Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

[ read more ]

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

[ read more ]

Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

[ read more ]

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

[ read more ]

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

[ read more ]

Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

[ read more ]

Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

[ read more ]

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

[ read more ]

Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

[ read more ]

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

[ read more ]

Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to inhibitory signals, evasion of programmed cell death and limitless replicative potential with a potential for the invasion of other organs. Cancer disease is widespread among metazoans. Some properties of cancer cells such as uncontrolled cell proliferation, lack of apoptosis, hypoxia, fermentative metabolism and free cell motility, i.e. metastasis, resemble a prokaryotic lifestyle, which leads to the assumption of a reversal like evolution from eucariotic back to proteobacterial state. This phenotype matches the phenotype of the last universal common ancestor (LUCA) that resulted from the endosymbiosis between archaebacteria and α-proteobacteria, which later became the mitochondria.

 Davila AF and Zamorano P (2013) Mitochondria and the evolutionary roots of cancer. Phys. Biol. 10 (2013) 026008, doi:10.1088/1478-3975/10/2/026008

About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection.

Warburg O, Posener K, Negelein E. (1924) Über den Stoffwechsel der Carcinomzelle. Biochem Z. 152, 309–344.

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming

Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abrupt shifts in diseases. Discrete changes in nuclear gene expression in response to small increases in DNA mutant level are analogous to the phase shifts that is well known in physics: As heat is added, the ice abruptly turns to water or with more heat abruptly to steam. Therefore, a quantitative change that is an increasing proportion of mitochondrial DNA mutation results in a qualitative change  which coordinate changes in nuclear gene expression together with discrete changes in clinical symptoms.

 Wallace DC (2005) A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine. Annu Rev Genet. 2005 ; 39: 359. doi:10.1146/annurev.genet.39.110304.095751

Picard M et. Al (2014) Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming. PNAS E4033–E4042, doi: 10.1073/pnas.1414028111

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to bad luck, that is, random mutations arising during DNA replication in normal, noncancerous stem cells.

Tomasetti C, Vogelstein B (2015): Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 2 January 2015: Vol. 347 no. 6217 pp. 78-81 DOI: 10.1126/science.1260825

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline solid. However, living organisms are essentially isothermal. Because of very little differences in temperature between different parts of a cell it is assumed that energy flow in living organisms is mediated by differences in the turnover time of various metabolic processes in the cell, which occur in cyclical fashion. It has been shown that the cycle time of these metabolic processes is related to the metabolic rate, that is the rate at which the organism transforms the free energy of whatever source into metabolic work, maintenance of constant temperature and structuraland functional organization of the cells. Quantum Metabolism exploits the methodology of the quantum theory of solids to provide a molecular level which derives new rules relating metabolic rate and body size.

Davies P, Lloyd A, Demetrius LA, Tuszynski, JA (2012) Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression. Citation: AIP Advances 2, 011101 (2012); doi: 10.1063/1.3697850

Einstein A (1920), Schallausbreitung in teilweise dissozieirten Gasen

Einstein A (1924) Quantentheorie des einatomigen, idealen Gases

Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy of the molecule. Derived in the limit of long distances and periodic potentials analytic expressions linking the entanglement witnesses to the energy reduction due to the quantum entanglement in the electron clouds.

Rieper E, Anders J, Vedral V (2011) Quantum entanglement between the electron clouds of nucleic acids in DNA. arxiv.org/abs/1006.4053

 

Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is the quantum potential which sustains intimately within the underlying implicates order and the quantum processes are driven by information from quantum potential. A global quantum field of a cell, which can be described as a super orbital, provides many levels of interactions among all particles of a cell. From quantum metabolism pint of view all electrons that are contained in one system are inseparable from eachother. In a cell the cytoplasm is a gel made of up to 30% proteins, and the structure of this gel is very much like a liquid crystal which provides collective properties of the electrons.

All these electrons within this super orbital of molecules and co-enzymes of the cell, including all the many small molecules embedded in these large biomolecules, and cofactors transporting electrons are making up one huge structure that is a global cell orbital.

Bohm D (1980) Wholeness and implicate order. Routledge Classics Eds., London and New York 191-247.

Ventegodt S, Hermansen TD, Flensborg-Madsen T, Nielsen ML and Merrick J (2006) A theory of “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior. The Scientific World Journal 6, 1441-1453.

Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital importance for life: physical and chemical processes can be traced directly back to the effects of quantum tunnelling. These processes include the   prebiotic chemistry as well as the function of biomolecular nanomachines and has many highly important implications that can be derived from to the field of molecular, prebiotic chemistry and biological evolution, respectively.

Trixler, F (2013) Quantum Tunnelling to the Origin and Evolution of Life. Curr Org Chem. 2013 Aug; 17(16): 1758–1770. doi: 10.2174%2F13852728113179990083

Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is dominantly responsible for the joint entropy at the final stage. If it is far from the computational basis, this dominant responsibility is moved into the quantum measurement of system. Therefore, the relative entropy can be regarded as a measure for distance between two different quantum states like trace distance or fidelity. Some relative entropies become infinity, which indicates the non-trivial intersection of the support of one quantum state with kernel of the other quantum state.

