Natural killer cells exhibit increased antitumor activity through CDK8 deletion

The human immune system uses natural killer (NK) cells as a weapon against cancer and virus-infected cells. A higher activity of the NK cells corresponds directly to a higher effectiveness in fighting tumors. Researchers at Vetmeduni Vienna, in a study published in Cancer Immunology Research, have now shown that it is possible to enhance NK cell activity even further by deleting the CDK8 gene. Until now, CDK8 is known to have an important role in the formation of tumors, where its activity is often amplified. Inhibiting CDK8 activity is the object of several current studies. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)