CT45 – A key to long-term survival in ovarian cancer

The diagnosis of ovarian cancer is still comparable to a death sentence. Only one in six patients survives more than 10 years after diagnosis. In a new study, an international research team from Germany, the USA, and Denmark, identified a molecular mechanism that is linked to patient long-term survival for those roughly 20% of the patients. By proteomic analysis, the protein CT45 was identified as a novel prognostic cancer cell marker. The authors further showed that the protein itself increases cancer cell death after platinum chemotherapy and activates the patient’s immune system. This work will be published in the renowned scientific journal Cell. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)