About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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Deep-sea animals "eat" oil: One man’s meat is another man’s poison

Scientists from Germany and the USA have discovered deep-sea animals living in symbiosis with bacteria that use oil as an energy source. At asphalt volcanoes in the Gulf of Mexico that spew oil, gas and tar, mussels and sponges live in symbiosis with bacteria that use short-chained alkanes in the oil as an energy source. The researchers furthermore discovered that bacteria closely related to the symbionts, which bloomed during the Deepwater Horizon oil spill, are also able to thrive on short-chain alkanes. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

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Cancer news

COX-2 inhibitors may reverse IDO1-mediated immunosuppression in some cancers

21. Jul. 2017

In preclinical studies, tumors that consitutively expressed the protein indoleamine 2,3-dioxygenase (IDO1) responded to the cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex) and had improved infiltration of certain subsets of T cells, making them more likely to respond to anti-PD1 therapies, report researcher. (Mehr in: Cancer News — ScienceDaily)

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Shooting the Achilles heel of nervous system cancers

20. Jul. 2017

Scientists have devised a strategy to target cancer cells while sparing normal cells by capitalizing on vulnerabilities that are exposed only in tumor cells. These vulnerabilities are known as the ‚Achilles heel‘ of cancer cells. Although much is known about the mutations that cause a cell to become malignant, little is known about these vulnerabilities. (Mehr in: Cancer News — ScienceDaily)

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Genetic predisposition to breast cancer due to non-BRCA mutations in Ashkenazi Jewish women

20. Jul. 2017

Genetic mutations in BRCA1 and BRCA2 increase the risk of breast and ovarian cancer in Ashkenazi Jewish women. A new article pexamines the likelihood of carrying another cancer-predisposing mutation in BRCA1, BRCA2 or another breast cancer gene among women of Ashkenazi Jewish ancestry with breast cancer who do not carry one of the founder mutations. (Mehr in: Cancer News — ScienceDaily)

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Concurrent chemotherapy, proton therapy improves survival in patients with advanced lung cancer

20. Jul. 2017

For patients with advanced, inoperable stage 3 lung cancer, concurrent chemotherapy and the specialized radiation treatment, proton therapy, offers improved survival compared to historical data for standard of care, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Young adult cancer survivors struggle to get back to normal

20. Jul. 2017

Cancer survivors often talk about wanting to get back to normal, but a new study indicates many young adults who survived the disease struggle with attaining this goal two years after their initial diagnosis. (Mehr in: Cancer News — ScienceDaily)

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Molecular changes with age in normal breast tissue are linked to cancer-related changes

20. Jul. 2017

New research provides insight into how changes that occur with age may predispose breast tissue cells to becoming cancerous. Specifically, the study demonstrates that regions in the genome where DNA methylation changes occur with age are particularly sensitive to disruption in cancer. This new data provides insight into how certain molecular changes with age in normal breast tissue itself may contribute to breast cancer risk. (Mehr in: Cancer News — ScienceDaily)

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Using a pig model to study chronic diseases may help minimize drug failure rate

20. Jul. 2017

Scientists may be able to minimize the failure rate of drugs for diseases linked to high-calorie diets, such as colon cancer and type 2 diabetes, if they test treatments using a pig model, according to an international team of researchers. (Mehr in: Cancer News — ScienceDaily)

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Parents have critical role in preventing teen drinking

20. Jul. 2017

Fewer Australian teenagers are drinking alcohol but more needs to be done to curb the drinking habits of Aussie students, based on the findings of the latest study. (Mehr in: Cancer News — ScienceDaily)

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Immune-cell numbers predict response to combination immunotherapy in melanoma

20. Jul. 2017

Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study. (Mehr in: Cancer News — ScienceDaily)

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Macrophages made to engulf cancer cells in solid tumors

19. Jul. 2017

Human macrophages have been engineered to ignore the ‚don’t eat me‘ signal both healthy and cancerous cells exhibit. Combined with cancer-specific targeting antibodies, these engineered macrophages invaded and engulfed human tumor cells in a mouse model. (Mehr in: Cancer News — ScienceDaily)

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Combining CAR T cells with existing immunotherapies may overcome resistance in glioblastomas

19. Jul. 2017

Genetically modified “hunter” T cells successfully migrated to and penetrated a deadly type of brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive tumor microenvironment and faced a complex mutational landscape that will need to be overcome to better treat this aggressive cancer, researchers report. (Mehr in: Cancer News — ScienceDaily)

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Definitive genomic study reveals alterations driving most medulloblastoma brain tumors