You Hwan Ju, Eylee Jung1, Mi-Ra Hwang, D. K. Park, Hungsoo Kim, Min-Soo Kim, Jin-Woo Son, Sahng-Kyoon Yoo, S. Tamaryan (2007) Quantum Teleportation and Von Neumann Entropy. arXiv:0707.1227v1

A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination – still below heating threshold – may selectively target centrioles, impair mitosis and be a beneficial therapy against malignancy. If centrioles utilize quantum photons for entanglement, properties of centrosomes/centrioles approached more specifically could be useful for therapy. Healthy centrioles for a given organism or tissue differentiation should then have specific quantum optical properties detectable through some type of readout technology. An afflicted patient’s normal cells could be examined to determine the required centriole properties which may then be used to generate identical quantum coherent photons administered to the malignancy. In this mode the idea would not be to destroy the tumor – relatively low energy lasers would be used – but to “reprogram” or redifferentiate the centrioles and transform the tumor back to healthy well differentiated tissue.

Hameroff, SR (2004) A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation. BioSystems 77, 119–136

Cancer news

Embryonic mammary gland stem cells identified

22. Mai. 2018

Scientists have identified the mechanisms that regulate mammary gland development. Using a combination of lineage tracing, molecular profiling, single cell sequencing and functional experiments, they have demonstrated that mammary gland initially develops from multipotent progenitors during the early steps of embryonic mammary gland morphogenesis whereas postnatal mammary gland development is mediated by lineage-restricted stem cells. (Mehr in: Cancer News — ScienceDaily)

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New data changes the way scientists explain how cancer tumors develop

21. Mai. 2018

A collaborative research team has uncovered new information that more accurately explains how cancerous tumors grow within the body. This study is currently available in Nature Genetics. (Mehr in: Cancer News — ScienceDaily)

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Deep space radiation treatment reboots brain’s immune system

21. Mai. 2018

NASA and private company SpaceX plan to send humans to Mars within the next 15 years — but need to figure out how to protect astronauts from the dangerous cosmic radiation of deep space. Now neuroscientists have identified a potential treatment for the brain damage caused by cosmic rays — a drug that prevents memory impairment in mice exposed to simulated space radiation. (Mehr in: Cancer News — ScienceDaily)

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Are humans causing cancer in wild animals?

21. Mai. 2018

As humans, we know that some of our activities can cause cancer to develop in our bodies. Smoking, poor diets, pollution, chemicals used as additives in food and personal hygiene products, and even too much sun can contribute to an increased risk of cancer. But, are human activities also causing cancer in wild animals? Researchers think so and are urgently calling for research into this topic. (Mehr in: Cancer News — ScienceDaily)

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Scientist reveals likely cause of childhood leukemia

21. Mai. 2018

A major new analysis reveals for the first time the likely cause of most cases of childhood leukemia, following more than a century of controversy about its origins. (Mehr in: Cancer News — ScienceDaily)

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Fewer men are being screened, diagnosed, and treated for prostate cancer

21. Mai. 2018

A new study reveals declines in prostate cancer screening and diagnoses in the United States in recent years, as well as decreases in the use of definitive treatments in men who have been diagnosed. (Mehr in: Cancer News — ScienceDaily)

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MR spectroscopy imaging reveals effects of targeted treatment of mutant IDH1 gliomas

18. Mai. 2018

Using a novel imaging method, a research team is investigating the mechanisms behind a potential targeted treatment for a subtype of the deadly brains tumors called gliomas. (Mehr in: Cancer News — ScienceDaily)

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A way to prevent pancreatic cancer from spreading post-surgery?

17. Mai. 2018

New research suggests a strategy for lowering the odds of metastasis following successful pancreatic cancer surgery: The post-operative period, suggests a researcher, ‚offers a window during which efforts might be made to keep cortisol levels down and T cells strong so the patient’s own immune system can kill the cancer cells that have made their way to other parts of the body but until this point have been dormant.‘ (Mehr in: Cancer News — ScienceDaily)

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Immune cell provides cradle for mammary stem cells

17. Mai. 2018

Researchers have made new discoveries about how an immune cell known as the macrophage, which normally fights infection by swallowing foreign invaders, nurtures mammary gland stem cells through a chemical signaling molecule. The study may provide important clues about the roles of macrophages in breast cancer progression. (Mehr in: Cancer News — ScienceDaily)

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Single surface protein boosts multiple oncogenic pathways in acute myeloid leukemia

17. Mai. 2018

Researchers have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought. The study raises hopes that current efforts to target this signaling protein could be a successful strategy to treat AML and other blood cancers. (Mehr in: Cancer News — ScienceDaily)

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La Trobe’s infection-busting discovery

17. Mai. 2018

Scientists have shown a protein found in a tobacco plant has the potential to fight life-threatening infectious diseases. (Mehr in: Cancer News — ScienceDaily)

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Individualized ovarian, brain cancer therapies

