A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming Wallace hypothesized mitochondrial dysfunction as a central role in a wide range of age-related disorders and various forms of cancer. Steadily rising increases in mitochondrial DNA mutations cause abr

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Quantum entanglement between the electron clouds of nucleic acids in DNA

Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy

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A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination - stil

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Mitochondria and the evolutionary roots of cancer

Cancer is a group of almost 200 diseases that involve variety of changes in cell structure, morphology, and physiology. Cancer phenotype is underlying several alterations in cellular dynamics with three most critical features, which includes self-sufficiency in growth signals and insensitivity to in

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among t

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Wholeness and implicate order: “Deep” quantum chemistry and cell consciousness: quantum chemistry controls genes and biochemistry to give cells and higher organism’s consciousness and complex behavior

Bohm used the term ‘holomovement’ which is an unbroken and undivided totality and carries an implicate order which is he totality of an order including both the manifested and non-manifested aspects of the order. Non-local quantum phenomena reside in a subtler level than quantum level that is th

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Quantum Tunnelling to the Origin and Evolution of Life

Quantum tunnelling is a phenomenon which becomes relevant at the nanoscale and below. It is a paradox from the classical point of view as it enables elementary particles and atoms to permeate an energetic barrier without the need for sufficient energy to overcome it. Tunnelling is being of vital imp

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Quantum Teleportation and Von Neumann Entropy

From the aspect of the quantum information theories, various quantum entropies are possibly computed at each stage, which ensures the emergence of the entangled states in the intermediate step. If a single qubit quantum teleportation is near the computational basis, the quantum measurement is domina

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About metabolism of a carcinoma cell

Most cancer cells utilize aerobic glycolysis irrespective of their tissue of origin. The alteration from oxidative phosphorylation to glycolysis – called the Warburg effect – is an universal phenomen and has now become a diagnostic tool for cancer detection. Warburg O, Posener K, Negelein E.

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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline

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New name as of 2017: ZMT now called Leibniz Centre for Tropical Marine Research

The Leibniz Center for Tropical Marine Ecology – ZMT for short – is now called the Leibniz Centre for Tropical Marine Research. (Old German name: Leibniz-Zentrum für Marine Tropenökologie; new German name: Leibniz-Zentrum für Marine Tropenforschung.) The name change entered into force on January 1, 2017. The name change takes into account the increasingly interdisciplinary scope of the ZMT, which includes both the natural sciences and the social sciences. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)

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Cancer news

Cleverly designed tuberculosis vaccine shows promise in mice

13. Jan. 2017

A clever new tuberculosis vaccine has shown promise in trials in mice. If it succeeds, it will be the first new TB vaccine in a century. With the rise of multidrug resistant tuberculosis, the difficulty of curing the disease, and the large annual death toll, a successful vaccine could be a huge benefit to public health — especially in low- and middle income countries. (Mehr in: Cancer News — ScienceDaily)

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MIA transport protein no longer missing in action

13. Jan. 2017

Scientists have made a breakthrough in understanding how valuable anti-cancer compounds are produced in the Madagascar Periwinkle (Catharanthus roseus). (Mehr in: Cancer News — ScienceDaily)

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Reducing the radioresistance of cancer

13. Jan. 2017

Some cancer cells are protected from radiation therapy through an interaction of interleukin-6 with the Nrf2-antioxidant pathway, researchers have found. The discovery is believed to improve methods of increasing cancer’s radiosensitivity. (Mehr in: Cancer News — ScienceDaily)

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Master regulator of cellular aging discovered

12. Jan. 2017

Scientists have discovered a protein that fine-tunes the cellular clock involved in aging. (Mehr in: Cancer News — ScienceDaily)

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‚Mysterious‘ non-protein-coding RNAs play important roles in gene expression

12. Jan. 2017

Enhancers boost the rate of gene expression from nearby protein-coding genes so a cell can pump out more of a needed protein molecule. A mysterious subset of non-coding RNAs — enhancer RNAs (eRNAs) are transcribed from enhancer sequences. Shedding new light on these elusive eRNAs, researchers showed that CBP, an enzyme that activates transcription from enhancers, binds directly to eRNAs to control patterns of gene expression by acetylation. (Mehr in: Cancer News — ScienceDaily)

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How well do we understand the relation between incorrect chromosome number, cancer?

12. Jan. 2017

Researchers report surprising results of experiments intended to explore the consequences of having too many or too few chromosomes, a phenomenon that biologists call aneuploidy. They were surprised to find that having one extra chromosome actually supresses cancer, contrary to long-held belief. (Mehr in: Cancer News — ScienceDaily)

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Advanced metastatic midgut neuroendocrine tumors: New drug in development shows improved progression-free survival for patients

12. Jan. 2017

A new therapy in development for the treatment of midgut neuroendocrine tumors, a rare type of cancer that occurs in the small intestine and colon, shows improved progression-free survival and response rates for patients with advanced disease. (Mehr in: Cancer News — ScienceDaily)

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Researchers develop novel treatment to prevent graft-versus-host-disease

12. Jan. 2017

Graft-versus-host-disease (GVHD) is the leading cause of non-relapse associated death in patients who receive stem cell transplants. In a new study, researchers show that a novel treatment can effectively inhibit the development of GVHD in mice and maintain the infection- and tumor-fighting capabilities of the immune system. (Mehr in: Cancer News — ScienceDaily)

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Cost, technology issues are barriers to real-time cancer patient symptom reporting

12. Jan. 2017

In a perspective article, a researcher addresses the need for – and the barriers preventing – electronic reporting of patients’ symptoms between visits. (Mehr in: Cancer News — ScienceDaily)

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New genes identified that regulate the spread of cancers