19. Jul. 2017

An international consortium completed a landmark study of most common pediatric brain tumor, revealing new cancer genes, laying the foundation to expand precision medicine. (Mehr in: Cancer News — ScienceDaily)

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Social interaction affects cancer patients‘ response to treatment

19. Jul. 2017

How well cancer patients fared after chemotherapy was affected by their social interaction with other patients during treatment, according to a new study. Cancer patients were a little more likely to survive for five years or more after chemotherapy if they interacted during chemotherapy with other patients who also survived for five years or more. (Mehr in: Cancer News — ScienceDaily)

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New way found to boost immunity in fight cancer and infections

19. Jul. 2017

A key new mechanism has been identified that regulates the ability of T-cells of the immune system to react against foreign antigens and cancer. (Mehr in: Cancer News — ScienceDaily)

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How CD44s gives brain cancer a survival advantage

19. Jul. 2017

In the case of glioblastoma multiforme, the deadliest type of brain cancer, researchers have discovered that the molecule CD44s seems to give cancer cells a survival advantage. In the lab, eliminating this advantage by reducing the amount of CD44s resulted in cancer cells being more sensitive to the deadly effects of the drug erlotinib. (Mehr in: Cancer News — ScienceDaily)

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Why do BRCA1 mutations cause predominantly breast and ovarian cancer?

19. Jul. 2017

Researchers report a new, previously unrecognized function of the BRCA1 gene that explains why BRCA1 gene mutation carriers are at increased risk of breast and ovarian cancer. (Mehr in: Cancer News — ScienceDaily)

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Large-scale study of adaptation in yeast could help explain the evolution of cancer

18. Jul. 2017

A genome sequencing approach has been used to reveal the ‚drivers‘ of adaptation in laboratory-evolved yeast. This work uncovers roles of genetic hitchhiking and interaction in determining which mutations succeed or fail in rapidly-evolving microbial population and may hold clues to the dynamics of cancer evolution. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

15th EUROPEAN CONFERENCE ON ORGANIZED FILMS

08. Jul. 2017

The 15th European Conference on Organized Films (ECOF 15) adds to a successful series of conferences addressing latest findings and advances in the field of thin and ultrathin organic films as well as nanoscience and -technologies. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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14th Dortmund MST Conference – Individualized Healthcare Solutions

05. Jul. 2017

Embracing „Individualized Healthcare Solutions“, the 14th Dortmund MST Conference on July 5, 2017 will present microsystems, production processes and digital technologies for use in medical technology and healthcare. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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14. Dortmunder MST-Konferenz – Individualisierte Gesundheitslösungen

05. Jul. 2017

Unter dem Motto „Individualisierte Gesundheitslösungen“ präsentiert die 14. Dortmunder MST-Konferenz am 5. Juli 2017 Mikrosysteme, mikrotechnische Fertigungsverfahren und digitale Technologien für den Einsatz in der Medizintechnik und Gesundheitsversorgung. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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2. Praxis-Workshop "Notfallmedizin für Ingenieure"

02. Jun. 2017

In der Notfallmedizin müssen Ärzte oftmals unter schwierigsten Umgebungsbedingungen und in kurzer Zeit valide Diagnosen stellen. Dafür ist eine verlässliche und gut zu bedienende Medizintechnik unerlässlich. Aber auch in diesem interdisziplinären Teilgebiet der Medizin werden sich technische Innovationen nur durchsetzen, wenn diese perfekt auf die Bedürfnisse der Betreiber und Anwender abgestimmt sind. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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17th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery

02. Jun. 2017

Call for Abstracts (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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14. HepNet Symposium

02. Jun. 2017

Akkreditiert: mit 10 CME-Punkten von der Ärztekammer Niedersachsen mit 13 iCME-Punkten von der Akademie für Infektionsmedizin

Wissenschaftliche Leitung: Prof. Dr. med. Michael P. Manns, Hannover Prof. Dr. med. Stefan Zeuzem, Frankfurt Prof. Dr. med. Claus Niederau, Oberhausen Prof. Dr. med. Ulrike Protzer, München Prof. Dr. med. Peter Schirmacher, Heidelberg (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Art / Nature:Contemporary Art in Natural History Museums and Collections

02. Jun. 2017

A pilot project in cooperation with the German Federal Cultural Foundation.

The conference outlines recent and ongoing art projects and art programmes in natural history museums and in the natural history collections of multidisciplinary museums. In doing so, it aims to reflect upon and discuss the expectations, potentials, possible limitations and values of these kinds of interactions and interventions from the perspectives of curators, artists and researchers. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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