stable in complex body fluids, and can be used to store medications. They have created a tool that could potentially make the fight against cancer more effective. (Mehr in: Cancer News — ScienceDaily)

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Cancer stem cells get energy from protein, and it’s proving to be their Achilles‘ heel

12. Nov. 2018

A new study shows that cancer stem cells switch from metabolizing sugar to metabolizing protein. Clinical trial based on this observation may revolutionize care for older adults with acute myeloid leukemia. (Mehr in: Cancer News — ScienceDaily)

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Weight during adolescence may affect pancreatic cancer risk in adulthood

12. Nov. 2018

New research has linked adolescent obesity with up to a four-fold increased risk of pancreatic cancer later in life. The study’s results also suggest that overweight and even higher weight within the ‚normal‘ weight range in men may increase pancreatic cancer risk in a graded manner. (Mehr in: Cancer News — ScienceDaily)

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Defective DNA damage repair leads to chaos in the genome

12. Nov. 2018

Scientists have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known for a few years: If an important DNA repair system of the cells has failed, this promotes fragmentation and defective assembly of the genetic material. Cancer cells with such a repair defect can now possibly be treated by a specific group of drugs. (Mehr in: Cancer News — ScienceDaily)

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Decrease in specific gene ‚silencing‘ molecules linked with pediatric brain tumors

12. Nov. 2018

Experimenting with lab-grown brain cancer cells, researchers have added to evidence that a shortage of specific tiny molecules that silence certain genes is linked to the development and growth of pediatric brain tumors known as low-grade gliomas. (Mehr in: Cancer News — ScienceDaily)

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Hidden estrogen receptors in breast epithelium

09. Nov. 2018

Scientists have uncovered that next to estrogen receptor positive and negative there are cells with very low amounts of the receptor protein. The discovery has significant implications for the role of the receptor in the growth and development of the breast and breast cancer development. (Mehr in: Cancer News — ScienceDaily)

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Scientists solve century-old neuroscience mystery; answers may lead to epilepsy treatment

09. Nov. 2018

Scientists have solved a 125-year-old mystery of the brain, and, in the process, uncovered a potential treatment for acquired epilepsy. Perineuronal nets modulate electrical impulses in the brain, and, should the nets dissolve, brain seizures can occur. (Mehr in: Cancer News — ScienceDaily)

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Genetic ‚whodunnit‘ for cancer gene solved

08. Nov. 2018

Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, researchers have solved the long-standing mystery around why AMPK can both hinder and help cancer. (Mehr in: Cancer News — ScienceDaily)

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What do metastatic cancer cells have in common with sharks?

08. Nov. 2018

In a new study, researchers report that when cancer cells become invasive (metastatic), they start behaving in ‚predatory‘ ways. Metastatic cancer cells differ from their non-metastatic counterparts not only in their genetics, but also in their moving strategy: they spread more rapidly and are more directional than non-invasive cancer cells. (Mehr in: Cancer News — ScienceDaily)

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Combination chemotherapy and immunotherapy effective in Phase II leukemia study

08. Nov. 2018

A combination of the standard-of-care chemotherapy drug known as azacitidine, with nivolumab, an immune checkpoint inhibitor, demonstrated an encouraging response rate and overall survival in patients with relapsed or refractory acute myeloid leukemia, according to new findings. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

4. BfR-Symposium Lebensmittelassoziierte Viren

01. Nov. 2018

Das 4. BfR-Symposium „Lebensmittelassoziierte Viren“ soll einen Austausch über Aspekte wie die aktuelle epidemiologische Situation einzelner Virusinfektionen, neuartige Nachweismethoden für Viren in Lebensmitteln oder Möglichkeiten für eine verbesserte Hygiene ermöglichen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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3. Tag der Arbeitsmedizin in Köln

01. Nov. 2018

Dialogforen Arbeitsmedizin und Arbeitssicherheit – Eine Veranstaltungsreihe für Wissenschaft und Praxis der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. (DGAUM) und RG GmbH (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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38. Marktplatz Gesundheit: „Klinische Bewertung nach der neuen MDR – die Zeit läuft“

01. Nov. 2018

Medizintechnik ist Technik für Menschen. Wer sie entwickelt, herstellt und vertreibt, unterliegt daher besonderen Vorschriften. Maßgeblich dafür ist die EU-Verordnung zu Medizinprodukten (Medical Device Regulation = MDR), welche durch die europäische Zulassung ab 2020 einheitlich geregelt wird. Dies bringt viele Änderungen mit sich. Jeder Hersteller von Medizinprodukten muss sich mit den neuen Anforderungen auseinandersetzen. Es gibt also viel zu bereden! (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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21. Deutsche Mukoviszidose Tagung (DMT)

01. Nov. 2018

Jedes Jahr im November veranstaltet der Mukoviszidose e.V. die Deutsche Mukoviszidose Tagung. An drei Tagen (22.-24.11.2018) wird ein breites Fort- und Weiterbildungsangebot für das interdisziplinäre Mukoviszidose-Behandler-Team präsentiert. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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21. Deutsche Mukoviszidose Tagung

01. Nov. 2018

Die Deutsche Mukoviszidose Tagung – mit jährlich rund 800 Teilnehmerinnen und Teilnehmern die größte Fortbildungsveranstaltung zur Mukoviszidose in Deutschland – richtet sich an das gesamte Behandler-Team und verbindet interdisziplinäre Fragestellungen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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1. Community Health Konferenz in Bochum

01. Nov. 2018

Das Department of Community Health (DoCH) der Hochschule für Gesundheit (hsg Bochum) veranstaltet die erste Community Health Konferenz an der hsg Bochum. Die Konferenz ist als Auftakt für eine jährliche Veranstaltung geplant, welche Wissenschaft, Praxis und Lehre anspricht und zusammenführt. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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100 Jahre Influenza – Wie gut sind wir für die nächste Pandemie vorbereitet?

01. Nov. 2018

Weshalb traf die Spanische Grippe, ausgelöst von einem H1N1 Influenzavirus, die Welt derart unvorbereitet? Wie gut wären wir gegen eine kommende Pandemie aufgestellt? Diesen Fragen der modernen Medizin geht Prof. Dr. Gülsah Gabriel in ihrem Vortrag zu 100 Jahren Influenza nach. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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