11. Jan. 2017

Researchers have discovered a new biological target for drugs to reduce the spread of tumours in cancer patients. The study with genetically modified mice found 23 genes that are involved in regulating the spread of cancers. The researchers showed that targeting one of these genes — Spns2 — led to a three-quarters reduction in tumor spread. (Mehr in: Cancer News — ScienceDaily)

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Walking the tightrope: The balance between helping patients now without risking the future

11. Jan. 2017

Antibiotic use represents a special challenge, in which too much of a good thing can be dangerous to public health as a whole. The fight against a common, costly, hospital-acquired infection known as Clostridium difficile, or C. diff offers an illuminating case study in the area of so-called antibiotic stewardship. (Mehr in: Cancer News — ScienceDaily)

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For men with prostate cancer, emotional distress may lead to more aggressive treatment

11. Jan. 2017

The anxiety many men experience after being diagnosed with prostate cancer may lead them to choose potentially unnecessary treatment options, researchers report. (Mehr in: Cancer News — ScienceDaily)

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Bronchial carcinoma: Added benefit of crizotinib not proven

11. Jan. 2017

The dossier contains no data or no suitable data on ROS1-positive, advanced non-small cell lung cancer. Results on ALK-positive tumors are not applicable. (Mehr in: Cancer News — ScienceDaily)

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Tumor-seeking salmonella treats brain tumors

11. Jan. 2017

Genetic tweaks to salmonella turn the bacteria into cancer-seeking missiles that produce self-destruct orders deep within tumors. Tests in rat models with extreme cases of the disease showed a remarkable 20 percent survival rate over 100 days — roughly equivalent to 10 human years — with the tumors going into complete remission. (Mehr in: Cancer News — ScienceDaily)

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A novel cancer immunotherapy shows early promise in preclinical studies

11. Jan. 2017

Scientists report that GARP, a TGF-beta cell surface receptor, could be a novel diagnostic marker for breast, colon, and lung cancer. An antibody-based therapy targeting GARP prevented metastasis to the lung in a mouse model of breast cancer. Targeting GARP with an antibody could represent a novel addition to established immunotherapies that ‚wake up‘ the immune system so that it can fight cancer. (Mehr in: Cancer News — ScienceDaily)

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Surprise advance in the treatment of adult cancers

11. Jan. 2017

An epigenetic modification that might be the cause of 15% of adult cancers of the throat linked to alcohol and tobacco use was identified. This discovery was unexpected since it seemed highly improbable that this kind of alterations of the epigenome found in children could also target an epithelial tumor like throat cancer that occurs only in adults. (Mehr in: Cancer News — ScienceDaily)

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New material in the fight against hospital-acquired infections

11. Jan. 2017

Researchers have developed a new light-activated antimicrobial material for use in the fight against the most common hospital infections. (Mehr in: Cancer News — ScienceDaily)

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Veranstaltungen

1st DZHK Conference on Translational Medicine

01. Jan. 2017

Wie kommt die Forschung zum Patienten? Darum geht es in der ersten DZHK-Konferenz im Januar 2017 in Berlin mit internationalen Experten aus verschiedenen medizinischen Fachrichtungen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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5. Nationales Biobanken-Symposium 2016

01. Dez. 2016

Leitthema: Biobanken als Bindeglied zwischen Versorgung und Forschung – Call for Papers bis 01.07.2016 (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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11. Kölner Abend der Sportwissenschaft mit Wolf-Dieter Poschmann

01. Dez. 2016

Die Deutsche Sporthochschule Köln und die Gesellschaft der Freunde und Förderer laden Sie herzlich zum 11. Kölner Abend der Sportwissenschaft am 8. Dezember 2016 (Hörsaal 1 der Deutschen Sporthochschule Köln, 19:00 Uhr) zu folgendem Thema ein:

Der Arbeitsplatz der Zukunft – Bewegtes Arbeiten statt riskantem Sitzen? (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Gründung der Medizinischen Fakultät der Universität

01. Dez. 2016

Zum Festakt anlässlich der Gründung der Medizinischen Fakultät der Universität Augsburg sind die Vertreterinnen und Vertreter der Medien herzlich eingeladen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Forum MikroskopieTrends ´16: Von der Probe zum digitalen Modell

01. Dez. 2016

Durch den immer tieferen Einblick in den mikroskopischen Aufbau von Proben müssen diese für die jeweiligen Mikroskopieverfahren entsprechend aufbereitet werden. Das Forum stellt verschiedene Ansätze und Methoden sowie Entwicklungen in der Mikroskopie vor. Beispiele sind die Optische Kohärenztomographie, die Manipulation von DNA, die STED- und Lichtblatt-Mikroskopie oder das Digital Imaging. Aber auch Fragestellungen aus der Mathematik und (Big)Data-Auswertungen werden beleuchtet. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Entrepreneurship und der Weg zur eigenen Firma für Physiker/innen

01. Dez. 2016

Der Workshop bringt Interessierten unternehmerisches Denken und Handeln näher, vermittelt Grundlagen der Unternehmensgründung sowie des strategischen Managements und der Unternehmensführung. Zudem bietet er die Möglichkeit, die eigenen Schlüsselqualifikationen und Softskills auszubauen. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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Aquatic Actinide Chemistry and Thermodynamics at Elevated Temperatures (ThermAc)

01. Dez. 2016

Repositories for highly active heat producing waste will feature elevated temperatures over a significant period after closure. If early canister failure occurs, radionuclides therefore may contact aquatic systems at higher temperatures. For such conditions, the chemical understanding and available thermodynamic database for actinides, long-lived fission products and relevant matrix elements in aquatic systems has to be improved. (Mehr in: Veranstaltungen – idw – Informationsdienst Wissenschaft)

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