Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Targeting breast cancer through precision medicine

Researchers have discovered a mechanism that may make cancer cells more susceptible to treatment. The research team found that the protein RYBP prevents DNA repair in cancer cells, including breast cancer. (Mehr in: Cancer News — ScienceDaily)

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Cancer news

New clues to improving chemotherapies

21. Jun. 2018

The work has important implications for understanding how human cancer cells develop resistance to natural product-based chemotherapies. (Mehr in: Cancer News — ScienceDaily)

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Higher body fat linked to lower breast cancer risk in younger women

21. Jun. 2018

An analysis has linked higher body mass index, or BMI, to lower breast cancer risk for younger women, even for women within a normal weight range. (Mehr in: Cancer News — ScienceDaily)

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DNA enzyme shuffles cell membranes a thousand times faster than its natural counterpart

21. Jun. 2018

A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. This is the first such synthetic enzyme to outperform its natural counterpart — and it does so by three orders of magnitude. (Mehr in: Cancer News — ScienceDaily)

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New target to stop cancer growth uncovered

21. Jun. 2018

Researchers have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes — tiny, membrane-bound packages containing proteins and RNAs that stimulate tumor progression. The study could lead to new therapies that stop tumor growth and metastasis by halting exosome production. (Mehr in: Cancer News — ScienceDaily)

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Human immune ‚trigger‘ map paves way for better treatments

21. Jun. 2018

A discovery about how human cells are ‚triggered‘ to undergo an inflammatory type of cell death could have implications for treating cancer, stroke and tissue injury, and immune disorders. A research team has identified the molecular trigger in human cells that drives necroptosis, and implicated defects in this molecular trigger as potentially playing a role in cancer development. (Mehr in: Cancer News — ScienceDaily)

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Opening up a drug delivery route: Discovery of a new vehicle peptide

21. Jun. 2018

The bottleneck of cationic antimicrobial peptides as anticancer therapeutics is their limited ability to penetrate cell membranes. Researchers discovered a cyclic decapeptide (termed peptide 1) that serves as a promising lead compound as a new intracellular delivery vehicle for therapeutically effective peptides. When conjugated with another membrane impermeable proapoptotic domain (PAD) peptide, the compound was found to have significantly inhibitory activity in cancer cell lines. (Mehr in: Cancer News — ScienceDaily)

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Transport of lipid-conjugated floxuridine by natural serum albumin for delivery to cancer cells

21. Jun. 2018

How can elimination of therapeutics from the bloodstream or their early enzymatic degradation be avoided in systemic delivery? Scientists have new developed a method to bind an established cancer therapeutic, floxuridine, with natural serum albumin for its transport and delivery to target cancer cells. (Mehr in: Cancer News — ScienceDaily)

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Novel therapy makes oxidative stress deadly to cancer

21. Jun. 2018

Oxidative stress can help tumors thrive, but one way novel cancer treatments work is by pushing levels to the point where it instead helps them die, scientists report. (Mehr in: Cancer News — ScienceDaily)

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New drug halves hearing loss in children following cancer treatment

20. Jun. 2018

Giving the drug sodium thiosulphate after chemotherapy reduces hearing loss in children treated for liver cancer, according to new findings. (Mehr in: Cancer News — ScienceDaily)

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Competition for space: Oncogenic mutant cells vs normal cells

20. Jun. 2018

Researchers discovered how oncogenic mutant cells selectively expand into surrounding normal tissues and occupy them based on prediction by computer simulation and experimental verification. (Mehr in: Cancer News — ScienceDaily)

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How pancreatic tumors lead to weight loss

20. Jun. 2018

A study offers insight into the weight loss seen in pancreatic cancer patients, and suggests that weight loss may not necessarily affect patients‘ survival. (Mehr in: Cancer News — ScienceDaily)

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Towards personalised medicine: One type of data is not enough

20. Jun. 2018

To understand the biology of diseased organs researchers can use different types of molecular data. One of the biggest computational challenges at the moment is integrating these multiple data types. A new computational method jointly analyses different types of molecular data and disentangles the sources of disease variability to guide personalised treatment. (Mehr in: Cancer News — ScienceDaily)

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New therapeutic opportunity for the treatment of resistant malignant melanoma

20. Jun. 2018

Researchers have revealed that malignant melanoma can reprogram their protein synthesis machinery and become addicted to a new family of enzymes that modify transfer RNAs during acquired resistance. The inhibition of these molecules synergies with targeted therapies to produce a strong anti-tumoral effect. These new findings will be key in the development of improved diagnostic tools and melanoma treatment. (Mehr in: Cancer News — ScienceDaily)

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Rare in-vivo study shows weak brain nodes have strong influence on memory network

