Immunological scarring from celiac disease

Immune cells in the bowel of people who suffer with celiac disease are permanently replaced by a new subset of cells that promote inflammation, suggests a new study.

Quelle: Sciencedaily

Cell study sheds light on damage caused by aging

Some of the damaging cell effects linked to aging could be prevented by manipulating tiny parts of cells, a study shows.

Quelle: Sciencedaily

Platinum nanoparticles for selective treatment of liver cancer cells

Researchers recently demonstrated that platinum nanoparticles can be used to kill liver cancer cells with greater selectivity than existing cancer drugs.

Quelle: Sciencedaily

Genetic variations in a fourth gene linked to elevated leukemia risk in Hispanic children

Progress reported on understanding why Hispanic children are more likely to develop acute lymphoblastic leukemia and to die of the disease.

Quelle: Sciencedaily

Only ‚modest‘ improvement in heart failure survival rates since 2000

Survival after a diagnosis of heart failure in the United Kingdom has shown only modest improvement in the 21st century and lags behind other serious conditions, such as cancer, finds a large study.

Quelle: Sciencedaily

Bioluminescent deep-sea creatures illuminate the effectiveness of new cancer therapies

A new tool can improve development and effectiveness of leading-edge cancer therapies derived from patients‘ immune systems.

Quelle: Sciencedaily

Revealing human antibody secrets

Using sophisticated gene sequencing and computing techniques, researchers have achieved a first-of-its-kind glimpse into how the body’s immune system gears up to fight off infection.

Quelle: Sciencedaily

Platelet ‚decoys‘ outsmart both clots and cancer

What do heart disease, stroke, sepsis, and cancer have in common, aside from being deadly diseases? They’re all linked to platelets, the cells in our blood that normally help our blood clot. New research has created ‚decoy‘ platelets that can both prevent blood clots and keep cancer from spreading.

Quelle: Sciencedaily

New therapy for aggressive blood cancer discovered

Acute myeloid leukemia (AML) is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells. Only twenty-five percent of all AML patients survive five years beyond the initial diagnosis. Therefore there is an urgent need to deepen the knowledge about this form of blood cancer and to develop new therapeutic approaches.

Quelle: Sciencedaily

Role of estrogen in controlling Type 2 diabetes

The results of a recent study provide insights into the mechanism by which estrogen can decrease insulin resistance and the production of glucose, reducing incidences of Type 2 diabetes mellitus.

Quelle: Sciencedaily

How breast tissue stiffening promotes breast cancer development

By examining how mammary cells respond in a stiffness-changing hydrogel, researchers discovered that several pathways work together to signal breast cells to turn cancerous. The work could inspire new approaches to treating patients and inhibiting tumor growth.

Quelle: Sciencedaily

Large study fails to link phthalates and increased breast cancer risk

In the largest study to date on phthalates and postmenopausal breast cancer, a cancer epidemiology researcher found no association between breast cancer risk and exposure to the plasticizing and solvent chemicals used in such common products as shampoo, makeup, vinyl flooring, toys, medical devices and car interiors.

Quelle: Sciencedaily

More efficient system to reprogram stem cells

Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails.

Quelle: Sciencedaily

How Viagra puts a brake on a master growth regulator to treat heart disease

When normal cells grow, divide or do any job in the body, they do so in response to a whole slew of internal sensors that measure nutrients and energy supply, and environmental cues that inform what happens outside the cell.

Quelle: Sciencedaily

Study finds upsurge in ‚active surveillance‘ for low-risk prostate cancer

Many men with low-risk prostate cancer who most likely previously would have undergone immediate surgery or radiation are now adopting a more conservative ‚active surveillance‘ strategy, according to a new study.

Quelle: Sciencedaily

Cancer comparison across species highlights new drug targets

Cancer genes in mucosal melanoma, a rare and poorly understood subtype of melanoma, have been compared in humans, dogs and horses for the first time. Researchers sequenced the genomes of the same cancer across different species to pinpoint key cancer genes. The results give insights into how cancer evolves across the tree of life and could guide the development of new therapies.

Quelle: Sciencedaily

Masterswitch discovered in body’s immune system

Scientists have discovered a critical part of the body’s immune system with potentially major implications for the treatment of some of the most devastating diseases affecting humans. The study could translate into treatments for autoimmune diseases including Cancer, Diabetes, Multiple Sclerosis and Crohn’s Disease within a few years.

Quelle: Sciencedaily

Interaction between immune factors triggers cancer-promoting chronic inflammation

A research team has identified interaction between two elements of the immune system as critical for the transformation of a protective immune response into chronic, cancer-promoting inflammation.

Quelle: Sciencedaily

Changes in lung cells seen almost immediately after contact with low-molecular weight PAHs

A new study shows cancer-promoting changes in lung cells as soon as 30 minutes after exposure to low-molecular weight PAHs, adding further evidence that regulators may be underestimating the risk of these compounds.

Quelle: Sciencedaily

PET imaging agent may allow early measurement of efficacy of breast cancer therapy

Physicians may soon have a new way to measure the efficacy of hormone therapy for breast cancer patients.

Quelle: Sciencedaily

Researchers 3D bio-print a model that could lead to improved anticancer drugs and treatments

Researchers have developed a way to study cancer cells which could lead to new and improved treatment. They have developed a new way to study these cells in a 3D in vitro model (i.e., in a culture dish rather than in a human or animal).

Quelle: Sciencedaily

Shorter course of radiation therapy effective in treating men with prostate cancer: study

A long-term study finds that those with low- or intermediate-risk disease can safely cut treatment to four to five days.

Quelle: Sciencedaily

More than half a million breast cancer deaths averted in the US over three decades

Latest US estimates indicate that since 1989, hundreds of thousands of women’s lives have been saved by mammography and improvements in breast cancer treatment. The findings point to progress made in early detection and management of breast cancer.

Quelle: Sciencedaily

Vitamin D and immune cells stimulate bone marrow disease

The bone marrow disease myelofibrosis is stimulated by excessive signaling from vitamin D and immune cells known as macrophages, reveals a research team. These findings could help to develop alternative treatments that do not target problem genes.

Quelle: Sciencedaily

Researchers develop human cell-based model to study small cell lung cancer

Researchers have used human embryonic stem cells to create a new model system that allows them to study the initiation and progression of small cell lung cancer (SCLC). The study reveals the distinct roles played by two critical tumor suppressor genes that are commonly mutated in these highly lethal cancers.

Quelle: Sciencedaily