16. Mai. 2018

Researchers have discovered that a molecular communication pathway — thought to be defective in cancer — is a key player in determining the effectiveness of measles virus oncolytic cancer treatment in ovarian and aggressive brain cancers. This discovery enabled researchers to develop an algorithm to predict treatment effectiveness in individual patients. (Mehr in: Cancer News — ScienceDaily)

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Diagnosing breast cancer with an imaging pill

16. Mai. 2018

For women, mammograms are a sometimes uncomfortable, but necessary, annual ritual. But this procedure doesn’t always provide accurate results, and it exposes women to X-rays. In a new study, scientists report that they have developed a non-invasive ‚disease screening pill‘ that can make cancerous tumors light up when exposed to near-infrared light in mice without using radiation. (Mehr in: Cancer News — ScienceDaily)

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Cell type switch helps colon cancer evade treatment, study suggests

16. Mai. 2018

Researchers have discovered that colon cancers are often resistant to existing drug treatments because they are composed of two different cell types that can replace each other when one cell type is killed. The study suggests that combination therapies targeting both cell types at once may be more effective at treating colorectal cancer, the third highest cause of cancer-related death in the United States. (Mehr in: Cancer News — ScienceDaily)

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Taming random gene changes as our bodies start to form

15. Mai. 2018

Scientists exploring how to tame random gene fluctuations as the embryos that become our bodies start to form have identified a control switch in the vertebrate segmentation clock of developing zebrafish. The researchers report their findings could uncover methods for modulating genetic signals to prevent birth defects or cancers rooted at the earliest stages of development. (Mehr in: Cancer News — ScienceDaily)

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Different diseases elicit distinct sets of exhausted T cells

15. Mai. 2018

The battle between the human immune system and long-term, persisting infections and other chronic diseases such as cancer results in a prolonged stalemate. Over time battle-weary T cells become exhausted, giving germs or tumors an edge. Using data from multiple molecular databases, researchers have found nine distinct types of exhausted T cells, which could have implications for fighting chronic infections, autoimmunity, and cancer. (Mehr in: Cancer News — ScienceDaily)

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First clues to the causes of multiple sclerosis

15. Mai. 2018

There is still no cure for multiple sclerosis, with current treatments largely based on managing symptoms, especially accelerating recovery phases following a relapse and reducing the number and severity of relapses. Researchers have now identified a DNA-binding factor called TOX that might play a role in triggering multiple sclerosis. They found that TOX license immune cells to cause autoimmune tissue destruction in the brain. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

102. Jahrestagung der Deutschen Gesellschaft für Pathologie e.V.

23. Mai. 2018

Vom 24. bis 26. Mai 2018 tagt die Deutsche Gesellschaft für Pathologie e.V. (DGP) in Berlin zum 102. Mal. Auch in diesem Jahr sind die Beiträge auf der Tagung durch die bahnbrechenden Entwicklungen im Bereich der Molekularpathologie und den Einzug digitaler Techniken in den Arbeitsalltag der Pathologinnen und Pathologen geprägt. Dieser Trend hat auch im besonderen Maße Einfluss auf die Schwerpunkte des Kongresses: Tumorevolution und Tumorheterogenität sowie seltene Erkrankungen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Das Babel-Projekt I – Epistemische Funktionen von Metaphern im wissenschaftlichen Erkenntnisprozess

02. Mai. 2018

Unsere Wahrnehmung der Welt und der wissenschaftliche Zugang zu ihrer kausalen Struktur sind wesentlich mit dem Gebrauch von Sprache – insbesondere Metaphern – verbunden. Metaphern erfüllen epistemische Funktionen, indem sie durch die Anlehnung an einen bekannten Quellbereich eine speziell geartete Vorstellung eines neuen, abstrakteren Konzeptes (Zielbereich) vermitteln. Sie sind somit auch für die Neukonstruktion und Artikulation von Theorien und Begriffen bedeutsam. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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89. Jahresversammlung der DGHNO KHC „Forschung heute – Zukunft morgen“

02. Mai. 2018

89. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V. (DGHNO KHC) „Forschung heute – Zukunft morgen“ Termin: Mittwoch, 9. Mai bis Samstag 12. Mai 2018 Ort: Musik- und Kongresshalle (MuK), Willy-Brandt-Allee 10, D-23554 Lübeck (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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7. Jahrestreffen der Seniorexperten Chemie

02. Mai. 2018

Seniorenchemiker in Weimar – Chemie zwischen Klassik und Moderne (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

02. Mai. 2018

Date: 15-18 May 2018 Location: Kloster Irsee (Bavaria, Germany)

There is growing interest from academia and industry in high-temperature shape memory alloys, as these represent a fascinating field both from a basic science and an application point of view. Recent literature demonstrates that substantial progress has been made since the first conference in 2015 exclusively devoted to this topic. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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12th COMPAMED Spring Convention

02. Mai. 2018

Implants in Medical Technology (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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12. COMPAMED Frühjahrsforum

02. Mai. 2018

Implantate in der Medizintechnik (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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