20. Jun. 2018

The majority of existing simulation studies show that the parts of the brain with high connectivity, the so-called ‚hubs‘, are most important when it comes to several different cognitive tasks. But the results of a rare in-vivo study demonstrates that the nucleus accumbens (NAc) — a part of the brain with weak connections — plays an unexpectedly influential role in enhancing the memory network. (Mehr in: Cancer News — ScienceDaily)

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New tissue-imaging technology could enable real-time diagnostics, map cancer progression

20. Jun. 2018

A new microscope system can image living tissue in real time and in molecular detail, without any chemicals or dyes. It enables researchers to study concurrent processes within cells and tissue, and could give cancer researchers a new tool for tracking tumor progression and physicians new technology for tissue pathology and diagnostics. (Mehr in: Cancer News — ScienceDaily)

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Putting the brakes on metastatic cancer

20. Jun. 2018

A groundbreaking discovery has identified previously unknown therapeutic targets that could be key to preventing the spread of cancer. Researchers found that by inhibiting several newly identified gene targets they could block more than 99.5 per cent of cancer metastasis in living cells. (Mehr in: Cancer News — ScienceDaily)

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Long-term estrogen therapy changes microbial activity in the gut

19. Jun. 2018

Long-term therapy with estrogen and bazedoxifene alters the microbial composition and activity in the gut, affecting how estrogen is metabolized, a new study in mice found. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

10. Stuttgarter Lasertage

01. Jun. 2018

Highlights und Innovationen aus der industriellen Anwendung der Lasertechnik stehen im Mittelpunkt der 10. Stuttgarter Lasertage (SLT 2018), die am 5. und 6. Juni 2018 parallel zur Fachmesse LASYS im Internationalen Congress Center Stuttgart (ICS) stattfinden. Veranstalter sind das Institut für Strahlwerkzeuge (IFSW) der Universität Stuttgart und die Messe Stuttgart. Erwartet werden rund 350 Besucher. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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15. HepNet Symposium der Deutschen Leberstiftung

01. Jun. 2018

Akkreditiert: mit 10 CME-Punkten von der Ärztekammer Niedersachsen mit 5 iCME-Punkten von der Akademie für Infektionsmedizin

Wissenschaftliche Leitung: Prof. Dr. med. Michael P. Manns, Hannover Prof. Dr. med. Stefan Zeuzem, Frankfurt Prof. Dr. med. Claus Niederau, Oberhausen Prof. Dr. med. Ulrike Protzer, München Prof. Dr. med. Peter Schirmacher, Heidelberg

Veranstalter: Deutsche Leberstiftung

Ort: Medizinische Hochschule Hannover, Gebäude J02, Hörsaal D (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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38. Jahrestagung der Deutschen Gesellschaft für Senologie e.V.

01. Jun. 2018

Unter dem diesjährigen Kongressmotto „4-Ländertagung: Senologie gleich Evolution“ organisiert die Deutschen Gesellschaft für Senologie e.V. (DGS) ihre Jahrestagung erstmalig gemeinsam mit Partnergesellschaften aus Österreich, der Schweiz und Frankreich. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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2nd International Symposium for Molecular Medicine

01. Jun. 2018

Das internationale Symposium für Molekulare Medizin findet zum zweiten Mal in Düsseldorf statt und bringt Wissenschaft und Klinische Praxis im Bereich Orthopädie, Dermatolgie und Alterungsmedizin zusammen. Durch das hochkarätig besetzte Programm führen Prof. Dr. Chris Evans, Genforscher an der Mayo-Klinik Rochester, und Prof. Dr. Martina Kerscher, Inhaberin des Lehrstuhls für Kosmetikwissenschaft an der Universität Hamburg. Workshops ergänzen das Programm. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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2. DGA-Interventionekongress

01. Jun. 2018

Nutzen Sie die Gelegenheit, sich über die Weiterentwicklung von minimalinvasiven Techniken in der Behandlung von Gefäßerkrankungen auf den neuesten Stand zu bringen. Wir möchten außerdem mit Ihnen diskutieren, wie unsere Patienten von neuen Herangehensweisen profitieren können. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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24. Jahrestagung der Deutschen Gesellschaft für Radioonkologie e. V.

01. Jun. 2018

Das wissenschaftliche Programm ist online einsehbar unter http://degro-jahrestagung.de/programm/wissenschaftliches-programm (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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1. World Café 2018 des DGBMT Fachausschusses Usability

01. Jun. 2018

Der DGBMT Fachausschuss Usability befasst sich mit allen Aspekten der Gebrauchstauglichkeit und User Experience in Zusammenhang mit Medizintechnik. Regelmäßig entscheidet der Fachausschuss dabei über neue Schwerpunkte für die kommenden Jahre. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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